W
bioLLM/wiki

AI-Curated Biotech/Medical Knowledge Base
Live
Back to List View Graph View

Colorectal cancer

Colorectal cancer (CRC) is a malignant disease arising in the colon or rectum.

Where the papers sit

27 papers from the last 6 months study colorectal cancer directly · updated from PubMed 3 Nov 2026

Study type 0 clinical trials · 9 observational · 6 human data · 10 preclinical · 2 unclassified

Themes one subject · 1 new direction

Those 27 are all about one subject.

  • Colorectal Cancer Care and Outcomes

    Prognosis, treatment, and care delivery are examined across colorectal cancer, from oligometastatic classification and molecular risk signatures to robotic surgery and access. Studies test markers linked to m6A, cuproptosis, propionate metabolism, and immune features, but no single biomarker strategy dominates. Experimental work explores measles-mumps vaccines and KRAS-AGO2 disruption to improve treatment sensitivity. The cluster is united by outcome improvement, while its clinical and laboratory approaches remain too varied to define a shared therapeutic direction.

    27 papers

NEW DIRECTION

Colorectal cancer is shown as a systemic suppressor of atherosclerosis, not only a disease to treat

The study of colorectal cancer–atherosclerosis comorbidity found that tumors reduced atherosclerotic plaque burden and increased plaque stability in patients and in three mouse models, because tumor-driven arginine depletion reprogrammed plaque T cells toward oxidative phosphorylation, weakening cytotoxic and pro-inflammatory interactions 42608528Aug. This assigns colorectal cancer a role outside the set’s usual treatment, diagnosis, prognosis, and perioperative-care categories: it acts as a systemic modifier of another disease, suggesting that tumor metabolism can reshape—and in this case suppress—atherogenesis.

Papers

The 27 papers from the last 6 months that study colorectal cancer directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.

By theme

Colorectal Cancer Care and Outcomes (27)
  1. Prognostic Significance of the ESTRO/EORTC Classification of Oligometastatic Disease for Colorectal Cancer Patients With Uncommon Metastases Treated With Definitive Radiotherapy. In vivo (Athens, Greece) · 29 Oct 2026 PMID 42957241
  2. Transcriptomics analysis and experimental assay to screen prognostic genes of N6-methyladenosine RNA methylation related to cuproptosis in colorectal cancer. Medical oncology (Northwood, London, England) · 20 Oct 2026 PMID 42900322
  3. Robotic colorectal cancer surgery: perioperative and oncological outcomes at a national referral center in Mexico. Journal of robotic surgery · 11 Oct 2026 PMID 42860519
  4. A propionate metabolism-related gene signature predicts prognosis and immunological features in colorectal cancer. Medical oncology (Northwood, London, England) · 8 Oct 2026 PMID 42848099
  5. Association between cachexia-associated diagnoses, health care resource utilization, and costs in patients with pancreatic, lung, and colorectal cancers: A US insurance claims database analysis. Journal of managed care & specialty pharmacy · 29 Sept 2026 PMID 42808542
  6. Comparison of an ensemble machine learning model to a Cox regression model to predict colorectal cancer risk among people with HIV using retrospective nationwide cohort data in Sweden: a study protocol. BMJ open · 9 Sept 2026 PMID 42716689
  7. Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression. PLoS computational biology · 8 Sept 2026 PMID 42709882
  8. Anti-cancer efficacy of combined vaccine-strain measles and mumps viruses against colorectal cancer: an experimental study. Molecular biology reports · 5 Sept 2026 PMID 42700211
  9. Timeliness of Colorectal Cancer Care in Veterans: The Role of Travel Distance. Cancer reports (Hoboken, N.J.) · 31 Aug 2026 PMID 42675007
  10. Multi-omics Investigations of Immune Microenvironment of Human Colorectal Cancer. Cancer genomics & proteomics · 31 Aug 2026 PMID 42674818
  11. Tobacco and Opium Use and Risk of Liver and Colorectal Cancer Mortality: Analysis of the Golestan Cohort Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 31 Aug 2026 PMID 42671160
  12. Factors Affecting Postoperative Delirium in Patients With Colorectal Cancer. In vivo (Athens, Greece) · 28 Aug 2026 PMID 42665375
  13. Serum Pharmacochemistry Combined With Network Pharmacology to Explore Potential Bioactive Components and Mechanisms of Pomegranate Peel in the Treatment of Colorectal Cancer. Biomedical chromatography : BMC · 25 Aug 2026 PMID 42642018
  14. Establishing a sustainable and high-utilization robot-assisted surgery platform in a regional cancer center: insights from a multidisciplinary, break-even-guided operational strategy. Journal of robotic surgery · 21 Aug 2026 PMID 42627549
  15. Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids. Journal of medicinal chemistry · 20 Aug 2026 PMID 42623604
  16. Disrupting KRAS-AGO2 interaction: a dual-pronged strategy to sensitize chemo-immunotherapy in KRAS-mutated colorectal cancer. Apoptosis : an international journal on programmed cell death · 20 Aug 2026 PMID 42622908
  17. Tumor-driven arginine depletion induces T-cell metabolism reprogramming to suppress atherosclerosis in colorectal cancer. Acta pharmacologica Sinica · 18 Aug 2026 PMID 42608528
  18. Modeling microbiome modulation of tumor metabolic networks to predict synergistic therapies. Cell reports methods · 13 Aug 2026 PMID 42594868
  19. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer. Cell · 4 Aug 2026 PMID 42551424
  20. Combining fruquintinib with TAS-102 as a promising strategy: antitumor activity in preclinical colorectal and gastric cancer xenograft models. BMC cancer · 31 Jul 2026 PMID 42533327
  21. Pattern of opioid prescriptions among patients with breast, lung, and colorectal cancer diagnosed with pre-existing chronic non-cancer pain. PloS one · 29 Jul 2026 PMID 42525681
  22. Reduced-port robot radical colorectal cancer surgery a prospective trial and standardized port strategy. Journal of robotic surgery · 20 Jul 2026 PMID 42474928
  23. Anti-tumor effects of CD133-targeted CAR-NK92MI cells in colorectal cancer. Cytotherapy · 16 Jul 2026 PMID 42462589
  24. 5-Fluorouracil loaded copper-aluminum layered double hydroxides inhibit colorectal cancer cells by inducing oxidative stress, mitochondrial membrane depolarization, apoptosis, and cell cycle arrest. Bioorganic chemistry · 15 Jul 2026 PMID 42456411
  25. Disease-specific gut microbial signatures generate model-derived cancer probability scores through targeted fecal qPCR profiling. Bioscience, biotechnology, and biochemistry · 18 Jun 2026 PMID 42315484
  26. Ultrasound-programmable tumor extracellular vesicles delivery system for dual immune-epigenetic therapy against colorectal cancer metastasis. Journal of controlled release : official journal of the Controlled Release Society · 17 Jun 2026 PMID 42309466
  27. In vitro and in vivo anti-colorectal cancer properties and potential mechanisms of Lemmaphyllum drymoglossoides essential oil. Journal of ethnopharmacology · 7 May 2026 PMID 42092475

By study type

Observational studies and case reports (9)
  1. Prognostic Significance of the ESTRO/EORTC Classification of Oligometastatic Disease for Colorectal Cancer Patients With Uncommon Metastases Treated With Definitive Radiotherapy. In vivo (Athens, Greece) · 29 Oct 2026 PMID 42957241
  2. Robotic colorectal cancer surgery: perioperative and oncological outcomes at a national referral center in Mexico. Journal of robotic surgery · 11 Oct 2026 PMID 42860519
  3. Association between cachexia-associated diagnoses, health care resource utilization, and costs in patients with pancreatic, lung, and colorectal cancers: A US insurance claims database analysis. Journal of managed care & specialty pharmacy · 29 Sept 2026 PMID 42808542
  4. Comparison of an ensemble machine learning model to a Cox regression model to predict colorectal cancer risk among people with HIV using retrospective nationwide cohort data in Sweden: a study protocol. BMJ open · 9 Sept 2026 PMID 42716689
  5. Timeliness of Colorectal Cancer Care in Veterans: The Role of Travel Distance. Cancer reports (Hoboken, N.J.) · 31 Aug 2026 PMID 42675007
  6. Tobacco and Opium Use and Risk of Liver and Colorectal Cancer Mortality: Analysis of the Golestan Cohort Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 31 Aug 2026 PMID 42671160
  7. Factors Affecting Postoperative Delirium in Patients With Colorectal Cancer. In vivo (Athens, Greece) · 28 Aug 2026 PMID 42665375
  8. Pattern of opioid prescriptions among patients with breast, lung, and colorectal cancer diagnosed with pre-existing chronic non-cancer pain. PloS one · 29 Jul 2026 PMID 42525681
  9. Reduced-port robot radical colorectal cancer surgery a prospective trial and standardized port strategy. Journal of robotic surgery · 20 Jul 2026 PMID 42474928
Human data, design not indexed (6)
  1. Transcriptomics analysis and experimental assay to screen prognostic genes of N6-methyladenosine RNA methylation related to cuproptosis in colorectal cancer. Medical oncology (Northwood, London, England) · 20 Oct 2026 PMID 42900322
  2. A propionate metabolism-related gene signature predicts prognosis and immunological features in colorectal cancer. Medical oncology (Northwood, London, England) · 8 Oct 2026 PMID 42848099
  3. Multi-omics Investigations of Immune Microenvironment of Human Colorectal Cancer. Cancer genomics & proteomics · 31 Aug 2026 PMID 42674818
  4. Establishing a sustainable and high-utilization robot-assisted surgery platform in a regional cancer center: insights from a multidisciplinary, break-even-guided operational strategy. Journal of robotic surgery · 21 Aug 2026 PMID 42627549
  5. Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids. Journal of medicinal chemistry · 20 Aug 2026 PMID 42623604
  6. Disease-specific gut microbial signatures generate model-derived cancer probability scores through targeted fecal qPCR profiling. Bioscience, biotechnology, and biochemistry · 18 Jun 2026 PMID 42315484
Preclinical: animal, cell and lab studies (10)
  1. Anti-cancer efficacy of combined vaccine-strain measles and mumps viruses against colorectal cancer: an experimental study. Molecular biology reports · 5 Sept 2026 PMID 42700211
  2. Serum Pharmacochemistry Combined With Network Pharmacology to Explore Potential Bioactive Components and Mechanisms of Pomegranate Peel in the Treatment of Colorectal Cancer. Biomedical chromatography : BMC · 25 Aug 2026 PMID 42642018
  3. Disrupting KRAS-AGO2 interaction: a dual-pronged strategy to sensitize chemo-immunotherapy in KRAS-mutated colorectal cancer. Apoptosis : an international journal on programmed cell death · 20 Aug 2026 PMID 42622908
  4. Modeling microbiome modulation of tumor metabolic networks to predict synergistic therapies. Cell reports methods · 13 Aug 2026 PMID 42594868
  5. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer. Cell · 4 Aug 2026 PMID 42551424
  6. Combining fruquintinib with TAS-102 as a promising strategy: antitumor activity in preclinical colorectal and gastric cancer xenograft models. BMC cancer · 31 Jul 2026 PMID 42533327
  7. Anti-tumor effects of CD133-targeted CAR-NK92MI cells in colorectal cancer. Cytotherapy · 16 Jul 2026 PMID 42462589
  8. 5-Fluorouracil loaded copper-aluminum layered double hydroxides inhibit colorectal cancer cells by inducing oxidative stress, mitochondrial membrane depolarization, apoptosis, and cell cycle arrest. Bioorganic chemistry · 15 Jul 2026 PMID 42456411
  9. Ultrasound-programmable tumor extracellular vesicles delivery system for dual immune-epigenetic therapy against colorectal cancer metastasis. Journal of controlled release : official journal of the Controlled Release Society · 17 Jun 2026 PMID 42309466
  10. In vitro and in vivo anti-colorectal cancer properties and potential mechanisms of Lemmaphyllum drymoglossoides essential oil. Journal of ethnopharmacology · 7 May 2026 PMID 42092475
Unclassified: not yet indexed with MeSH (2)
  1. Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression. PLoS computational biology · 8 Sept 2026 PMID 42709882
  2. Tumor-driven arginine depletion induces T-cell metabolism reprogramming to suppress atherosclerosis in colorectal cancer. Acta pharmacologica Sinica · 18 Aug 2026 PMID 42608528
bioLLM/wiki is a literature-navigation aid for people who read primary research. It is not a medical resource, and it is not a substitute for a clinician, a pharmacist or the source papers themselves. Because the articles are drafted by language models, they can be incomplete or wrong in ways that read fluently. Please see the editorial policy and medical disclaimer before relying on anything here.

Written from 27 PubMed abstracts, each one listed by PMID above. Published: 2026-08-23. Last written: 2026-09-11 by GPT. Drafted by language models from published abstracts; not medical advice.