Tnf
Tnf is a gene encoding tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine involved in regulation of the inflammatory response.
Tnf is a gene encoding tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine involved in regulation of the inflammatory response. TNF-α is studied in association with other mediators, including interleukin-6 (IL-6), CCL2 and interleukin-1β (IL-1β), and with signaling networks such as NF-κB, MAPK and PI3K–AKT. Recent work has examined TNF-α in neuroinflammation, airway inflammation mediated by ILC2s, spinal cord injury, skin inflammation and age-related systemic inflammation. In aging mice, circulating TNF-α has been associated with blood-based epigenetic age and targeted CpG methylation signatures.
Tnf is also an experimental therapeutic target. Small interfering RNA directed against TNF-α has been incorporated into lipid nanoparticles, hybrid lipid–polymeric nanoparticles and dissolving microneedles, including formulations combined with coenzyme Q10 or dexamethasone for localized skin treatment of psoriasis and other inflammatory conditions. Botanical and compound-based interventions have likewise been investigated through network pharmacology and pathway analyses that nominate TNF alongside targets such as MMP9, PTGS2, SRC and AKT1. These applications remain principally preclinical and focus on reducing cytokine-driven inflammation and downstream inflammatory signaling.
Where the papers sit
9 papers from the last 6 months study tnf directly · updated from PubMed 2 Nov 2026
Study type 0 clinical trials · 1 observational · 7 preclinical · 1 unclassified
Themes 3 themes
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Botanical Anti-Inflammatory Therapies
Natural products are being paired with mechanism-guided analysis to identify anti-inflammatory therapies. Network pharmacology and molecular docking repeatedly nominate compounds such as ginsenoside Rg1, methylophiopogonanone B, Ciwujia constituents and Panax notoginseng components. Experimental validation commonly uses Western blotting and inflammatory-pathway readouts. Applications range from neuroinflammation and anxiety-like behavior to wound healing and metal-associated spinal injury, leaving efficacy across conditions unresolved.
5 papers · 55.6%
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Cytokine-Driven Inflammation
Cytokine signaling links systemic aging inflammation with airway disease. In mice, circulating TNF-α, CCL2 and IL-6 track epigenetic age and targeted CpG methylation signatures. Asthma work instead emphasizes arginine metabolism and NF-ĸB control of ILC2-mediated airway inflammation. These preclinical findings define inflammatory biomarkers and pathways, but do not yet establish a shared therapeutic strategy.
2 papers · 22.2%
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siTNF-α Delivery for Psoriasis
Local siTNF-α delivery is being developed as a more targeted approach to psoriasis inflammation. Lipid or hybrid lipid-polymeric nanoparticles carry siTNF-α with coenzyme Q10 or dexamethasone for combined gene silencing and anti-inflammatory action. Dissolving microneedles aim to improve skin deposition while limiting systemic exposure. The work remains preclinical, with therapeutic durability, delivery efficiency and comparative benefit over established TNF blockade still open.
2 papers · 22.2%
Papers
The 9 papers from the last 6 months that study tnf directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Botanical Anti-Inflammatory Therapies (5)
- Compound Ciwujia Granules Attenuate Stress-Induced Anxiety- and Depression-Like Behaviors via Inhibition of TNF-α-Associated Neuroinflammation in the dmPFC. CNS neuroscience & therapeutics · 1 Oct 2026 PMID 42817052
- An Integrated Strategy for Decoding Bioactive Components and Mechanism of Jingtong Granules: Chemical Characterization, Network Analysis, Pharmacokinetic and Pharmacodynamic Studies. Biomedical chromatography : BMC · 17 Sept 2026 PMID 42750651
- Metallotoxicity-driven oxidative perturbations in spinal cord injury: Unraveling the pathophysiological nexus between metal-induced redox imbalance and disease severity: A correlational and multivariate analysis. Molecular biology reports · 15 Sept 2026 PMID 42742870
- Exploring the mechanism of Panax notoginseng injection in the treatment of skin wound based on network pharmacology and experimental verification. Journal of molecular histology · 4 Sept 2026 PMID 42696214
- Integrated GNPS Molecular Networking and Network Pharmacology Uncover Methylophiopogonanone B as a Novel Anti-Inflammatory Agent From Polygonatum cyrtonema Hua Targeting the SRC-PI3K-Akt Pathway. Biomedical chromatography : BMC · 22 Jul 2026 PMID 42484235
Cytokine-Driven Inflammation (2)
- Circulating TNF-α, CCL2 and IL-6 are associated with blood-based epigenetic age and targeted CpG methylation signatures in aging mice. Experimental gerontology · 6 Oct 2026 PMID 42838293
- Arginine metabolism and the NF-ĸB pathway jointly regulate the airway inflammation in asthma mediated by ILC2s. International immunopharmacology · 10 Jun 2026 PMID 42269551
siTNF-α Delivery for Psoriasis (2)
- Dissolving Microneedles Loaded with Lipid Nanoparticles for Co-Delivery of siTNF-α and Dexamethasone as a Dual-Action Therapy for Psoriasis. ACS applied materials & interfaces · 14 Sept 2026 PMID 42735507
- A dual functional hybrid lipid-polymeric nanoparticle co-loaded coenzyme Q10 and siRNA TNFα for anti-inflammatory skin therapy. International journal of pharmaceutics · 4 Sept 2026 PMID 42697387
By study type
Observational studies and case reports (1)
- Metallotoxicity-driven oxidative perturbations in spinal cord injury: Unraveling the pathophysiological nexus between metal-induced redox imbalance and disease severity: A correlational and multivariate analysis. Molecular biology reports · 15 Sept 2026 PMID 42742870
Preclinical: animal, cell and lab studies (7)
- Circulating TNF-α, CCL2 and IL-6 are associated with blood-based epigenetic age and targeted CpG methylation signatures in aging mice. Experimental gerontology · 6 Oct 2026 PMID 42838293
- Compound Ciwujia Granules Attenuate Stress-Induced Anxiety- and Depression-Like Behaviors via Inhibition of TNF-α-Associated Neuroinflammation in the dmPFC. CNS neuroscience & therapeutics · 1 Oct 2026 PMID 42817052
- An Integrated Strategy for Decoding Bioactive Components and Mechanism of Jingtong Granules: Chemical Characterization, Network Analysis, Pharmacokinetic and Pharmacodynamic Studies. Biomedical chromatography : BMC · 17 Sept 2026 PMID 42750651
- A dual functional hybrid lipid-polymeric nanoparticle co-loaded coenzyme Q10 and siRNA TNFα for anti-inflammatory skin therapy. International journal of pharmaceutics · 4 Sept 2026 PMID 42697387
- Exploring the mechanism of Panax notoginseng injection in the treatment of skin wound based on network pharmacology and experimental verification. Journal of molecular histology · 4 Sept 2026 PMID 42696214
- Integrated GNPS Molecular Networking and Network Pharmacology Uncover Methylophiopogonanone B as a Novel Anti-Inflammatory Agent From Polygonatum cyrtonema Hua Targeting the SRC-PI3K-Akt Pathway. Biomedical chromatography : BMC · 22 Jul 2026 PMID 42484235
- Arginine metabolism and the NF-ĸB pathway jointly regulate the airway inflammation in asthma mediated by ILC2s. International immunopharmacology · 10 Jun 2026 PMID 42269551
Unclassified: not yet indexed with MeSH (1)
- Dissolving Microneedles Loaded with Lipid Nanoparticles for Co-Delivery of siTNF-α and Dexamethasone as a Dual-Action Therapy for Psoriasis. ACS applied materials & interfaces · 14 Sept 2026 PMID 42735507
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-11-02. Drafted by language models from published abstracts; not medical advice.