Collagen

Where the papers sit

12 papers from the last 6 months study collagen directly · updated from PubMed 12 Oct 2026

• Collagen-Based Skin Repair

  Collagen-rich hydrogels and bioinks aim to rebuild skin and close difficult wounds while controlling the local microenvironment. Collagen/hyaluronic acid/chitosan supports hemostasis and infected-wound healing, while photocurable collagen enables printed diabetic-wound repair. Other approaches target dermal fibroblasts with trans-amplifying RNA or deliver collagen transdermally for matrix regeneration and aging-skin rejuvenation. Janus hydrogels extend the platform to sweat-glucose and motion sensing, so therapeutic repair and monitoring remain only partly integrated.

  6 papers · 50%

• Scaffolds for Tissue Regeneration

  Biomaterial scaffolds are being used to couple extracellular cues with cell- and exosome-based tissue repair. Injury-preconditioned hUCMSC exosomes support neuroprotection and neuroregeneration in 3D brain constructs, while macrophage exosomes reduce mesenchymal-stem-cell senescence. Fibroin, PCL/nHA/SA/COL and airway extracellular-matrix bioinks extend this strategy across neural, bone and airway repair. The shared direction is toward biomimetic printed constructs, although functional tissue maturation remains an open challenge.

  3 papers · 25%

• Collagen and Tumor Immunity

  Collagen is being treated as both a barrier to antitumor immunity and a measurable feature of tumor biology. ITGA2 blockade remodels the breast-cancer microenvironment and improves anti-PD-L1 activity, while ADAMTS1-driven collagenolysis reverses castration resistance and immunosuppression. Digital pathology links intratumoral collagen with pituitary neuroendocrine tumors, supporting its use as a context-dependent biomarker. The work is moving toward collagen-aware immunotherapy and stratification, but whether collagen depletion or specific integrin targeting benefits patients remains open.

  3 papers · 25%