Senescence
Senescence is a biological process in which cells enter a durable state of reduced or absent proliferation.
Senescence is a biological process in which cells enter a durable state of reduced or absent proliferation. It is studied at the cellular level as cellular senescence and at the organismal level in relation to ageing, tissue degeneration, and organ function. In the supplied literature, senescence is associated with DNA damage, reactive oxygen species, oxidative stress, altered metabolism, and signaling through regulators including p16, p21, TP53, ATM, AMPK, mTOR, and Wnt pathways.
Senescent cells may also be characterized by a Senescence-Associated Secretory Phenotype (SASP), which can connect cellular senescence with inflammation, fibrosis, neuroinflammation, and impaired tissue regeneration. Consequently, senescence is being investigated both as a process to prevent or reverse in damaged tissues and as a therapeutic target in cancer. Current approaches include senolytic or senescence-targeted nanotherapy, modulation of autophagy and mitochondrial function, manipulation of redox and inflammatory signaling, and use of senescence-related molecular signatures to predict responses to immunotherapy.
Where the papers sit
10 papers from the last 6 months study senescence directly · updated from PubMed 12 Oct 2026
Study type 0 clinical trials · 1 human data · 8 preclinical · 1 unclassified
Themes 3 themes · 1 paradigm shift
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Cellular Senescence and Tissue Aging
Senescence is being treated as a modifiable driver of tissue decline, impaired regeneration and treatment response. IGFBP5 and non-canonical Wnt signaling reverse dental follicle stem-cell senescence, while hepassocin activates AMPK to support liver regeneration. LSD1-mediated ATM demethylation links DNA-damage signaling to organ aging, and therapy-induced senescence in acute myeloid leukemia may increase immunogenicity through reduced EZH2 activity. The work is moving toward pathway-specific strategies that either prevent senescence or exploit it therapeutically.
5 papers · 50%
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Inflammation and Tissue Aging
Inflammatory signaling is being targeted alongside tissue repair and cellular aging. Biomimetic and platelet-membrane vesicles deliver resveratrol or other payloads to limit neuroinflammation, mitochondrial dysfunction and endothelial senescence. Macrophage polarization and redox-inflammatory signaling recur as links between local injury and broader tissue decline. Glycine studies add a systemic perspective, associating slower biological aging with sex- and diet-dependent inflammatory effects, but their evidence is less interventional.
3 papers · 30%
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Senescence-Targeted Cancer Immunotherapy
Cancer research is moving toward using senescence as both a therapeutic target and a biomarker for immune treatment selection. Nanotherapies aim to eliminate or modulate senescent cells, while pan-cancer multi-omics seeks signatures that predict immunotherapy response. Human cytotoxic T-cell activity and the interaction between senescent cancer cells and immune surveillance remain central to translation. Clinical utility will depend on validating these signatures and showing that senescence-directed treatment improves survival rather than merely changing immune profiles.
2 papers · 20%
Senescence can function as an antitumor immune state rather than merely a pathological state to eliminate
Acute myeloid leukemia subjected to chemotherapy and pan-cancer tumors analyzed by multi-omics both indicate that senescence can be associated with, and potentially strengthen, antitumor immunity rather than simply impair tissue function or promote disease. In AML, therapy-induced senescence increased interferon signaling, HLA expression, antigen presentation, T-cell activation, and sensitivity to checkpoint blockade; across 31 cancers, higher senescence scores were associated with greater CD8⁺ T-cell and NK-cell infiltration, immune cytolytic activity, and features relevant to immunotherapy response 42697881Sep 42722723Sep. This replaces the assumption that senescence is uniformly a detrimental state to suppress with a context-dependent view in which inducing or preserving senescence may sometimes improve immune recognition and cancer treatment.
Papers
The 10 papers from the last 6 months that study senescence directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Cellular Senescence and Tissue Aging (5)
- LSD1-mediated demethylation of the DNA damage response factor ATM promotes senescence and organ aging. The Journal of clinical investigation · 15 Sept 2026 PMID 42741942
- Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK. Signal transduction and targeted therapy · 14 Sept 2026 PMID 42736285
- IGFBP5 alleviates periodontitis by reversing human dental follicle stem cell senescence via the non-canonical Wnt pathway. International journal of oral science · 14 Sept 2026 PMID 42736271
- The Senescent Phenotype of Cultured Hypothalamic Astrocytes from Rats with Streptozotocin-Induced Dementia. Neurochemical research · 11 Sept 2026 PMID 42726406
- Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity. Nature communications · 4 Sept 2026 PMID 42697881
Inflammation and Tissue Aging (3)
- A biomimetic hybrid membrane vesicle nanoplatform attenuates tendinopathy through neuroinflammation modulation and tendon regeneration. Cell reports. Medicine · 23 Jul 2026 PMID 42492519
- Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation. Aging cell · 21 Jul 2026 PMID 42479952
- Plasma glycine decelerates biological aging via the redox-inflammatory axis: A large-scale study modulated by sex and dietary patterns. Free radical biology & medicine · 9 May 2026 PMID 42105789
Senescence-Targeted Cancer Immunotherapy (2)
- Nanotherapy against senescence. Science (New York, N.Y.) · 24 Sept 2026 PMID 42784700
- Clinical translation of senescence-related pan-cancer multi-omics: tools for assessment and immunotherapy prediction. Cancer gene therapy · 10 Sept 2026 PMID 42722723
By study type
Human data, design not indexed (1)
- Plasma glycine decelerates biological aging via the redox-inflammatory axis: A large-scale study modulated by sex and dietary patterns. Free radical biology & medicine · 9 May 2026 PMID 42105789
Preclinical: animal, cell and lab studies (8)
- Nanotherapy against senescence. Science (New York, N.Y.) · 24 Sept 2026 PMID 42784700
- LSD1-mediated demethylation of the DNA damage response factor ATM promotes senescence and organ aging. The Journal of clinical investigation · 15 Sept 2026 PMID 42741942
- Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK. Signal transduction and targeted therapy · 14 Sept 2026 PMID 42736285
- IGFBP5 alleviates periodontitis by reversing human dental follicle stem cell senescence via the non-canonical Wnt pathway. International journal of oral science · 14 Sept 2026 PMID 42736271
- The Senescent Phenotype of Cultured Hypothalamic Astrocytes from Rats with Streptozotocin-Induced Dementia. Neurochemical research · 11 Sept 2026 PMID 42726406
- Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity. Nature communications · 4 Sept 2026 PMID 42697881
- A biomimetic hybrid membrane vesicle nanoplatform attenuates tendinopathy through neuroinflammation modulation and tendon regeneration. Cell reports. Medicine · 23 Jul 2026 PMID 42492519
- Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation. Aging cell · 21 Jul 2026 PMID 42479952
Unclassified: not yet indexed with MeSH (1)
- Clinical translation of senescence-related pan-cancer multi-omics: tools for assessment and immunotherapy prediction. Cancer gene therapy · 10 Sept 2026 PMID 42722723
Written from 10 PubMed abstracts, each one listed by PMID above. Published: 2026-09-26. Drafted by language models from published abstracts; not medical advice.