Vascular Endothelial Growth Factor A (VEGFA)
Vascular endothelial growth factor A (VEGFA) is a key signaling protein that plays a crucial role in angiogenesis, the process of new blood vessel formation from pre-existing vessels.
Vascular endothelial growth factor A (VEGFA) is a key signaling protein that plays a crucial role in angiogenesis, the process of new blood vessel formation from pre-existing vessels. It is part of the VEGF family, which includes several other growth factors that regulate vascular development and permeability. VEGFA primarily acts by binding to its receptors, VEGFR-1 and VEGFR-2, which are expressed on endothelial cells. This interaction stimulates endothelial cell proliferation, migration, and survival, thereby promoting the formation of new blood vessels. Due to its significant role in angiogenesis, VEGFA is a critical target in various therapeutic strategies, particularly in cancer treatment, where tumor growth and metastasis are often dependent on angiogenesis.
Where the papers sit
18 papers from the last 6 months study Vascular Endothelial Growth Factor A (VEGFA) directly · updated from PubMed 11 Oct 2026
Study type 0 clinical trials · 3 observational · 2 human data · 12 preclinical · 1 unclassified
Themes no clear themes
Those 18 do not share a common subject.
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VEGFA is examined across angiogenesis, endothelial barrier function, vascular tumors, wound repair, retinal disease, cancer, and transplantation. Interventions include aflibercept, faricimab, nanoparticles, hydrogels, gene activation, and combination therapy, alongside biomarker and genetic studies. The recurring aim is to modulate VEGFA to improve vascular integrity or angiogenesis, or to suppress pathological neovascularization. Because the diseases and endpoints differ substantially, the cluster supports no single therapeutic direction.
Papers
The 18 papers from the last 6 months that study Vascular Endothelial Growth Factor A (VEGFA) directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
No clear themes (18)
- Genetically predicted triglyceride levels and endometriosis risk: Mendelian randomization with exploratory multi-omics analyses. PloS one · 13 Aug 2026 PMID 42594068
- β-cell-targeted RNA activation of vascular endothelial growth factor-A improves islet transplantation. Signal transduction and targeted therapy · 3 Aug 2026 PMID 42547502
- Mechanistic study on the treatment of androgenetic alopecia with Platycladus orientalis leaf extract via regulation of the VEGFA/Bcl2 pathway: An in silico and in vitro study. Medicine · 18 Jul 2026 PMID 42469978
- Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function. Investigative ophthalmology & visual science · 2 Jul 2026 PMID 42390173
- A hypoxia-responsive migrasome-related lncRNA signature predicts prognosis and suggests the MSC-AS1/ITGA5 axis as a potential therapeutic target in head and neck squamous cell carcinoma. Functional & integrative genomics · 1 Jul 2026 PMID 42380675
- Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors. Cell reports. Medicine · 25 Jun 2026 PMID 42349416
- Targeted delivery of IDR-1018 via biomimetic magnetic nanovesicles suppresses neurovascular cell death and promotes angiogenic repair after neonatal hypoxic-ischemic brain injury. Apoptosis : an international journal on programmed cell death · 2 Jun 2026 PMID 42228206
- A bioactive hydrogel integrating bFGF/VEGFA gene-loaded nanoparticles and platelet-rich plasma for accelerated full-thickness skin wound healing. PloS one · 26 May 2026 PMID 42189841
- HMGA1 Lactylation-Mediated Regulation of the SP1/VEGFA Axis in Pathological Angiogenesis Under Diabetic Retinopathy. Diabetes · 8 May 2026 PMID 42102382
- VEGFA-Targeted M3-F4 Ionizable Lipid Nanoparticles Improve Diabetic Retinopathy. Molecular pharmaceutics · 6 May 2026 PMID 42089665
- New Pathological Insights into Biomarkers for Multimodal Therapeutic Approach in Hepatic Neuroendocrine Tumors: A Detailed Case Report. In vivo (Athens, Greece) · 28 Apr 2026 PMID 42049452
- Obesity and Pro-Inflammatory Cytokines: Gene Expression Patterns Within Cervical Cancer Progression. In vivo (Athens, Greece) · 28 Apr 2026 PMID 42049436
- Therapeutic Efficacy of PB101 and Chemotherapy Combination in Preclinical Gastric Cancer Models. Anticancer research · 28 Apr 2026 PMID 42049328
- Concurrent P-Selectin Targeting Nanoparticle Orchestrates Tumor-Immune Dynamics for Advanced Immunochemotherapy. ACS nano · 28 Apr 2026 PMID 42047284
- Rapid Effects on Anatomical and Functional Outcomes following Upload with Faricimab in Treatment-Naïve nAMD: German Single-Center Study 45DRY. Ophthalmology and therapy · 25 Apr 2026 PMID 42033608
- Kaposiform vascular tumors with Kasabach-Merritt phenomenon: a case series of KHE and KLA from a tertiary care center in India. European journal of pediatrics · 25 Apr 2026 PMID 42033477
- Ivonescimab combined with chemotherapy for the treatment of metastatic cervical cancer: A case report and literature review. Human vaccines & immunotherapeutics · 21 Apr 2026 PMID 42012232
- Multi-Omics and Machine Learning-Uncovered FLT1-Mediated Epithelial-Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 18 Apr 2026 PMID 41999263
By study type
Observational studies and case reports (3)
- New Pathological Insights into Biomarkers for Multimodal Therapeutic Approach in Hepatic Neuroendocrine Tumors: A Detailed Case Report. In vivo (Athens, Greece) · 28 Apr 2026 PMID 42049452
- Kaposiform vascular tumors with Kasabach-Merritt phenomenon: a case series of KHE and KLA from a tertiary care center in India. European journal of pediatrics · 25 Apr 2026 PMID 42033477
- Ivonescimab combined with chemotherapy for the treatment of metastatic cervical cancer: A case report and literature review. Human vaccines & immunotherapeutics · 21 Apr 2026 PMID 42012232
Human data, design not indexed (2)
- Genetically predicted triglyceride levels and endometriosis risk: Mendelian randomization with exploratory multi-omics analyses. PloS one · 13 Aug 2026 PMID 42594068
- Obesity and Pro-Inflammatory Cytokines: Gene Expression Patterns Within Cervical Cancer Progression. In vivo (Athens, Greece) · 28 Apr 2026 PMID 42049436
Preclinical: animal, cell and lab studies (12)
- β-cell-targeted RNA activation of vascular endothelial growth factor-A improves islet transplantation. Signal transduction and targeted therapy · 3 Aug 2026 PMID 42547502
- Mechanistic study on the treatment of androgenetic alopecia with Platycladus orientalis leaf extract via regulation of the VEGFA/Bcl2 pathway: An in silico and in vitro study. Medicine · 18 Jul 2026 PMID 42469978
- Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function. Investigative ophthalmology & visual science · 2 Jul 2026 PMID 42390173
- A hypoxia-responsive migrasome-related lncRNA signature predicts prognosis and suggests the MSC-AS1/ITGA5 axis as a potential therapeutic target in head and neck squamous cell carcinoma. Functional & integrative genomics · 1 Jul 2026 PMID 42380675
- Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors. Cell reports. Medicine · 25 Jun 2026 PMID 42349416
- Targeted delivery of IDR-1018 via biomimetic magnetic nanovesicles suppresses neurovascular cell death and promotes angiogenic repair after neonatal hypoxic-ischemic brain injury. Apoptosis : an international journal on programmed cell death · 2 Jun 2026 PMID 42228206
- A bioactive hydrogel integrating bFGF/VEGFA gene-loaded nanoparticles and platelet-rich plasma for accelerated full-thickness skin wound healing. PloS one · 26 May 2026 PMID 42189841
- HMGA1 Lactylation-Mediated Regulation of the SP1/VEGFA Axis in Pathological Angiogenesis Under Diabetic Retinopathy. Diabetes · 8 May 2026 PMID 42102382
- VEGFA-Targeted M3-F4 Ionizable Lipid Nanoparticles Improve Diabetic Retinopathy. Molecular pharmaceutics · 6 May 2026 PMID 42089665
- Therapeutic Efficacy of PB101 and Chemotherapy Combination in Preclinical Gastric Cancer Models. Anticancer research · 28 Apr 2026 PMID 42049328
- Concurrent P-Selectin Targeting Nanoparticle Orchestrates Tumor-Immune Dynamics for Advanced Immunochemotherapy. ACS nano · 28 Apr 2026 PMID 42047284
- Multi-Omics and Machine Learning-Uncovered FLT1-Mediated Epithelial-Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 18 Apr 2026 PMID 41999263
Unclassified: not yet indexed with MeSH (1)
- Rapid Effects on Anatomical and Functional Outcomes following Upload with Faricimab in Treatment-Naïve nAMD: German Single-Center Study 45DRY. Ophthalmology and therapy · 25 Apr 2026 PMID 42033608
Written from 18 PubMed abstracts, each one listed by PMID above. Published: 2026-06-17. Last written: 2026-08-26 by GPT. Drafted by language models from published abstracts; not medical advice.