Diabetic retinopathy
Diabetic retinopathy is a diabetes-related microvascular disease of the retina and a major cause of visual impairment and blindness worldwide, particularly among working-Age adults and older populations.
Diabetic retinopathy is a diabetes-related microvascular disease of the retina and a major cause of visual impairment and blindness worldwide, particularly among working-Age adults and older populations. It arises from chronic metabolic injury to the retinal microvasculature, with early events including pericyte loss, breakdown of the vascular barrier, endothelial dysfunction, inflammation, and abnormal vascular remodeling. As the disease progresses, it can advance to vision-threatening diabetic retinopathy and proliferative diabetic retinopathy, the latter being associated with irreversible complications.
Biologically, diabetic retinopathy is closely linked to hyperglycemia, dysregulated glucose and lipid metabolism, oxidative stress, inflammatory signaling, and angiogenic pathways such as vascular endothelial growth factor A (VEGFA)-mediated responses. Recent studies also implicate molecular regulators including WIF1, HIF1α/PFKFB3 signaling, ANGPTL4, PTTG1, and VE-cadherin phosphorylation in retinal vascular injury and repair. Because diabetic retinopathy can occur even in patients with apparently well-controlled HbA1c, current research increasingly emphasizes broader glycation-related, inflammatory, and metabolic contributors, as well as improved screening and targeted therapies.
Where the papers sit
14 papers from the last 6 months study diabetic retinopathy directly · updated from PubMed 7 Oct 2026
Study type 0 clinical trials · 6 observational · 4 human data · 1 preclinical · 3 unclassified
Themes one subject · 1 new direction
Those 14 are all about one subject.
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Diabetic Eye Disease Research
Earlier detection and risk stratification are central, combining AI-assisted primary-care screening with clinical, genomic, transcriptomic, and retinal imaging measures. Studies assess time in range, rate-pressure product, erythropoietin, prostacyclin analogs, and Asian-population incidence as potential predictors of progression. Links with Alzheimer disease and altered brain activity broaden diabetic retinopathy into a systemic neurovascular disorder. Targeted extracellular-vesicle delivery remains experimental, while prospective validation, cost-effectiveness, and clinically useful biomarkers remain open.
Diabetic retinopathy becomes a cross-disease marker linked to Alzheimer disease
The multilevel genomic, transcriptomic, and epidemiologic study of diabetic retinopathy and Alzheimer disease treats diabetic retinopathy not only as an ocular complication, screening target, treatment target, or prognostic endpoint, but as a genetically and biologically linked correlate of Alzheimer disease. By testing shared genetic loci, expression-mediated genes, cellular pathways, mediation through metabolic and inflammatory traits, and longitudinal Alzheimer disease risk, it gives diabetic retinopathy a cross-disease neurovascular-metabolic role that lies outside the categories used by the other papers 42693903Sep.
Papers
The 14 papers from the last 6 months that study diabetic retinopathy directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Diabetic Eye Disease Research (14)
- Can Artificial Intelligence Deliver in Real-World Health Systems? Early Insights From Augmented Intelligence in Medicine and Healthcare Initiative's 5 Funded Projects. The Permanente journal · 16 Sept 2026 PMID 42745618
- Exploring systemic erythropoietin in diabetic retinopathy: Longitudinal associations and biomarker potential in the LANDMark cohort. PloS one · 15 Sept 2026 PMID 42743350
- Multilevel genomic, transcriptomic, and epidemiologic evidence linking diabetic retinopathy to Alzheimer disease. Journal of global health · 4 Sept 2026 PMID 42693903
- Biological correlates of spontaneous brain activity alterations in diabetic retinopathy: an amplitude of low-frequency fluctuation-based multimodal study. Neuroreport · 14 Aug 2026 PMID 42596900
- Time in tight range and time in range in relation to diabetic retinopathy and OCTA-derived retinal microvascular parameters in hospitalized adults with type 1 diabetes. Endocrine · 3 Aug 2026 PMID 42545593
- Screening for diabetic retinopathy with artificial intelligence in a primary care setting: a comparative cost analysis. BMJ open ophthalmology · 30 Jul 2026 PMID 42532593
- The role of machine learning in early detection, accurate diagnosis, and timely treatment of diseases. Technology and health care : official journal of the European Society for Engineering and Medicine · 28 Jul 2026 PMID 42517779
- Association of rate-pressure product with diabetic retinopathy in patients with type 2 diabetes mellitus: development and internal validation of a nomogram for diabetic retinopathy identification. Endocrine · 10 Jul 2026 PMID 42429883
- Dual DNAzyme-loaded Treg-derived extracellular vesicles for targeted ocular delivery in diabetic retinopathy. International journal of pharmaceutics · 22 Jun 2026 PMID 42331118
- Long-term incidence and progression of vision-threatening diabetic retinopathy in Asian populations. Journal of global health · 19 Jun 2026 PMID 42318791
- PROSTACYCLIN ANALOGS AND DIABETIC RETINOPATHY OUTCOMES IN PATIENTS WITH PULMONARY HYPERTENSION : A Cohort Analysis. Retina (Philadelphia, Pa.) · 17 Jun 2026 PMID 42308470
- The diagnostic accuracy of AI-assisted diabetic retinopathy screening in primary care: a prospective validation study. Scandinavian journal of primary health care · 12 Jun 2026 PMID 42284159
- Plant-based diet quality and risk of age-related eye diseases: evidence from multi-cohorts with multi-omics insights. NPJ science of food · 4 Jun 2026 PMID 42243112
- Comparative assessment of diagnostic agreement between artificial intelligence and general practitioners in diabetic retinopathy screening using non-mydriatic fundus photography. Primary care diabetes · 16 Apr 2026 PMID 41991402
By study type
Observational studies and case reports (6)
- Exploring systemic erythropoietin in diabetic retinopathy: Longitudinal associations and biomarker potential in the LANDMark cohort. PloS one · 15 Sept 2026 PMID 42743350
- Time in tight range and time in range in relation to diabetic retinopathy and OCTA-derived retinal microvascular parameters in hospitalized adults with type 1 diabetes. Endocrine · 3 Aug 2026 PMID 42545593
- Association of rate-pressure product with diabetic retinopathy in patients with type 2 diabetes mellitus: development and internal validation of a nomogram for diabetic retinopathy identification. Endocrine · 10 Jul 2026 PMID 42429883
- PROSTACYCLIN ANALOGS AND DIABETIC RETINOPATHY OUTCOMES IN PATIENTS WITH PULMONARY HYPERTENSION : A Cohort Analysis. Retina (Philadelphia, Pa.) · 17 Jun 2026 PMID 42308470
- The diagnostic accuracy of AI-assisted diabetic retinopathy screening in primary care: a prospective validation study. Scandinavian journal of primary health care · 12 Jun 2026 PMID 42284159
- Comparative assessment of diagnostic agreement between artificial intelligence and general practitioners in diabetic retinopathy screening using non-mydriatic fundus photography. Primary care diabetes · 16 Apr 2026 PMID 41991402
Human data, design not indexed (4)
- Multilevel genomic, transcriptomic, and epidemiologic evidence linking diabetic retinopathy to Alzheimer disease. Journal of global health · 4 Sept 2026 PMID 42693903
- Biological correlates of spontaneous brain activity alterations in diabetic retinopathy: an amplitude of low-frequency fluctuation-based multimodal study. Neuroreport · 14 Aug 2026 PMID 42596900
- Screening for diabetic retinopathy with artificial intelligence in a primary care setting: a comparative cost analysis. BMJ open ophthalmology · 30 Jul 2026 PMID 42532593
- Long-term incidence and progression of vision-threatening diabetic retinopathy in Asian populations. Journal of global health · 19 Jun 2026 PMID 42318791
Preclinical: animal, cell and lab studies (1)
- Dual DNAzyme-loaded Treg-derived extracellular vesicles for targeted ocular delivery in diabetic retinopathy. International journal of pharmaceutics · 22 Jun 2026 PMID 42331118
Unclassified: not yet indexed with MeSH (3)
- Can Artificial Intelligence Deliver in Real-World Health Systems? Early Insights From Augmented Intelligence in Medicine and Healthcare Initiative's 5 Funded Projects. The Permanente journal · 16 Sept 2026 PMID 42745618
- The role of machine learning in early detection, accurate diagnosis, and timely treatment of diseases. Technology and health care : official journal of the European Society for Engineering and Medicine · 28 Jul 2026 PMID 42517779
- Plant-based diet quality and risk of age-related eye diseases: evidence from multi-cohorts with multi-omics insights. NPJ science of food · 4 Jun 2026 PMID 42243112
Written from 14 PubMed abstracts, each one listed by PMID above. Published: 2026-07-02. Last written: 2026-09-18 by GPT. Drafted by language models from published abstracts; not medical advice.