Lipid
Lipids are a broad class of hydrophobic or amphipathic biomolecules that include fats, oils, waxes, phospholipids, sterols, and related compounds.
Lipids are a broad class of hydrophobic or amphipathic biomolecules that include fats, oils, waxes, phospholipids, sterols, and related compounds. They are essential structural and functional components of living systems, serving as major constituents of cellular membranes, energy-storage molecules, signaling mediators, and transport-associated molecules. Because of their chemical diversity, lipids participate in membrane organization, cell communication, inflammation, and metabolic regulation.
In biomedical and nutritional contexts, lipid composition is often used as a marker of food quality, metabolic state, and cellular phenotype. Lipids are also central to modern drug delivery and biotechnology, including lipid nanoparticle for nucleic acid encapsulation and microbial platforms engineered for oil production. Analytical methods such as metabolomics, Raman spectroscopy, and multiomics workflows frequently assess lipid-associated signals alongside proteins, amino acid, glycogen, and other metabolites to characterize biological samples.
Where the papers sit
13 papers from the last 6 months study lipid directly · updated from PubMed 11 Oct 2026
Study type 0 clinical trials · 3 human data · 8 preclinical · 2 unclassified
Themes 3 themes · 2 new directions
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Lipid-Based Drug Delivery
Lipid-based carriers are moving toward more stable, scalable and structurally controlled delivery of mRNA and small-molecule drugs. Freezing and lyophilization can disrupt internal order and reduce mRNA activity, motivating optimized solid formulations and continuous nanopore assembly. PEG-free lipocondensates and polymeric micelles broaden delivery toward prolonged circulation and transdermal transport. Encapsulation efficiency, particle structure and in vitro activity remain central endpoints.
6 papers · 46.2%
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Metabolic Lipid Biology
Lipid and metabolite biology is being linked across breast cancer, obesity, diet and natural-product research. In breast cancer, oxylipin signaling and CDO1-associated ferroptosis connect metabolic state to tumour growth and apoptosis. Metabolomics is also being used to relate urinary carnosine to diet quality and one-carbon metabolism, while lipidomic profiling characterizes medicinal plants. The shared direction is expanded metabolic phenotyping rather than a single therapeutic strategy.
4 papers · 30.8%
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Lipidomic Mass Spectrometry
Lipidomics is moving toward integrated molecular profiling that combines metabolomics, proteomics, phosphoproteomics and glycoproteomics from the same sample. Sequential extraction and small extracellular vesicle analysis extend coverage across molecular classes. Ozonolysis LC-MS adds structural resolution by locating lipid carbon–carbon double bonds. The field is prioritizing accessible workflows that connect broad profiling with precise lipid identification.
3 papers · 23.1%
Adipocyte-derived oxylipin acts as a tissue-level regulator of tumor ferroptosis
The lean-versus-obese mammary adipose and breast-cancer model assumed in this study instead shows that adipocytes secrete the lipid mediator 9S-HODE, which induces ferroptosis in breast-cancer cells by disrupting iron homeostasis; obesity reduces this signal, thereby weakening tumor suppression. Lipid is therefore assigned a causal intertissue signaling role linking adipose state to cancer progression, and restoring the signal becomes a therapeutic strategy 42721252Sep.
Lipid interfaces can stabilize micron-scale condensates for prolonged circulation without PEG
The LipCon lipid-containing condensate delivery model departs from the nanoscale lipid-particle approach by showing that natural lipids can organize a roughly 3-µm condensate surface into a low-mobility, unusually stable interface; these PEG-free structures circulate for about 13 hours, whereas micron-scale liposomes, including PEGylated ones, are unstable. Lipid consequently serves not merely as a nanoparticle carrier or coating but as the structural stabilizer of a cell-sized circulating condensate 42405635Jul.
Papers
The 13 papers from the last 6 months that study lipid directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Lipid-Based Drug Delivery (6)
- Ultrasmall Polymeric Micelles Enable Noninvasive Transdermal Rosiglitazone Delivery via Lipid Fluidization and Transcytosis. Biomacromolecules · 14 Sept 2026 PMID 42734280
- Spray Freeze Drying for Solid Formulations of RNA Lipid Nanoparticles. AAPS PharmSciTech · 10 Sept 2026 PMID 42717177
- Nanopore-Mediated Assembly Enables Precise and Continuous Synthesis of mRNA-Encapsulated Lipid Nanoparticles for COVID-19 Vaccines. ACS nano · 16 Jul 2026 PMID 42462004
- Stable, micron-scale lipocondensates achieving prolonged circulation without PEGlyated lipids. Biomaterials science · 6 Jul 2026 PMID 42405635
- Loss of internal structural order induced by freezing and lyophilization correlates with reduced in vitro activity of mRNA lipid nanoparticles. Journal of controlled release : official journal of the Controlled Release Society · 30 Jun 2026 PMID 42379312
- Structural determination of lipid-bound factor VIII. Journal of thrombosis and haemostasis : JTH · 27 May 2026 PMID 42202884
Metabolic Lipid Biology (4)
- Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis. Science (New York, N.Y.) · 10 Sept 2026 PMID 42721252
- Urinary carnosine links diet quality with one-carbon and lipid metabolism: insights from an interpretive framework for imidazole metabolites. European journal of nutrition · 3 Jul 2026 PMID 42397563
- Upregulation of CDO1 by theaflavin-3,3'-gallate induces apoptosis and inhibits cell proliferation in TNBC. International immunopharmacology · 19 Jun 2026 PMID 42320249
- Lipidome and Targeted Metabolome Analysis of Locational Picrorhiza Kurroa Royle. Ex Benth., Using UPLC-PDA and UHPLC-QTOF-IMS. Rapid communications in mass spectrometry : RCM · 14 Jun 2026 PMID 42288996
Lipidomic Mass Spectrometry (3)
- Multi-omic analyses of the same sample using metabolomics, lipidomics, proteomics, phosphoproteomics, and glycoproteomics. Chemical communications (Cambridge, England) · 20 Aug 2026 PMID 42619640
- Making Ozonolysis Mass Spectrometry More Accessible: A Simple LC-OzESI-MS Workflow for Carbon-Carbon Double Bond Position Elucidation in Lipids and Natural Products. Journal of the American Society for Mass Spectrometry · 27 Jul 2026 PMID 42503838
- Integrated Multiomics Enabled by Sequential Extraction for Comprehensive Molecular Profiling of Small Extracellular Vesicles. Analytical chemistry · 22 Jun 2026 PMID 42330165
By study type
Human data, design not indexed (3)
- Urinary carnosine links diet quality with one-carbon and lipid metabolism: insights from an interpretive framework for imidazole metabolites. European journal of nutrition · 3 Jul 2026 PMID 42397563
- Integrated Multiomics Enabled by Sequential Extraction for Comprehensive Molecular Profiling of Small Extracellular Vesicles. Analytical chemistry · 22 Jun 2026 PMID 42330165
- Structural determination of lipid-bound factor VIII. Journal of thrombosis and haemostasis : JTH · 27 May 2026 PMID 42202884
Preclinical: animal, cell and lab studies (8)
- Ultrasmall Polymeric Micelles Enable Noninvasive Transdermal Rosiglitazone Delivery via Lipid Fluidization and Transcytosis. Biomacromolecules · 14 Sept 2026 PMID 42734280
- Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis. Science (New York, N.Y.) · 10 Sept 2026 PMID 42721252
- Spray Freeze Drying for Solid Formulations of RNA Lipid Nanoparticles. AAPS PharmSciTech · 10 Sept 2026 PMID 42717177
- Making Ozonolysis Mass Spectrometry More Accessible: A Simple LC-OzESI-MS Workflow for Carbon-Carbon Double Bond Position Elucidation in Lipids and Natural Products. Journal of the American Society for Mass Spectrometry · 27 Jul 2026 PMID 42503838
- Stable, micron-scale lipocondensates achieving prolonged circulation without PEGlyated lipids. Biomaterials science · 6 Jul 2026 PMID 42405635
- Loss of internal structural order induced by freezing and lyophilization correlates with reduced in vitro activity of mRNA lipid nanoparticles. Journal of controlled release : official journal of the Controlled Release Society · 30 Jun 2026 PMID 42379312
- Upregulation of CDO1 by theaflavin-3,3'-gallate induces apoptosis and inhibits cell proliferation in TNBC. International immunopharmacology · 19 Jun 2026 PMID 42320249
- Lipidome and Targeted Metabolome Analysis of Locational Picrorhiza Kurroa Royle. Ex Benth., Using UPLC-PDA and UHPLC-QTOF-IMS. Rapid communications in mass spectrometry : RCM · 14 Jun 2026 PMID 42288996
Unclassified: not yet indexed with MeSH (2)
- Multi-omic analyses of the same sample using metabolomics, lipidomics, proteomics, phosphoproteomics, and glycoproteomics. Chemical communications (Cambridge, England) · 20 Aug 2026 PMID 42619640
- Nanopore-Mediated Assembly Enables Precise and Continuous Synthesis of mRNA-Encapsulated Lipid Nanoparticles for COVID-19 Vaccines. ACS nano · 16 Jul 2026 PMID 42462004
Written from 13 PubMed abstracts, each one listed by PMID above. Published: 2026-07-30. Last written: 2026-09-16 by GPT. Drafted by language models from published abstracts; not medical advice.