Hyaluronic acid
Hyaluronic acid (HA) is a naturally occurring, high-molecular-weight polysaccharide and major component of the extracellular matrix (ECM) found throughout mammalian tissues.
Hyaluronic acid (HA) is a naturally occurring, high-molecular-weight polysaccharide and major component of the extracellular matrix (ECM) found throughout mammalian tissues. It is a linear glycosaminoglycan composed of repeating disaccharide units of glucuronic acid and N-acetylglucosamine. HA plays critical roles in tissue hydration, lubrication, and structural integrity, and serves as a ligand for cell surface receptors such as CD44, which mediate cellular interactions and inflammatory responses. Beyond its endogenous structural role, hyaluronic acid has emerged as a versatile bioactive scaffold in regenerative medicine, therapeutic delivery, and clinical treatment of degenerative diseases. Its biocompatibility, viscoelastic properties, and capacity to be chemically modified make it an attractive platform for injectable hydrogels, nanocomposites, and targeted pharmaceutical formulations.
Where the papers sit
17 papers from the last 6 months study hyaluronic acid directly · updated from PubMed 5 Oct 2026
Study type 2 clinical trials · 1 observational · 13 preclinical · 1 unclassified
Themes one subject · 1 new direction
Those 17 are all about one subject.
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Hyaluronan-Based Biomedical Materials
Injectable and cross-linked hyaluronan materials are being adapted for drug delivery, antimicrobial protection, tissue repair, ocular replacement, and joint treatment. Recurrent designs combine hyaluronan with collagen, chitosan, silk, scaffolds, nanoparticles, or thermoresponsive networks to tune mechanics and release. Reported endpoints range from wound closure, antibiofilm activity, and tendon-to-bone healing to ocular surface health, cardioprotection, graft preservation, and osteoarthritis symptoms. The cluster is application-driven, with efficacy, safety, durability, and translation still open across settings.
Dietary hyaluronan acts as a systemic microbiome–metabolism modulator
The healthy-murine dietary-hyaluronan study treats orally administered HA as a bioactive dietary polysaccharide rather than as a scaffold, topical agent, injection, biomaterial component, or drug-delivery vehicle 42314883Jun. It found that HA, unlike the comparator pectin, produced pronounced small-intestinal microbiome changes, enriched specific bacterial taxa, altered systemic metabolites and redox status, increased hydroxybutyrate-associated lipolysis, and differentially affected glycogen handling. This places HA in a new role as a possible gut–systemic metabolic modulator and opens a direction beyond the local structural and therapeutic functions represented by the other papers.
Papers
The 17 papers from the last 6 months that study hyaluronic acid directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Hyaluronan-Based Biomedical Materials (17)
- Short-term adjunctive use of a liposomal tear substitute after repeated intravitreal therapy: a randomized pilot study. International ophthalmology · 16 Sept 2026 PMID 42749868
- Mannose-functionalized thermoresponsive microneedles for enhanced antigen delivery and immune activation. Journal of materials chemistry. B · 27 Aug 2026 PMID 42657667
- Compounded 0.03% Tacrolimus in Cross-Linked Hyaluronate Improves Ocular Surface Health in Dogs With Evaporative Dry Eye Disease. Veterinary ophthalmology · 22 Aug 2026 PMID 42629626
- A Dual-Crosslinked Collagen/Hyaluronic Acid/Chitosan Hydrogel for Integrated Hemostasis and Infected Wound Healing. ACS biomaterials science & engineering · 19 Aug 2026 PMID 42615380
- Amyloid-Reinforced Hyaluronic Acid Composite Hydrogel Enabling Controlled Curcumin Delivery, Antibiofilm Photothermal Therapy, and Accelerated Diabetic Wound Healing. ACS applied materials & interfaces · 19 Aug 2026 PMID 42615159
- Hyaluronic Acid Electrostatically Grafted Quaternary Ammonium Salt: Preparation and Outstanding Antibacterial Performance. Biomacromolecules · 10 Aug 2026 PMID 42573344
- Normothermic Machine Perfusion Preserves Endothelial Clearance, Modulates Inflammation After Prolonged Warm Ischemia in Liver Grafts. Transplantation · 31 Jul 2026 PMID 42538579
- Engineering an injectable and tunable hydrogel as a potential vitreous substitute. Journal of materials chemistry. B · 14 Jul 2026 PMID 42446486
- Effectiveness and safety of intra-articular hyaluronic acid SEMICAL GEL-B CROSS therapy in knee osteoarthritis (SEM-ART1): Study protocol for a randomized, placebo controlled, double-blind, cross-over clinical trial. PloS one · 9 Jul 2026 PMID 42424346
- Dual-trigger hyaluronic acid nanoprodrug incorporating a 2-nitrobenzenesulfonyl linker for CD44-targeted and glutathione-responsive drug delivery. International journal of pharmaceutics · 4 Jul 2026 PMID 42401301
- Mesenchymal Stem Cell-Derived Exosomes Combined With 3-Dimensional Hyaluronan-Based Scaffold Promote Tendon-to-Bone Tunnel Healing. The Journal of hand surgery · 3 Jul 2026 PMID 42397317
- Interface engineering to enhance properties of bioprosthetic heart valve materials with polysaccharide nanocomposite-conjugated hydrogels. Acta biomaterialia · 1 Jul 2026 PMID 42386110
- Anomalous Diffusion of Nanoparticles in Semidilute Hyaluronic Acid Solutions. Biomacromolecules · 29 Jun 2026 PMID 42371946
- Hyaluronic acid and PEA-based Rutin-loaded nanoparticles as new cardioprotective tool against anthracycline-induced cardiotoxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 24 Jun 2026 PMID 42342159
- Silk nanoengineering for in situ forming injectable ECM-inspired hydrogels. Acta biomaterialia · 19 Jun 2026 PMID 42320704
- Hyaluronan exerts unique microbiome and metabolic effects compared with pectin: a multi-omics study of dietary polysaccharides. International journal of biological macromolecules · 18 Jun 2026 PMID 42314883
- Intra-Articular Purified Exosome Product and Hyaluronan Attenuate Osteoarthritis Progression in a Minimally Invasive Turkey Model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 29 Apr 2026 PMID 42051070
By study type
Clinical trials (2)
- Short-term adjunctive use of a liposomal tear substitute after repeated intravitreal therapy: a randomized pilot study. International ophthalmology · 16 Sept 2026 PMID 42749868
- Effectiveness and safety of intra-articular hyaluronic acid SEMICAL GEL-B CROSS therapy in knee osteoarthritis (SEM-ART1): Study protocol for a randomized, placebo controlled, double-blind, cross-over clinical trial. PloS one · 9 Jul 2026 PMID 42424346
Observational studies and case reports (1)
- Compounded 0.03% Tacrolimus in Cross-Linked Hyaluronate Improves Ocular Surface Health in Dogs With Evaporative Dry Eye Disease. Veterinary ophthalmology · 22 Aug 2026 PMID 42629626
Preclinical: animal, cell and lab studies (13)
- Mannose-functionalized thermoresponsive microneedles for enhanced antigen delivery and immune activation. Journal of materials chemistry. B · 27 Aug 2026 PMID 42657667
- A Dual-Crosslinked Collagen/Hyaluronic Acid/Chitosan Hydrogel for Integrated Hemostasis and Infected Wound Healing. ACS biomaterials science & engineering · 19 Aug 2026 PMID 42615380
- Amyloid-Reinforced Hyaluronic Acid Composite Hydrogel Enabling Controlled Curcumin Delivery, Antibiofilm Photothermal Therapy, and Accelerated Diabetic Wound Healing. ACS applied materials & interfaces · 19 Aug 2026 PMID 42615159
- Hyaluronic Acid Electrostatically Grafted Quaternary Ammonium Salt: Preparation and Outstanding Antibacterial Performance. Biomacromolecules · 10 Aug 2026 PMID 42573344
- Normothermic Machine Perfusion Preserves Endothelial Clearance, Modulates Inflammation After Prolonged Warm Ischemia in Liver Grafts. Transplantation · 31 Jul 2026 PMID 42538579
- Engineering an injectable and tunable hydrogel as a potential vitreous substitute. Journal of materials chemistry. B · 14 Jul 2026 PMID 42446486
- Dual-trigger hyaluronic acid nanoprodrug incorporating a 2-nitrobenzenesulfonyl linker for CD44-targeted and glutathione-responsive drug delivery. International journal of pharmaceutics · 4 Jul 2026 PMID 42401301
- Mesenchymal Stem Cell-Derived Exosomes Combined With 3-Dimensional Hyaluronan-Based Scaffold Promote Tendon-to-Bone Tunnel Healing. The Journal of hand surgery · 3 Jul 2026 PMID 42397317
- Interface engineering to enhance properties of bioprosthetic heart valve materials with polysaccharide nanocomposite-conjugated hydrogels. Acta biomaterialia · 1 Jul 2026 PMID 42386110
- Anomalous Diffusion of Nanoparticles in Semidilute Hyaluronic Acid Solutions. Biomacromolecules · 29 Jun 2026 PMID 42371946
- Hyaluronic acid and PEA-based Rutin-loaded nanoparticles as new cardioprotective tool against anthracycline-induced cardiotoxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 24 Jun 2026 PMID 42342159
- Silk nanoengineering for in situ forming injectable ECM-inspired hydrogels. Acta biomaterialia · 19 Jun 2026 PMID 42320704
- Intra-Articular Purified Exosome Product and Hyaluronan Attenuate Osteoarthritis Progression in a Minimally Invasive Turkey Model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 29 Apr 2026 PMID 42051070
Unclassified: not yet indexed with MeSH (1)
- Hyaluronan exerts unique microbiome and metabolic effects compared with pectin: a multi-omics study of dietary polysaccharides. International journal of biological macromolecules · 18 Jun 2026 PMID 42314883
Written from 17 PubMed abstracts, each one listed by PMID above. Published: 2026-08-02. Last written: 2026-09-18 by GPT. Drafted by language models from published abstracts; not medical advice.