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Depression

Depression is a common psychiatric disease characterized by persistent depressive mood and/or loss of interest or pleasure, accompanied by cognitive, emotional, behavioral, and physical symptoms.

Where the papers sit

17 papers from the last 6 months study depression directly · updated from PubMed 3 Nov 2026

  • Depression Across Medical Conditions

    Depression and anxiety are being mapped across asthma, diabetes, cancer, nasopharyngeal disease, and general adult populations. PHQ-9 and GAD-7 recur alongside insomnia, body mass index, symptom burden, and cognitive function. Observational work links depression with systemic inflammation and gallstones, while digital agents and mental health apps test scalable support. The evidence remains largely cross-sectional or feasibility-based, leaving causal pathways and clinical effectiveness open.

    9 papers · 52.9%

  • Nonpharmacologic Mental Health Care

    Exercise, yoga, behavioural activation, laughter-based interventions, acupuncture, and digital therapeutics are being tested as adjuncts for depression, anxiety, and distress in chronic illness. Studies emphasize feasibility, acceptability, usual-care integration, work ability, and cost-effectiveness across rheumatoid arthritis, dialysis, autism, chronic pain, diabetes, and other conditions. Randomized trials provide some support for yoga-based approaches, while several interventions remain at protocol or provider-attitude stages. The direction is toward accessible multimodal care, but comparative effectiveness and durability remain uncertain.

    6 papers · 35.3%

  • AI Mental Health Representation

    AI is being developed both to simulate clinical encounters and to represent depression in generated media. Voice-enabled virtual patients focus on standardized assessment, language, training, and interrater reliability. Generative video work instead examines how models depict depression and whether those portrayals are clinically credible. Together, the field is moving toward evaluating realism, bias, and educational usefulness rather than treating AI output as inherently reliable.

    2 papers · 11.8%

NEW DIRECTION

Depression becomes an object of generative-AI representation rather than a clinical symptom, comorbidity, outcome, or treatment target

The study of OpenAI’s Sora 2 examines how a generative video model depicts “depression” across consumer-app and developer-API access points, rather than measuring depression in patients or treating it as a clinical state. It finds that the model’s visual narratives and computational features can be characterized and compared according to the product layer mediating generation. This extends the set into the study of depression as an AI-produced cultural and visual representation, with attention to how model interfaces shape its portrayal 42735385Sep.

Papers

The 17 papers from the last 6 months that study depression directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.

By theme

Depression Across Medical Conditions (9)
  1. Pathologies and technologies for digital therapeutics: An analysis of global clinical trials. PLOS digital health · 14 Oct 2026 PMID 42873745
  2. Trends in Depression and Its Association With Gallstones: Evidence From NHANES With Exploration of Mediating Pathways. Depression and anxiety · 23 Sept 2026 PMID 42775219
  3. Beta Testing an mHealth Symptom Management Intervention for People With Advanced Cancer: Single-Cohort Feasibility and Acceptability Study. JMIR cancer · 16 Sept 2026 PMID 42748353
  4. Clinically relevant depression in patients with type 1 and type 2 diabetes; a nationwide study (TEMD-2 depression). Endocrine · 9 Sept 2026 PMID 42714690
  5. Association between systemic inflammation response index and depression in U.S. adults: A cross-sectional study from NHANES 2005-2016. Medicine · 22 Aug 2026 PMID 42629730
  6. Prevalence of anxiety and depression among in-patient and out-patient asthmatic patients in Jordan: A cross-sectional study. Medicine · 15 Aug 2026 PMID 42601735
  7. Effectiveness and Cost-Effectiveness of the Tankevirus and Grubl Mental Health Apps Compared With a Placebo App-Mental Health Intervention With Digital Applications (MIND-APP): Protocol for a Randomized Controlled Researcher-Blinded Trial. JMIR research protocols · 10 Aug 2026 PMID 42575499
  8. Patterns of Engagement With an AI Conversational Agent for Mental Health and Associations With Anxiety and Depression: Cross-Sectional Study. JMIR mental health · 10 Aug 2026 PMID 42574544
  9. The chain-mediating role of anxiety and depression in the relationship between symptom clusters and perceived cognitive function in nasopharyngeal carcinoma survivors: a cross-sectional study of 556 participants. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 29 Jul 2026 PMID 42527676
Nonpharmacologic Mental Health Care (6)
  1. Effectiveness and cost-effectiveness of the Pain-at-Work Toolkit for improving work ability in adults with chronic pain: protocol for a cluster randomised controlled trial. BMJ open · 9 Sept 2026 PMID 42716686
  2. Effectiveness of Yoga and Combined Exercise in Female With Rheumatoid Arthritis: Randomized Controlled Trial. Musculoskeletal care · 28 Aug 2026 PMID 42661382
  3. A feasibility study of behavioural activation for haemodialysis: The BEACH study protocol. PloS one · 6 Aug 2026 PMID 42560999
  4. Effects of laughter yoga on reducing depression and anxiety in children with autism spectrum disorder and parenting stress in their parents: study protocol for a randomised-controlled feasibility trial. BMJ open · 16 Jun 2026 PMID 42303395
  5. Exploring provider attitudes towards digital therapeutics for diabetes and depression. Scientific reports · 4 Jun 2026 PMID 42243321
  6. Clinical outcomes of acupuncture combined with Jieyu Huoxue Formula in optic atrophy: effects on hemorheology and retrobulbar blood flow. Brain research · 11 May 2026 PMID 42114798
AI Mental Health Representation (2)
  1. Voice-Enabled Virtual Patients for Interactive Training in Standardized Clinical Assessment: Mixed Methods Pilot Study. Journal of medical Internet research · 2 Oct 2026 PMID 42826247
  2. Depictions of Depression in Generative AI Video Models: Mixed Methods Study of OpenAI's Sora 2. Journal of medical Internet research · 14 Sept 2026 PMID 42735385

By study type

Clinical trials (6)
  1. Effectiveness and cost-effectiveness of the Pain-at-Work Toolkit for improving work ability in adults with chronic pain: protocol for a cluster randomised controlled trial. BMJ open · 9 Sept 2026 PMID 42716686
  2. Effectiveness of Yoga and Combined Exercise in Female With Rheumatoid Arthritis: Randomized Controlled Trial. Musculoskeletal care · 28 Aug 2026 PMID 42661382
  3. Effectiveness and Cost-Effectiveness of the Tankevirus and Grubl Mental Health Apps Compared With a Placebo App-Mental Health Intervention With Digital Applications (MIND-APP): Protocol for a Randomized Controlled Researcher-Blinded Trial. JMIR research protocols · 10 Aug 2026 PMID 42575499
  4. A feasibility study of behavioural activation for haemodialysis: The BEACH study protocol. PloS one · 6 Aug 2026 PMID 42560999
  5. Effects of laughter yoga on reducing depression and anxiety in children with autism spectrum disorder and parenting stress in their parents: study protocol for a randomised-controlled feasibility trial. BMJ open · 16 Jun 2026 PMID 42303395
  6. Clinical outcomes of acupuncture combined with Jieyu Huoxue Formula in optic atrophy: effects on hemorheology and retrobulbar blood flow. Brain research · 11 May 2026 PMID 42114798
Observational studies and case reports (6)
  1. Beta Testing an mHealth Symptom Management Intervention for People With Advanced Cancer: Single-Cohort Feasibility and Acceptability Study. JMIR cancer · 16 Sept 2026 PMID 42748353
  2. Clinically relevant depression in patients with type 1 and type 2 diabetes; a nationwide study (TEMD-2 depression). Endocrine · 9 Sept 2026 PMID 42714690
  3. Association between systemic inflammation response index and depression in U.S. adults: A cross-sectional study from NHANES 2005-2016. Medicine · 22 Aug 2026 PMID 42629730
  4. Prevalence of anxiety and depression among in-patient and out-patient asthmatic patients in Jordan: A cross-sectional study. Medicine · 15 Aug 2026 PMID 42601735
  5. Patterns of Engagement With an AI Conversational Agent for Mental Health and Associations With Anxiety and Depression: Cross-Sectional Study. JMIR mental health · 10 Aug 2026 PMID 42574544
  6. The chain-mediating role of anxiety and depression in the relationship between symptom clusters and perceived cognitive function in nasopharyngeal carcinoma survivors: a cross-sectional study of 556 participants. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 29 Jul 2026 PMID 42527676
Human data, design not indexed (3)
  1. Voice-Enabled Virtual Patients for Interactive Training in Standardized Clinical Assessment: Mixed Methods Pilot Study. Journal of medical Internet research · 2 Oct 2026 PMID 42826247
  2. Trends in Depression and Its Association With Gallstones: Evidence From NHANES With Exploration of Mediating Pathways. Depression and anxiety · 23 Sept 2026 PMID 42775219
  3. Depictions of Depression in Generative AI Video Models: Mixed Methods Study of OpenAI's Sora 2. Journal of medical Internet research · 14 Sept 2026 PMID 42735385
Unclassified: not yet indexed with MeSH (2)
  1. Pathologies and technologies for digital therapeutics: An analysis of global clinical trials. PLOS digital health · 14 Oct 2026 PMID 42873745
  2. Exploring provider attitudes towards digital therapeutics for diabetes and depression. Scientific reports · 4 Jun 2026 PMID 42243321