Lipid nanoparticle
lipid nanoparticles (LNPs) are nanoscale, lipid-based delivery systems used primarily to transport therapeutic cargo such as messenger RNA, small interfering RNA, and other nucleic acids into cells.
lipid nanoparticles (LNPs) are nanoscale, lipid-based delivery systems used primarily to transport therapeutic cargo such as messenger RNA, small interfering RNA, and other nucleic acids into cells. In biomedical applications, they are valued for protecting payloads from degradation, enabling cellular uptake, and supporting endosomal escape after internalization. Their composition commonly includes ionizable lipid, cholesterol, helper lipids, and polyethylene glycol-lipids, with formulation parameters strongly influencing encapsulation efficiency, biodistribution, and immunogenicity.
In medicine, lipid nanoparticles are especially important as nonviral carriers for RNA therapeutics and gene editing payloads. Their clinical and translational relevance extends to liver-directed delivery and increasingly to extrahepatic tissues, including the retina, heart, bladder, and immune cells. Recent work has focused on improving organ specificity, reducing proinflammatory cytokine responses, and optimizing manufacturing methods to improve scalability and reproducibility for clinical translation.
Where the papers sit
14 papers from the last 6 months study lipid nanoparticle directly · updated from PubMed 5 Oct 2026
Study type 0 clinical trials · 7 preclinical · 7 unclassified
Themes one subject
Those 14 are all about one subject.
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Targeted mRNA Delivery
Application-specific mRNA delivery is moving toward organ- and cell-selective lipid nanoparticles rather than broadly distributed formulations. Glycan structures, mannosylation and ionizable-lipid design are being used to target spleen antigen-presenting cells, T cells, macrophages, cardiomyocytes and the injured brain. Process variables such as dilution, microfluidic mixing, freezing and lyophilization increasingly determine particle structure, potency and reconstitution. The field is converging on targeted therapeutic and vaccine applications, but optimal designs remain tissue- and payload-dependent.
Papers
The 14 papers from the last 6 months that study lipid nanoparticle directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Targeted mRNA Delivery (14)
- Tailoring lipid nanoparticles for application-specific mRNA delivery. Journal of controlled release : official journal of the Controlled Release Society · 21 Sept 2026 PMID 42767379
- Stepwise neutrophil-to-neuron targeting nanotherapy for mitochondrial protection and blood-brain barrier preservation in ischemic stroke. Journal of controlled release : official journal of the Controlled Release Society · 19 Sept 2026 PMID 42762842
- Dilution mode acts as a critical process parameter that reprograms lipid nanoparticle assembly and in vivo mRNA delivery. Journal of controlled release : official journal of the Controlled Release Society · 16 Sept 2026 PMID 42749133
- Mannosylated Spleen-Targeted Lipid Nanoparticles Enable Enhanced mRNA Delivery to Antigen-Presenting Cells. ACS biomaterials science & engineering · 14 Sept 2026 PMID 42733201
- Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte-mediated cancer immunotherapy. Science advances · 11 Sept 2026 PMID 42726873
- A perspective on targeted LNPs. Journal of controlled release : official journal of the Controlled Release Society · 9 Sept 2026 PMID 42716129
- An Investigation of Water Vapor Sorption for Improving Reconstitution Pathways of Freeze-Dried Lipid Nanoparticles Stabilized by Trehalose/Mannitol Excipients. AAPS PharmSciTech · 9 Sept 2026 PMID 42711609
- A double-amine ionizable lipid library enables highly efficient mRNA delivery to T cells at reduced lipid mass. Biomaterials science · 18 Aug 2026 PMID 42610355
- Gravity-driven microfluidic synthesis of lipid nanoparticles via vibrating sharp-tip mixing. Biofabrication · 4 Aug 2026 PMID 42551456
- Evaluation of lipid nanoparticle adjuvants with different PEG lipid ratios and phospholipid modifications in non-human primates. Molecular therapy. Nucleic acids · 28 Jul 2026 PMID 42519570
- Preliminary study on intravesical instillation of IL-12 mRNA lipid nanoparticles for the treatment of bladder cancer. Tumori · 24 Jul 2026 PMID 42494051
- Loss of internal structural order induced by freezing and lyophilization correlates with reduced in vitro activity of mRNA lipid nanoparticles. Journal of controlled release : official journal of the Controlled Release Society · 30 Jun 2026 PMID 42379312
- A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing. Proceedings of the National Academy of Sciences of the United States of America · 18 May 2026 PMID 42150080
- Glycan Chemical Structures Dictate Organ- and Cell-Specific Tropism and Immunomodulation of Lipid Nanoparticles. ACS nano · 16 Apr 2026 PMID 41989838
By study type
Preclinical: animal, cell and lab studies (7)
- Mannosylated Spleen-Targeted Lipid Nanoparticles Enable Enhanced mRNA Delivery to Antigen-Presenting Cells. ACS biomaterials science & engineering · 14 Sept 2026 PMID 42733201
- Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte-mediated cancer immunotherapy. Science advances · 11 Sept 2026 PMID 42726873
- An Investigation of Water Vapor Sorption for Improving Reconstitution Pathways of Freeze-Dried Lipid Nanoparticles Stabilized by Trehalose/Mannitol Excipients. AAPS PharmSciTech · 9 Sept 2026 PMID 42711609
- Gravity-driven microfluidic synthesis of lipid nanoparticles via vibrating sharp-tip mixing. Biofabrication · 4 Aug 2026 PMID 42551456
- Loss of internal structural order induced by freezing and lyophilization correlates with reduced in vitro activity of mRNA lipid nanoparticles. Journal of controlled release : official journal of the Controlled Release Society · 30 Jun 2026 PMID 42379312
- A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing. Proceedings of the National Academy of Sciences of the United States of America · 18 May 2026 PMID 42150080
- Glycan Chemical Structures Dictate Organ- and Cell-Specific Tropism and Immunomodulation of Lipid Nanoparticles. ACS nano · 16 Apr 2026 PMID 41989838
Unclassified: not yet indexed with MeSH (7)
- Tailoring lipid nanoparticles for application-specific mRNA delivery. Journal of controlled release : official journal of the Controlled Release Society · 21 Sept 2026 PMID 42767379
- Stepwise neutrophil-to-neuron targeting nanotherapy for mitochondrial protection and blood-brain barrier preservation in ischemic stroke. Journal of controlled release : official journal of the Controlled Release Society · 19 Sept 2026 PMID 42762842
- Dilution mode acts as a critical process parameter that reprograms lipid nanoparticle assembly and in vivo mRNA delivery. Journal of controlled release : official journal of the Controlled Release Society · 16 Sept 2026 PMID 42749133
- A perspective on targeted LNPs. Journal of controlled release : official journal of the Controlled Release Society · 9 Sept 2026 PMID 42716129
- A double-amine ionizable lipid library enables highly efficient mRNA delivery to T cells at reduced lipid mass. Biomaterials science · 18 Aug 2026 PMID 42610355
- Evaluation of lipid nanoparticle adjuvants with different PEG lipid ratios and phospholipid modifications in non-human primates. Molecular therapy. Nucleic acids · 28 Jul 2026 PMID 42519570
- Preliminary study on intravesical instillation of IL-12 mRNA lipid nanoparticles for the treatment of bladder cancer. Tumori · 24 Jul 2026 PMID 42494051
Written from 14 PubMed abstracts, each one listed by PMID above. Published: 2026-08-13. Last written: 2026-09-21 by GPT. Drafted by language models from published abstracts; not medical advice.