Candida albicans
Candida albicans is a polymorphic yeast and opportunistic fungal pathogen that is part of the normal human microbiota but can cause disease when host defenses are impaired or local ecological conditions change.
Candida albicans is a polymorphic yeast and opportunistic fungal pathogen that is part of the normal human microbiota but can cause disease when host defenses are impaired or local ecological conditions change. It is a major cause of mucosal candidiasis, including oropharyngeal candidiasis, and can also produce invasive fungal infections in immunocompromised individuals. A key feature of its pathogenicity is its ability to form biofilms and to adapt to host niches, including hypoxic microenvironments, which can contribute to persistence and treatment difficulty.
In biomedical research, C. albicans is frequently used as a target organism for antifungal discovery, biomaterials testing, and host–pathogen interaction studies. Recent work has focused on its susceptibility to natural products, nanoparticles, polymer-based delivery systems, and azole-class antifungals, as well as on immune-recognition pathways involving beta-glucan sensing and lectin receptors such as C-type lectin domain containing 6A and C-type lectin domain containing 7A.
Where the papers sit
9 papers from the last 6 months study candida albicans directly · updated from PubMed 10 Oct 2026
Study type 0 clinical trials · 3 human data · 6 preclinical
Themes one subject
Those 9 are all about one subject.
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Antifungal Strategies
Antifungal strategies range from genetic tools and efflux-pump inhibition to natural products, nanoparticles, and modified dental materials. Recurrent goals are overcoming drug resistance, suppressing biofilms, and improving activity against Candida in denture stomatitis and other settings. Miconazole, Hst 5 derivatives, selenium, silver, and chlorinated flavones illustrate the breadth of candidate approaches. The field remains exploratory, with no single therapeutic direction or shared lead emerging.
Papers
The 9 papers from the last 6 months that study candida albicans directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Antifungal Strategies (9)
- Expansion and optimization of the auxin-inducible degron 2 (AID2) system in Candida pathogens. mSphere · 21 Aug 2026 PMID 42627152
- Fabrication of an Antifungal PMMA Denture Nanocomposite Functionalized with Miconazole-Pectin-Silver Nanoparticles against Denture Stomatitis. ACS applied bio materials · 27 Jul 2026 PMID 42504423
- Computer-Aided Rational Modification of Hst 5 Based on Ssa1/2 and the Antifungal Activity of the Derivatives against Candida spp. Journal of medicinal chemistry · 22 Jun 2026 PMID 42332364
- Synthesis of Novel Isoxazoline Derivatives with Selective Inhibition of the Drug Efflux Pump Mdr1 to Reverse Drug Resistance of Candida albicans In Vitro and In Vivo. Journal of medicinal chemistry · 17 Jun 2026 PMID 42304548
- Chemical Composition and Antifungal Evaluation of Essential Oil From Fresh Leaves of Myrcia spectabilis DC Against Candida spp. and Pichia kudriavzevii. Chemistry & biodiversity · 30 May 2026 PMID 42216857
- Facile green synthesis of selenium nanoparticles using olive (Olea europaea) leaf extract and their antimicrobial and antibiofilm properties. Scientific reports · 16 May 2026 PMID 42143081
- Antimicrobial DMAHDM nanoparticle-modified resin for 3D printing: Composition-Property relationships. Journal of the mechanical behavior of biomedical materials · 12 May 2026 PMID 42119320
- Discovery and evaluation of a marine-derived chlorinated flavone derivative CHNQD-02204 as a potent and selective antifungal agent against Candida albicans. European journal of medicinal chemistry · 1 May 2026 PMID 42066379
- Phytochemical profiling and in vitro biological activities of Opuntia ficus-indica oil extracted by different methods. Scientific reports · 29 Apr 2026 PMID 42056158
By study type
Human data, design not indexed (3)
- Fabrication of an Antifungal PMMA Denture Nanocomposite Functionalized with Miconazole-Pectin-Silver Nanoparticles against Denture Stomatitis. ACS applied bio materials · 27 Jul 2026 PMID 42504423
- Computer-Aided Rational Modification of Hst 5 Based on Ssa1/2 and the Antifungal Activity of the Derivatives against Candida spp. Journal of medicinal chemistry · 22 Jun 2026 PMID 42332364
- Antimicrobial DMAHDM nanoparticle-modified resin for 3D printing: Composition-Property relationships. Journal of the mechanical behavior of biomedical materials · 12 May 2026 PMID 42119320
Preclinical: animal, cell and lab studies (6)
- Expansion and optimization of the auxin-inducible degron 2 (AID2) system in Candida pathogens. mSphere · 21 Aug 2026 PMID 42627152
- Synthesis of Novel Isoxazoline Derivatives with Selective Inhibition of the Drug Efflux Pump Mdr1 to Reverse Drug Resistance of Candida albicans In Vitro and In Vivo. Journal of medicinal chemistry · 17 Jun 2026 PMID 42304548
- Chemical Composition and Antifungal Evaluation of Essential Oil From Fresh Leaves of Myrcia spectabilis DC Against Candida spp. and Pichia kudriavzevii. Chemistry & biodiversity · 30 May 2026 PMID 42216857
- Facile green synthesis of selenium nanoparticles using olive (Olea europaea) leaf extract and their antimicrobial and antibiofilm properties. Scientific reports · 16 May 2026 PMID 42143081
- Discovery and evaluation of a marine-derived chlorinated flavone derivative CHNQD-02204 as a potent and selective antifungal agent against Candida albicans. European journal of medicinal chemistry · 1 May 2026 PMID 42066379
- Phytochemical profiling and in vitro biological activities of Opuntia ficus-indica oil extracted by different methods. Scientific reports · 29 Apr 2026 PMID 42056158
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-07-01. Last written: 2026-08-26 by GPT. Drafted by language models from published abstracts; not medical advice.