Phosphatidylinositol 3-kinase (PI3K)
phosphatidylinositol 3-kinase (PI3K) is a key regulatory enzyme involved in cellular signaling processes and a critical target in drug development for multiple disease indications.
phosphatidylinositol 3-kinase (Phosphatidylinositol 3-kinase (PI3K)) is a key regulatory enzyme involved in cellular signaling processes and a critical target in drug development for multiple disease indications. PI3K catalyzes the phosphorylation of phosphatidylinositol lipids in cell membranes, generating secondary messengers that activate downstream signaling cascades. The enzyme exists in multiple isoforms (notably PI3K-δ and PI3K-γ), each with distinct tissue distribution and functional roles in immune cells, vascular endothelial cells, and other cell types. As a central node in the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Protein kinase B (PKB)) signaling pathway, PI3K regulates fundamental cellular processes including proliferation, survival, differentiation, and metabolism. Due to its dysregulation in various cancers and inflammatory diseases, PI3K has emerged as a major pharmaceutical target, with multiple small-molecule inhibitors and combination therapeutic strategies currently under investigation.
Where the papers sit
27 papers from the last 6 months study Phosphatidylinositol 3-kinase (PI3K) directly · updated from PubMed 12 Oct 2026
Study type 1 clinical trial · 1 human data · 23 preclinical · 2 unclassified
Themes one subject
Those 27 are all about one subject.
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PI3K Signaling in Disease
PI3K/AKT signaling recurs across cancer, fibrosis, wound healing, metabolic disease and neurodegeneration. Studies connect it with NF-κB, mTOR, macrophage polarization, autophagy and stromal remodeling. The work ranges from phytochemicals and biomaterials to PI3K inhibitors such as BKM120 and PI3Kγ-directed delivery systems. No single therapeutic direction dominates; the common aim is to link PI3K pathway modulation with improved tissue repair, treatment sensitivity or disease prognosis.
Papers
The 27 papers from the last 6 months that study Phosphatidylinositol 3-kinase (PI3K) directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
PI3K Signaling in Disease (27)
- Proteomic regulation of anti-proliferative and anti-migratory activity by potent phytochemicals from Pistacia integerrima J.L. Steward Ex Brandis via PI3K, AKT1, and KRAS for Lung Cancer. Molecular biology reports · 12 Sept 2026 PMID 42730982
- Ginkgolide A alleviated liver fibrosis by modulating PI3K/AKT/NF-κB signaling to inhibit M1 macrophage polarization and macrophage-HSC crosstalk. International immunopharmacology · 27 Aug 2026 PMID 42659933
- Design, synthesis and biological evaluation of novel 1,3,5-triazine derivatives containing benzo[d]imidazole scaffold as PI3K inhibitors. Bioorganic chemistry · 18 Aug 2026 PMID 42612260
- Hierarchically Aligned HNTs-Based Composite Foam with Immunomodulatory Activity for Diabetic Wound Healing. ACS applied bio materials · 17 Aug 2026 PMID 42606047
- pH-Responsive liposomes co-delivering a membrane-active peptide and the PI3Kγ inhibitor to reconstruct the tumor microenvironment for enhanced antitumor immunotherapy. Biomaterials science · 17 Aug 2026 PMID 42605855
- UBC9 and PI3K Expression in Colorectal Cancer: Possible Prognostic Role. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 29 Jul 2026 PMID 42522541
- Targeting casein kinase 1α-mediated FADD phosphorylation restores sensitivity in select CDK4/6 inhibitor-resistant breast cancer models. The Journal of clinical investigation · 28 Jul 2026 PMID 42518285
- Extraction-driven structural modulation dictates the anti-diabetic potency of Notopterygium franchetii polysaccharides. Carbohydrate polymers · 23 Jul 2026 PMID 42493156
- ADSC-Exo-bFGF promotes skin wound healing and correlates with the PI3K/AKT signaling pathway activation. Journal of molecular histology · 16 Jul 2026 PMID 42461467
- Multi-omics analysis of arginine metabolism in ovarian cancer: A prognostic signature and GTF2F2-driven stromal remodeling. Translational oncology · 13 Jul 2026 PMID 42442222
- Chronic Lithium Exposure Reshapes PI3K-mTOR-linked Proteostatic Networks in the Hippocampus of an Alzheimer's Disease Mouse Model. Molecular neurobiology · 6 Jul 2026 PMID 42410183
- Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy. Journal of controlled release : official journal of the Controlled Release Society · 6 Jul 2026 PMID 42409241
- Benefits and challenges of adding BKM120 to a BI-3406 plus trametinib combination therapy. BMC cancer · 3 Jul 2026 PMID 42399819
- Xiaokeping combined with low-carbohydrate diet slows cognitive decline in diabetic rats through activating TGF-β1/Smad7 signaling. Biotechnic & histochemistry : official publication of the Biological Stain Commission · 22 Jun 2026 PMID 42324965
- Designing inhalable amorphous solid dispersions to mitigate crystallization risks in atropisomer development. International journal of pharmaceutics · 19 Jun 2026 PMID 42320735
- Vitamin D regulates lipid metabolism in granulosa cells via the FABP3-associated PI3K/Akt pathway in polycystic ovary syndrome. International immunopharmacology · 16 Jun 2026 PMID 42302377
- Dimethyl fumarate attenuates post-infarct myocardial injury and is associated with modulation of the NRG-1/ErbB2/Akt pathway and reduction of oxidative stress. European journal of pharmacology · 2 Jun 2026 PMID 42229738
- Ergothioneine exerts neuroprotection in experimental ischemic stroke via activation of PI3K/Akt/Nrf2 pathway. Neuroreport · 29 May 2026 PMID 42214028
- Nuciferine alleviates cerebral ischemia-reperfusion injury by inhibiting mPTP opening via activating the phosphatidylinositol 3-kinase/protein kinase B/glycogen synthase kinase 3 beta pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology · 22 May 2026 PMID 42172986
- Design, synthesis, and biological evaluation of 2-morpholino-4H-chromen-4-one derivatives as a potent dual PI3K/BRD4 inhibitors. European journal of medicinal chemistry · 21 May 2026 PMID 42166816
- PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition. Cancer research · 7 May 2026 PMID 42095550
- Zhiwang decoction inhibits the inflammatory response and macrophage polarization in rheumatoid arthritis by mediating the PI3K/AKT phosphorylation pathway through cellular communication network factor 1. Journal of ethnopharmacology · 4 May 2026 PMID 42081959
- Danshensu derivative mitigate cerebral ischemia-reperfusion injury via the PI3K-AKT-CREB signaling pathway. Journal of ethnopharmacology · 2 May 2026 PMID 42069160
- Elucidation of the mechanisms and therapeutic effects of Sini Decoction on anxiety induced by forced swimming stress in mice. Journal of ethnopharmacology · 27 Apr 2026 PMID 42044778
- Design, Synthesis, and Biological Evaluation of Novel Triazine-Based Dual Histone Deacetylase/phosphatidylinositol 3-kinase Inhibitors for Breast Cancer Therapy. ChemMedChem · 26 Apr 2026 PMID 42035271
- Duvelisib Induces Deep Responses in Peripheral T-Cell Lymphoma: Final Results of the Phase II PRIMO Trial of Duvelisib in Relapsed/Refractory Peripheral T-Cell Lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 22 Apr 2026 PMID 42018969
- Miao medicine Jinshanxiaoke granules alleviates MASLD via Ampk/Ppar-α and Pi3k/Akt-mediated restoration of hepatic lipid homeostasis. Journal of ethnopharmacology · 16 Apr 2026 PMID 41990925
By study type
Clinical trials (1)
- Duvelisib Induces Deep Responses in Peripheral T-Cell Lymphoma: Final Results of the Phase II PRIMO Trial of Duvelisib in Relapsed/Refractory Peripheral T-Cell Lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 22 Apr 2026 PMID 42018969
Human data, design not indexed (1)
- UBC9 and PI3K Expression in Colorectal Cancer: Possible Prognostic Role. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 29 Jul 2026 PMID 42522541
Preclinical: animal, cell and lab studies (23)
- Proteomic regulation of anti-proliferative and anti-migratory activity by potent phytochemicals from Pistacia integerrima J.L. Steward Ex Brandis via PI3K, AKT1, and KRAS for Lung Cancer. Molecular biology reports · 12 Sept 2026 PMID 42730982
- Design, synthesis and biological evaluation of novel 1,3,5-triazine derivatives containing benzo[d]imidazole scaffold as PI3K inhibitors. Bioorganic chemistry · 18 Aug 2026 PMID 42612260
- Hierarchically Aligned HNTs-Based Composite Foam with Immunomodulatory Activity for Diabetic Wound Healing. ACS applied bio materials · 17 Aug 2026 PMID 42606047
- pH-Responsive liposomes co-delivering a membrane-active peptide and the PI3Kγ inhibitor to reconstruct the tumor microenvironment for enhanced antitumor immunotherapy. Biomaterials science · 17 Aug 2026 PMID 42605855
- Targeting casein kinase 1α-mediated FADD phosphorylation restores sensitivity in select CDK4/6 inhibitor-resistant breast cancer models. The Journal of clinical investigation · 28 Jul 2026 PMID 42518285
- Extraction-driven structural modulation dictates the anti-diabetic potency of Notopterygium franchetii polysaccharides. Carbohydrate polymers · 23 Jul 2026 PMID 42493156
- ADSC-Exo-bFGF promotes skin wound healing and correlates with the PI3K/AKT signaling pathway activation. Journal of molecular histology · 16 Jul 2026 PMID 42461467
- Chronic Lithium Exposure Reshapes PI3K-mTOR-linked Proteostatic Networks in the Hippocampus of an Alzheimer's Disease Mouse Model. Molecular neurobiology · 6 Jul 2026 PMID 42410183
- Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy. Journal of controlled release : official journal of the Controlled Release Society · 6 Jul 2026 PMID 42409241
- Benefits and challenges of adding BKM120 to a BI-3406 plus trametinib combination therapy. BMC cancer · 3 Jul 2026 PMID 42399819
- Xiaokeping combined with low-carbohydrate diet slows cognitive decline in diabetic rats through activating TGF-β1/Smad7 signaling. Biotechnic & histochemistry : official publication of the Biological Stain Commission · 22 Jun 2026 PMID 42324965
- Designing inhalable amorphous solid dispersions to mitigate crystallization risks in atropisomer development. International journal of pharmaceutics · 19 Jun 2026 PMID 42320735
- Vitamin D regulates lipid metabolism in granulosa cells via the FABP3-associated PI3K/Akt pathway in polycystic ovary syndrome. International immunopharmacology · 16 Jun 2026 PMID 42302377
- Dimethyl fumarate attenuates post-infarct myocardial injury and is associated with modulation of the NRG-1/ErbB2/Akt pathway and reduction of oxidative stress. European journal of pharmacology · 2 Jun 2026 PMID 42229738
- Ergothioneine exerts neuroprotection in experimental ischemic stroke via activation of PI3K/Akt/Nrf2 pathway. Neuroreport · 29 May 2026 PMID 42214028
- Nuciferine alleviates cerebral ischemia-reperfusion injury by inhibiting mPTP opening via activating the phosphatidylinositol 3-kinase/protein kinase B/glycogen synthase kinase 3 beta pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology · 22 May 2026 PMID 42172986
- Design, synthesis, and biological evaluation of 2-morpholino-4H-chromen-4-one derivatives as a potent dual PI3K/BRD4 inhibitors. European journal of medicinal chemistry · 21 May 2026 PMID 42166816
- PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition. Cancer research · 7 May 2026 PMID 42095550
- Zhiwang decoction inhibits the inflammatory response and macrophage polarization in rheumatoid arthritis by mediating the PI3K/AKT phosphorylation pathway through cellular communication network factor 1. Journal of ethnopharmacology · 4 May 2026 PMID 42081959
- Danshensu derivative mitigate cerebral ischemia-reperfusion injury via the PI3K-AKT-CREB signaling pathway. Journal of ethnopharmacology · 2 May 2026 PMID 42069160
- Elucidation of the mechanisms and therapeutic effects of Sini Decoction on anxiety induced by forced swimming stress in mice. Journal of ethnopharmacology · 27 Apr 2026 PMID 42044778
- Design, Synthesis, and Biological Evaluation of Novel Triazine-Based Dual Histone Deacetylase/phosphatidylinositol 3-kinase Inhibitors for Breast Cancer Therapy. ChemMedChem · 26 Apr 2026 PMID 42035271
- Miao medicine Jinshanxiaoke granules alleviates MASLD via Ampk/Ppar-α and Pi3k/Akt-mediated restoration of hepatic lipid homeostasis. Journal of ethnopharmacology · 16 Apr 2026 PMID 41990925
Unclassified: not yet indexed with MeSH (2)
- Ginkgolide A alleviated liver fibrosis by modulating PI3K/AKT/NF-κB signaling to inhibit M1 macrophage polarization and macrophage-HSC crosstalk. International immunopharmacology · 27 Aug 2026 PMID 42659933
- Multi-omics analysis of arginine metabolism in ovarian cancer: A prognostic signature and GTF2F2-driven stromal remodeling. Translational oncology · 13 Jul 2026 PMID 42442222
Written from 27 PubMed abstracts, each one listed by PMID above. Published: 2026-07-11. Last written: 2026-08-26 by GPT. Drafted by language models from published abstracts; not medical advice.