Staphylococcus aureus

Where the papers sit

66 papers from the last 6 months study staphylococcus aureus directly · updated from PubMed 12 Oct 2026

• Broad-Spectrum Antimicrobial Discovery

  New antibacterial candidates are being drawn from plant extracts, marine diterpenoids, engineered peptides, tetramate scaffolds, and biosynthesized metal nanoparticles. Studies repeatedly measure minimum inhibitory concentrations, bactericidal activity, cytotoxicity, and activity against methicillin-resistant Staphylococcus aureus alongside Escherichia coli and Pseudomonas aeruginosa. Chemical diversification, genome mining, molecular design, and ROS-responsive materials are widening the candidate space. Selectivity, biocompatibility, and in vivo efficacy remain less established than in vitro potency.

  16 papers · 24.2%

• Infected Wound Healing

  Infected wound care is moving toward multifunctional biomaterials that combine antibacterial action with hemostasis, antioxidant activity, immune modulation, and tissue regeneration. Chitosan hydrogels, cryogels, films, microneedles, and adhesive patches recur as platforms for controlled antibiotic or nanoparticle delivery. Photothermal systems, silver nanoparticles, desferrioxamine, and personalized bioprinting target biofilms, diabetic ulcers, and impaired vascular repair. Collagen deposition, neovascularization, and closure are increasingly assessed alongside microbial reduction, but clinical translation remains open.

  15 papers · 22.7%

• Rapid Bacterial Detection

  Rapid detection of Staphylococcus aureus and other pathogens is shifting toward integrated CRISPR/Cas12a, rolling-circle amplification, DNAzyme, fluorescence, chemiluminescence, and microfluidic platforms. Several systems target methicillin-resistant Staphylococcus aureus or multiple foodborne bacteria while emphasizing low detection limits and minimal equipment. Spectroscopy with explainable machine learning adds species discrimination without culture. The dominant direction is faster multiplex and point-of-care testing, although wound-treatment and environmental-monitoring studies sit outside the main diagnostic focus.

  11 papers · 16.7%

• Antibiofilm Drug Discovery

  Biofilm treatment is moving beyond conventional antibiotics toward enzyme-powered micromotors, photodynamic inactivation, essential oils, plant metabolites, and engineered nanocarriers. Recurrent endpoints include biofilm viability, biomass, metabolic activity, membrane integrity, and regrowth after treatment. Nanoemulsification and liposomal delivery are used to improve activity against multidrug-resistant Staphylococcus aureus and other pathogens. Translation still depends on proving that these agents retain potency in complex clinical biofilms.

  9 papers · 13.6%

• Natural Product Antimicrobial Delivery

  Natural oils, extracts, and microbial metabolites are being converted into more usable antimicrobial formulations through nanoemulsions, cyclodextrin complexes, liposomal systems, hydrogels, and coated nanovesicles. Encapsulation and controlled release recur as strategies to improve solubility, stability, targeting, and antibacterial activity. Chemical profiling and molecular docking are used to connect composition with activity against Staphylococcus aureus and other pathogens. The work is progressing toward multifunctional products that combine antimicrobial, anti-inflammatory, antioxidant, and tissue-compatible effects.

  8 papers · 12.1%

• Reactive Oxygen Wound Therapy

  Reactive oxygen species are being harnessed to treat infected skin and oral wounds while supporting tissue repair. Plasma-activated hydrogels, photodynamic and sonodynamic systems, and visible-light carbon dots target biofilms through hydrogen peroxide or related oxidants. Self-healing sealants and microneedle delivery add adhesion, antioxidant control, and sustained local treatment. The main open issue is balancing bacterial killing with oxidative tissue injury and durable wound healing.

  7 papers · 10.6%