Angiogenesis
Angiogenesis is the biological process through which new blood vessels form from pre-existing vasculature.
Angiogenesis is the biological process through which new blood vessels form from pre-existing vasculature. It is regulated by coordinated endothelial-cell activation, proliferation, migration, extracellular-matrix remodeling, and maturation of vascular structures. Vascular endothelial growth factor (VEGF) is a major pro-angiogenic signal, while tissue oxygenation, inflammation, reactive oxygen species, macrophage activity, and pathways such as HIF-1α influence the balance between vascular growth and regression.
Physiological angiogenesis contributes to wound healing, tissue regeneration, and tissue remodeling, including vascular repair after ischemic injury. In pathological settings, excessive or disorganized angiogenesis can support tumor growth and progression, whereas inadequate angiogenesis may limit repair in ischemic or injured tissues. Consequently, angiogenesis is both a therapeutic objective—when vascularization is desired—and a treatment target, particularly in cancer. Experimental studies commonly assess angiogenesis through endothelial-cell migration and proliferation, vascular markers such as CD31, and the formation of vascular structures in biomaterials or tissue models.
Rebuilt from PubMed 10 Sept 2026 · no new papers today
Where the papers sit
9 papers study angiogenesis directly. Those 9 do not group into themes. Vascular growth modulation appears across cancer therapy, ischemic repair, biomaterials, and natural products. The set combines pro- and anti-angiogenic aims, including VEGF delivery, HIF-1α/CPT1 signaling, tubulin inhibition, sunitinib, lenvatinib, and PD-L1 blockade, without a common direction. They are no more alike than papers drawn from anywhere in the corpus. 1 paradigm shift follows.
Angiogenesis is presented as a therapeutic means of tissue repair rather than solely a process to suppress
The supramolecular hydrogel study of infarcted myocardium, the Danshen–Chuanxiong study in cerebral ischemia, and the protocatechualdehyde–taurine nanoparticle study of oral ulcers each treat angiogenesis as beneficial in a noncancer injury model: sustained VEGF delivery improved post-infarct repair, the herb pair alleviated cerebral ischemia while regulating angiogenesis, and the nanoparticles promoted vascularization and ulcer healing 42492872Jul 42431282Jul 41989033Apr. Against the cancer-focused use of angiogenesis inhibition elsewhere in the set, these distinct disease models and interventions indicate that the therapeutic objective is context-dependent: restoring or promoting vascular growth can itself be part of treatment when tissue ischemia or mucosal injury is the problem.
Recent Findings on angiogenesis
In lung adenocarcinoma, a study examined the interaction between angiogenesis and antitumor immunity in a treatment strategy combining lenvatinib, radiotherapy, and PD-L1 blockade. The cited preclinical evidence indicated that lenvatinib enhanced the efficacy of the combined treatment by modulating both angiogenesis and antitumor immunity, linking vascular-targeted therapy with immune checkpoint inhibition 42708433Sep.
A supramolecular recognition-based hydrogel was investigated for infarcted myocardial repair. The material incorporated VEGF and hesperadin, a CaMKII inhibitor. The publication context identifies hesperadin as having anti-apoptotic activity and VEGF as promoting angiogenesis after myocardial infarction, supporting a combined biomaterial approach directed at cell survival, vascular growth, and tissue repair 42492872Jul. The study is situated within broader efforts to use hydrogels to deliver bioactive factors for cardiac regeneration.
Combretastatin A4–chalcone hybrids were designed and synthesized as tubulin polymerization inhibitors. The compounds were evaluated not only for cytotoxic activity and tubulin inhibition but also for anti-angiogenic properties, reflecting the use of vascular growth inhibition as a complementary mechanism in anticancer drug discovery 42647402Aug.
Menstrual blood stem cell-derived exosomes were studied for their effects on breast cancer cell behavior, with particular attention to apoptosis, migration, and angiogenesis. The work therefore examined whether exosome-mediated signaling could influence several processes relevant to tumor biology, including cancer-cell movement and vascular development 42159846May. Its stated focus connects angiogenesis with cellular migration and programmed cell death rather than treating vascular growth as an isolated endpoint.
In liver transplant recipients with recurrent or newly developing liver cancer, a study evaluated lenvatinib together with an anti-PD-L1 agent. Lenvatinib was used as an angiogenesis-directed treatment, while PD-L1 inhibition represented the immunotherapeutic component of the combination 42262196Jun. The publication therefore reflects a therapeutic strategy that couples suppression of tumor-associated vascularization with modulation of antitumor immunity.
An injectable, pH-responsive gelatin methacryloyl hydrogel was developed for clear cell renal cell carcinoma. The approach combined cuproptosis-related therapy, immune reprogramming, and sunitinib treatment. Within this combination, sunitinib was described as inhibiting angiogenesis and acting synergistically with copper-driven immunomodulation to promote a tumor-suppressive M1 macrophage phenotype 42392517Jul. The study integrates vascular targeting with macrophage biology, immune response, and hydrogel-based delivery.
Natural polyphenol–taurine-based nanoparticles were investigated for oral-ulcer therapy. The reported therapeutic profile included reactive oxygen species scavenging, lipopolysaccharide neutralization, mitochondrial protection, modulation of macrophage polarization, promotion of anti-inflammatory activity, and enhancement of cell migration and angiogenesis 41989033Apr. In this context, angiogenesis was considered part of a broader wound-healing response involving inflammation, macrophages, tissue regeneration, and wound closure.
Danshen–Chuanxiong treatment was studied in cerebral ischemia using integrated multi-omics analysis. The analysis identified significant enrichment of pathways associated with carnitine metabolism and angiogenesis, and the study examined these effects in relation to activation of the CPT1/HIF-1α signaling axis 42431282Jul. This work places angiogenesis within a metabolic and hypoxia-responsive framework for ischemic brain injury.
Taken together, the recent publications extend the literature’s broad theme of diverse vascular therapeutics rather than defining a single unified experimental direction. They represent angiogenesis as a modifiable process in cancer, myocardial infarction, cerebral ischemia, oral-ulcer healing, and tissue-engineering applications, using small molecules, immune combinations, exosomes, nanoparticles, hydrogels, and herbal interventions. Across these settings, angiogenesis is investigated alongside endothelial-cell behavior, VEGF signaling, macrophage activity, inflammation, migration, and tissue remodeling.
Written from 9 PubMed abstracts, each one cited by PMID above. Published: 2026-09-10. Drafted by language models from published abstracts; not medical advice.