Rutin
Rutin is a naturally occurring flavonoid glycoside, widely distributed in plants and commonly discussed in biomedical research for its antioxidant, anti-inflammatory, anti-angiogenic, and broader cytoprotective properties.
Rutin is a naturally occurring flavonoid glycoside, widely distributed in plants and commonly discussed in biomedical research for its antioxidant, anti-inflammatory, anti-angiogenic, and broader cytoprotective properties. It is frequently identified in botanical and food matrices such as Sophora japonica, Fagopyrum esculentum (buckwheat), Morus alba leaves, citrus cultivars, pitaya peels, and other polyphenol-rich materials. In recent studies, rutin has been considered both as a bioactive constituent of complex extracts and as a standalone compound with potential therapeutic relevance.
Biologically, rutin is often investigated in relation to oxidative stress, inflammatory signaling, and disease pathways involving nuclear factor kappa B (NF-κB), toll like receptor 4 (TLR4), RUNX1, and related mediators. Across the provided studies, it was associated with antioxidant defense, modulation of proinflammatory cytokines, protection of the intestinal barrier, effects on metabolic dysfunction–associated steatotic liver disease, and antiangiogenic activity. It is also being explored in formulation strategies, including PEG-β-cyclodextrin and other delivery systems, to improve its in vivo performance.
Where the papers sit
17 papers from the last 6 months study rutin directly · updated from PubMed 3 Oct 2026
Study type 0 clinical trials · 17 preclinical
Themes one subject · 1 paradigm shift
Those 17 are all about one subject.
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Rutin-Based Therapeutics
Rutin research is moving toward engineered delivery rather than unformulated administration, using hydrogels, nanoparticles, cerosomes and lipid carriers to improve local or systemic exposure. Reported aims include reducing inflammation, oxidative and anthracycline-induced cardiac injury, protecting barriers, repairing wounds and enhancing anticancer treatment. Pharmacodynamic, pharmacokinetic and network analyses are paired with animal and cell studies, but evidence remains preclinical and heterogeneous. No single mechanism or disease endpoint dominates beyond testing rutin as a multifunctional therapeutic.
Rutin is independently shown to act through direct protein targets rather than only through broad antioxidant and anti-inflammatory effects
The NAFLD model using high-fat-diet ApoE−/− mice and free-fatty-acid-exposed HepG2 cells and the glioblastoma model centered on the MET–YANK2 axis found instead that rutin directly binds RUNX1 and YANK2, respectively, disrupting disease-promoting molecular interactions and signaling; this replaces a general antioxidant/anti-inflammatory account with a target-specific mechanism in which rutin can directly interfere with pathogenic protein networks 41997405Apr 42337173Jun.
Papers
The 17 papers from the last 6 months that study rutin directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Rutin-Based Therapeutics (17)
- Generation of Probiotic-Based Multifunctional Hydrogels Capable of Carrying Oxygen and Anti-Inflammatory Drugs and Their Effect on Cell Viability Under Hypoxic Conditions. Journal of biomedical materials research. Part A · 28 Sept 2026 PMID 42803184
- HPRT1 drives mitochondrial metabolic reprogramming and immunosuppressive microenvironment in oral squamous cell carcinoma. Apoptosis : an international journal on programmed cell death · 25 Sept 2026 PMID 42791403
- Rutin loaded nanosponges for treatment of peptic ulcer: in silico, pharmacodynamic and pharmacokinetic studies. AAPS PharmSciTech · 15 Sept 2026 PMID 42736524
- Integrative Phytochemical, Antioxidant, and NLRP3-Linked and Anti-Inflammatory Evaluation of Salvia balansae (Aurès Chemotype): Insights Into Its Safety and Therapeutic Potential. ChemistryOpen · 21 Aug 2026 PMID 42625396
- Development of an injectable thermosensitive chitosan-based hydrogel for localized rutin delivery optimized using Box-Behnken design. Drug development and industrial pharmacy · 12 Aug 2026 PMID 42583906
- Therapeutic Potential of Solanum macrocarpon in Uterine Leiomyoma: In Vivo and In Silico Approaches. FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 5 Aug 2026 PMID 42555862
- Ultrasound-assisted pH-shifting for structuring rutin-loaded zein-soy protein isolate-inulin nanoparticles: Structural reorganization, interfacial stabilization, and gastrointestinal delivery. Ultrasonics sonochemistry · 4 Aug 2026 PMID 42551122
- Rutin-enabled improved systemic exposure of doxorubicin via nanostructured lipid carriers: a proof of concept through novel LC-MS/MS analysis. Drug development and industrial pharmacy · 11 Jul 2026 PMID 42435317
- Nanocomplex-Integrated Multifunctional Hydrogel for Fast-Tracked Wound Repair Application: A Preclinical Evaluation. ACS applied bio materials · 30 Jun 2026 PMID 42377005
- Hyaluronic acid and PEA-based Rutin-loaded nanoparticles as new cardioprotective tool against anthracycline-induced cardiotoxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 24 Jun 2026 PMID 42342159
- MET-mediated phosphorylation of YANK2 at Y282 inhibits NEDD4L-dependent SUMOylation and degradation, promoting chemoresistance in glioblastoma. Molecular biomedicine · 23 Jun 2026 PMID 42337173
- Glucosamine/chitosan blend surface-engineered rutin-loaded polymer/lipid hybrid nanoparticles for neuroprotection in induced schizophrenia model. Scientific reports · 17 Jun 2026 PMID 42310329
- Development of rutin-loaded cerosomes for topical photoprotection and skin barrier modulation. International journal of pharmaceutics · 15 Jun 2026 PMID 42297314
- Integrated UPLC-QTOF-MS and Network Pharmacology for Predicting Active Constituents and Pharmacological Mechanisms of Yinxingye Tablets Against Oxidative Stress. Biomedical chromatography : BMC · 9 May 2026 PMID 42104588
- Therapeutic effect of rutin on Henoch-Schönlein purpura by attenuating inflammation and protection of the intestinal barrier function in rats. European journal of pharmacology · 8 May 2026 PMID 42103052
- Nisin and rutin as potential coating agents for iron oxide nanoparticles for enhanced theranostic applications against cancer. Scientific reports · 1 May 2026 PMID 42067522
- Multi-omics reveals rutin directly targets RUNX1 to disrupt the RUNX1/TET2 complex and alleviate NAFLD via TLR4/NF-κB inhibition. European journal of pharmacology · 17 Apr 2026 PMID 41997405
By study type
Preclinical: animal, cell and lab studies (17)
- Generation of Probiotic-Based Multifunctional Hydrogels Capable of Carrying Oxygen and Anti-Inflammatory Drugs and Their Effect on Cell Viability Under Hypoxic Conditions. Journal of biomedical materials research. Part A · 28 Sept 2026 PMID 42803184
- HPRT1 drives mitochondrial metabolic reprogramming and immunosuppressive microenvironment in oral squamous cell carcinoma. Apoptosis : an international journal on programmed cell death · 25 Sept 2026 PMID 42791403
- Rutin loaded nanosponges for treatment of peptic ulcer: in silico, pharmacodynamic and pharmacokinetic studies. AAPS PharmSciTech · 15 Sept 2026 PMID 42736524
- Integrative Phytochemical, Antioxidant, and NLRP3-Linked and Anti-Inflammatory Evaluation of Salvia balansae (Aurès Chemotype): Insights Into Its Safety and Therapeutic Potential. ChemistryOpen · 21 Aug 2026 PMID 42625396
- Development of an injectable thermosensitive chitosan-based hydrogel for localized rutin delivery optimized using Box-Behnken design. Drug development and industrial pharmacy · 12 Aug 2026 PMID 42583906
- Therapeutic Potential of Solanum macrocarpon in Uterine Leiomyoma: In Vivo and In Silico Approaches. FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 5 Aug 2026 PMID 42555862
- Ultrasound-assisted pH-shifting for structuring rutin-loaded zein-soy protein isolate-inulin nanoparticles: Structural reorganization, interfacial stabilization, and gastrointestinal delivery. Ultrasonics sonochemistry · 4 Aug 2026 PMID 42551122
- Rutin-enabled improved systemic exposure of doxorubicin via nanostructured lipid carriers: a proof of concept through novel LC-MS/MS analysis. Drug development and industrial pharmacy · 11 Jul 2026 PMID 42435317
- Nanocomplex-Integrated Multifunctional Hydrogel for Fast-Tracked Wound Repair Application: A Preclinical Evaluation. ACS applied bio materials · 30 Jun 2026 PMID 42377005
- Hyaluronic acid and PEA-based Rutin-loaded nanoparticles as new cardioprotective tool against anthracycline-induced cardiotoxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 24 Jun 2026 PMID 42342159
- MET-mediated phosphorylation of YANK2 at Y282 inhibits NEDD4L-dependent SUMOylation and degradation, promoting chemoresistance in glioblastoma. Molecular biomedicine · 23 Jun 2026 PMID 42337173
- Glucosamine/chitosan blend surface-engineered rutin-loaded polymer/lipid hybrid nanoparticles for neuroprotection in induced schizophrenia model. Scientific reports · 17 Jun 2026 PMID 42310329
- Development of rutin-loaded cerosomes for topical photoprotection and skin barrier modulation. International journal of pharmaceutics · 15 Jun 2026 PMID 42297314
- Integrated UPLC-QTOF-MS and Network Pharmacology for Predicting Active Constituents and Pharmacological Mechanisms of Yinxingye Tablets Against Oxidative Stress. Biomedical chromatography : BMC · 9 May 2026 PMID 42104588
- Therapeutic effect of rutin on Henoch-Schönlein purpura by attenuating inflammation and protection of the intestinal barrier function in rats. European journal of pharmacology · 8 May 2026 PMID 42103052
- Nisin and rutin as potential coating agents for iron oxide nanoparticles for enhanced theranostic applications against cancer. Scientific reports · 1 May 2026 PMID 42067522
- Multi-omics reveals rutin directly targets RUNX1 to disrupt the RUNX1/TET2 complex and alleviate NAFLD via TLR4/NF-κB inhibition. European journal of pharmacology · 17 Apr 2026 PMID 41997405
Written from 17 PubMed abstracts, each one listed by PMID above. Published: 2026-06-16. Last written: 2026-09-17 by GPT. Drafted by language models from published abstracts; not medical advice.