Taurine
Taurine is a sulfur-containing organic compound, chemically known as 2-aminoethanesulfonic acid.
Taurine is a sulfur-containing organic compound, chemically known as 2-aminoethanesulfonic acid. In biomedical research, it is commonly discussed as a conditionally essential amino acid-like molecule with roles in osmoregulation, membrane stabilization, antioxidant defense, and modulation of inflammatory and metabolic pathways. Although it is not incorporated into proteins, taurine is widely studied for its physiological importance in tissues with high metabolic demand and in conditions involving oxidative stress, inflammation, and impaired cellular homeostasis.
As a therapeutic research entity, taurine has attracted attention in metabolic disease, tissue repair, and aging-related biology. Recent studies have examined its use as a supplement, a bioactive component in drug-delivery systems, and a mechanistic probe of signaling pathways such as high mobility group box 1 (HMGB1)/toll like receptor 4 (TLR4)/MyD88/NF-κB and p38 MAPK. These investigations place taurine at the intersection of inflammation control, metabolic regulation, and regenerative medicine, including diabetic wound healing, diabetic nephropathy, oral ulcer therapy, and cellular senescence research.
Where the papers sit
9 papers from the last 6 months study taurine directly · updated from PubMed 1 Nov 2026
Study type 1 clinical trial · 2 observational · 1 human data · 5 preclinical
Themes one subject
Those 9 are all about one subject.
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Taurine in Aging and Health
Taurine research is moving toward a broad health-span question spanning metabolism, neurobiology, intestinal injury, bone loss and cognitive aging. Preclinical work repeatedly links supplementation with AMPK/ACC, BDNF/TrkB/ERK1/CREB signaling and protection from high-fat diet, irradiation or neglect-related injury. Human evidence remains early, with metabolic associations and a blinded supplementation trial focused on biological aging. Alzheimer disease tau biomarkers and aggregation studies appear alongside this theme but do not yet establish a taurine-specific clinical pathway.
Papers
The 9 papers from the last 6 months that study taurine directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Taurine in Aging and Health (9)
- Association between fish-related metabolites and metabolic syndrome risk factors in Japan: INTERLIPID metabolome -wide association study. European journal of nutrition · 30 Jul 2026 PMID 42530704
- Taurine mitigates intestinal injury and spatial memory deficits induced by high-fat diet and abdominal irradiation. Life sciences · 29 Jul 2026 PMID 42526595
- Hypercholesterolemia induced by hypothyroidism is ameliorated by taurine supplementation through the hepatic AMPK/ACC pathway. Archives of endocrinology and metabolism · 22 Jul 2026 PMID 42485573
- Taurine modulates hippocampal BDNF/TrkB/ERK1/CREB signaling and behavioral outcomes in a model of early life neglect. Behavioural brain research · 10 Jul 2026 PMID 42431380
- Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association · 29 Jun 2026 PMID 42373580
- Combined metformin and Taurine attenuate age-related bone loss. Molecular biology reports · 27 Jun 2026 PMID 42364025
- Elimination of tau tangles and soluble aggregates with the small molecule ACI-16664 prevents neurodegeneration in vivo. Alzheimer's & dementia : the journal of the Alzheimer's Association · 27 Jun 2026 PMID 42363714
- Plasma and CSF adiponectin levels in biomarker-confirmed Alzheimer's disease: A cross-sectional study in a tertiary memory clinic. Metabolic brain disease · 26 Jun 2026 PMID 42360686
- Effects of taurine supplementation on metabolic health and biological aging in healthcare workers: A protocol for a triple-blinded, Bayesian-optimized phase II randomized controlled trial. PloS one · 27 May 2026 PMID 42201902
By study type
Clinical trials (1)
- Effects of taurine supplementation on metabolic health and biological aging in healthcare workers: A protocol for a triple-blinded, Bayesian-optimized phase II randomized controlled trial. PloS one · 27 May 2026 PMID 42201902
Observational studies and case reports (2)
- Association between fish-related metabolites and metabolic syndrome risk factors in Japan: INTERLIPID metabolome -wide association study. European journal of nutrition · 30 Jul 2026 PMID 42530704
- Plasma and CSF adiponectin levels in biomarker-confirmed Alzheimer's disease: A cross-sectional study in a tertiary memory clinic. Metabolic brain disease · 26 Jun 2026 PMID 42360686
Human data, design not indexed (1)
- Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association · 29 Jun 2026 PMID 42373580
Preclinical: animal, cell and lab studies (5)
- Taurine mitigates intestinal injury and spatial memory deficits induced by high-fat diet and abdominal irradiation. Life sciences · 29 Jul 2026 PMID 42526595
- Hypercholesterolemia induced by hypothyroidism is ameliorated by taurine supplementation through the hepatic AMPK/ACC pathway. Archives of endocrinology and metabolism · 22 Jul 2026 PMID 42485573
- Taurine modulates hippocampal BDNF/TrkB/ERK1/CREB signaling and behavioral outcomes in a model of early life neglect. Behavioural brain research · 10 Jul 2026 PMID 42431380
- Combined metformin and Taurine attenuate age-related bone loss. Molecular biology reports · 27 Jun 2026 PMID 42364025
- Elimination of tau tangles and soluble aggregates with the small molecule ACI-16664 prevents neurodegeneration in vivo. Alzheimer's & dementia : the journal of the Alzheimer's Association · 27 Jun 2026 PMID 42363714
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-06-15. Last written: 2026-08-26 by GPT. Drafted by language models from published abstracts; not medical advice.