Anxiety
Anxiety is a common psychiatric symptom and disorder category characterized by excessive fear, apprehension, hyperarousal, and related cognitive and somatic symptoms.
Anxiety is a common psychiatric symptom and disorder category characterized by excessive fear, apprehension, hyperarousal, and related cognitive and somatic symptoms. Clinically, it may occur as a primary disorder or as a comorbid feature across many medical and psychiatric conditions, including depression, chronic pain syndromes, Parkinson's disease, endometriosis, systemic lupus erythematosus, fibromyalgia, cancer-related caregiving stress, and metabolic or endocrine disorders. Because anxiety can influence quality of life, treatment adherence, symptom burden, and functional outcomes, it is frequently measured as both a clinical endpoint and a covariate in biomedical research.
Biologically, anxiety is linked to dysregulation across multiple systems, including brain-gut signaling, stress-response pathways, neuroendocrine function, and neural circuits involved in emotion processing and autonomic regulation. Recent studies in the provided corpus also connect anxiety with molecular and systems-level mechanisms such as MAPK/ERK/JNK signaling, mitophagy via the SIRT3/PINK1/Parkin pathway, oxytocin deficiency, and broader neuropsychiatric toxicity profiles of anticancer therapies. In this context, anxiety is not only a clinical diagnosis but also a measurable phenotype used to evaluate disease burden, treatment effects, and mechanistic hypotheses.
Where the papers sit
23 papers from the last 6 months study anxiety directly · updated from PubMed 1 Oct 2026
Study type 9 clinical trials · 9 observational · 4 human data · 1 preclinical
Themes 4 themes
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Anxiety and Depression Care
Anxiety and depression are being moved toward routine measurement and scalable support across medical and community settings. PHQ and GAD-7 scores anchor prevalence and symptom assessment, while AI conversational agents, mental-health apps, and EHR models test digital detection or intervention. Clinical studies add symptom mediation, perioperative anxiety reduction, stigma prediction, and a mechanistic herbal treatment, so endpoints remain diverse. Validation, engagement, and effectiveness across conditions remain unresolved.
8 papers · 34.8%
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Resilience in Psychological Distress
Psychological resilience and social support are emerging as modifiable buffers against anxiety and depression in caregivers and colorectal cancer patients. Rumination, maladaptive coping, attention to threat, insomnia, and sensory complaints recur as candidate pathways or clinical burdens. Parkinson's disease and frozen shoulder work broadens the question to non-pharmacological rehabilitation, while tinnitus studies emphasize assessment. The field remains focused on identifying protective factors and matching behavioral support to comorbidity rather than a single treatment.
5 papers · 21.7%
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Behavioral Mental Health Support
Yoga and laughter-based programs are being tested as low-burden ways to reduce anxiety, depression, and stress while supporting quality of life. Early work emphasizes feasibility and adjunctive use, including heart rate and heart rate variability in police officers and medication adherence in people with HIV. Autism-focused delivery also targets parenting stress, whereas youth work examines trust in risk prediction and preventive tools. Evidence remains preliminary and heterogeneous, with acceptability and physiological response still open.
3 papers · 13%
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Others — Symptoms and Quality of Life
Sleep, pain, mobility, and emotional symptoms are repeatedly linked to quality of life across cancer, dialysis, HIV, fibromyalgia, and chronic pain settings. Interventions range from medicinal cannabis and aromatherapy to virtual reality, while wearables and EEG seek objective markers of risk or symptom burden. Outcomes remain context-specific, spanning readmission, mortality, sleep, mood, and work ability rather than one shared endpoint. The cluster is therefore unified by patient-reported burden and function, not a single disease or treatment strategy.
7 papers · 30.4%
Papers
The 23 papers from the last 6 months that study anxiety directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Anxiety and Depression Care (8)
- Prevalence of anxiety and depression among in-patient and out-patient asthmatic patients in Jordan: A cross-sectional study. Medicine · 15 Aug 2026 PMID 42601735
- Effectiveness and Cost-Effectiveness of the Tankevirus and Grubl Mental Health Apps Compared With a Placebo App-Mental Health Intervention With Digital Applications (MIND-APP): Protocol for a Randomized Controlled Researcher-Blinded Trial. JMIR research protocols · 10 Aug 2026 PMID 42575499
- Patterns of Engagement With an AI Conversational Agent for Mental Health and Associations With Anxiety and Depression: Cross-Sectional Study. JMIR mental health · 10 Aug 2026 PMID 42574544
- The chain-mediating role of anxiety and depression in the relationship between symptom clusters and perceived cognitive function in nasopharyngeal carcinoma survivors: a cross-sectional study of 556 participants. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 29 Jul 2026 PMID 42527676
- The Effect of Preoperative Chewing Gum on Anxiety and Postoperative Sore Throat in Patients Using a Laryngeal Mask Airway: A Randomized Controlled Trial. International journal of nursing practice · 16 Jul 2026 PMID 42460602
- Comparing machine and deep learning models for pediatric anxiety classification using structured EHRs and area-based measures of health data. PloS one · 12 May 2026 PMID 42118733
- Building and validating a stigma prediction model for overweight and obese patients with polycystic ovary syndrome (PCOS): A observational study. Medicine · 1 May 2026 PMID 42065211
- Elucidation of the mechanisms and therapeutic effects of Sini Decoction on anxiety induced by forced swimming stress in mice. Journal of ethnopharmacology · 27 Apr 2026 PMID 42044778
Resilience in Psychological Distress (5)
- Which resilience-related factors are important for anxiety, depression, and stress in cancer caregivers? Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 17 Jul 2026 PMID 42467380
- Tinnitus, hyperacusis and somatic complaints in a diverse Norwegian clinical population: implications for assessment and rehabilitation. Annals of medicine · 5 Jul 2026 PMID 42402048
- Non-pharmacological interventions for anxiety and depression in Parkinson's disease. The Cochrane database of systematic reviews · 24 Jun 2026 PMID 42339755
- Effects of Insomnia, Anxiety and Depression on Clinical Outcomes of Frozen Shoulder After Manipulation Under Anesthesia. Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 24 Jun 2026 PMID 42339703
- The Impact of Social Support on Anxiety and Depression in Colorectal Cancer Patients: The Mediating Role of Psychological Resilience. Journal of gastrointestinal cancer · 19 May 2026 PMID 42154392
Behavioral Mental Health Support (3)
- Effects of laughter yoga on reducing depression and anxiety in children with autism spectrum disorder and parenting stress in their parents: study protocol for a randomised-controlled feasibility trial. BMJ open · 16 Jun 2026 PMID 42303395
- 'It is just a prediction; it's, like, not fact': youth attitudes towards risk prediction tools and personalised preventive interventions for depression and anxiety. BMJ mental health · 6 May 2026 PMID 42091201
- Effectiveness of yoga therapy as an adjunct on mental health status, quality of life, and medication adherence among people living with HIV on antiretroviral therapy: A study protocol of a randomized controlled trial (ART YOGA). PloS one · 27 Apr 2026 PMID 42044105
Others — Symptoms and Quality of Life (7)
- Wearable-derived postdischarge mobility as a digital biomarker for 90-day readmission and mortality in metastatic cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 11 Sept 2026 PMID 42726154
- Effectiveness and cost-effectiveness of the Pain-at-Work Toolkit for improving work ability in adults with chronic pain: protocol for a cluster randomised controlled trial. BMJ open · 9 Sept 2026 PMID 42716686
- Essential Oil-herbal Sachet Intervention for Sleep Quality and Anxiety in Maintenance Hemodialysis: A Single-center Randomized Trial. Journal of visualized experiments : JoVE · 26 Aug 2026 PMID 42644519
- Health-related quality of life trajectories during analytical treatment interruptions in HIV cure-related studies and the influence of depression, anxiety, and resilience. HIV research & clinical practice · 6 Aug 2026 PMID 42559869
- Phase I/II Double-Blind, Randomized Controlled Trial of Medicinal Cannabis on Quality of Life and Symptoms in Advanced Cancer: RESONANCE Trial Protocol. Clinical therapeutics · 20 Jul 2026 PMID 42476829
- The effect of virtual reality glasses used during inhaler treatment on anxiety, fear and vital signs in children: a randomized controlled trial. European journal of pediatrics · 18 May 2026 PMID 42151606
- Multivariate Pattern Analysis Identifies Potential Intertrial Resting-State EEG Biomarkers in Fibromyalgia. The European journal of neuroscience · 27 Apr 2026 PMID 42045133
By study type
Clinical trials (9)
- Effectiveness and cost-effectiveness of the Pain-at-Work Toolkit for improving work ability in adults with chronic pain: protocol for a cluster randomised controlled trial. BMJ open · 9 Sept 2026 PMID 42716686
- Essential Oil-herbal Sachet Intervention for Sleep Quality and Anxiety in Maintenance Hemodialysis: A Single-center Randomized Trial. Journal of visualized experiments : JoVE · 26 Aug 2026 PMID 42644519
- Effectiveness and Cost-Effectiveness of the Tankevirus and Grubl Mental Health Apps Compared With a Placebo App-Mental Health Intervention With Digital Applications (MIND-APP): Protocol for a Randomized Controlled Researcher-Blinded Trial. JMIR research protocols · 10 Aug 2026 PMID 42575499
- Phase I/II Double-Blind, Randomized Controlled Trial of Medicinal Cannabis on Quality of Life and Symptoms in Advanced Cancer: RESONANCE Trial Protocol. Clinical therapeutics · 20 Jul 2026 PMID 42476829
- Which resilience-related factors are important for anxiety, depression, and stress in cancer caregivers? Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 17 Jul 2026 PMID 42467380
- The Effect of Preoperative Chewing Gum on Anxiety and Postoperative Sore Throat in Patients Using a Laryngeal Mask Airway: A Randomized Controlled Trial. International journal of nursing practice · 16 Jul 2026 PMID 42460602
- Effects of laughter yoga on reducing depression and anxiety in children with autism spectrum disorder and parenting stress in their parents: study protocol for a randomised-controlled feasibility trial. BMJ open · 16 Jun 2026 PMID 42303395
- The effect of virtual reality glasses used during inhaler treatment on anxiety, fear and vital signs in children: a randomized controlled trial. European journal of pediatrics · 18 May 2026 PMID 42151606
- Effectiveness of yoga therapy as an adjunct on mental health status, quality of life, and medication adherence among people living with HIV on antiretroviral therapy: A study protocol of a randomized controlled trial (ART YOGA). PloS one · 27 Apr 2026 PMID 42044105
Observational studies and case reports (9)
- Wearable-derived postdischarge mobility as a digital biomarker for 90-day readmission and mortality in metastatic cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 11 Sept 2026 PMID 42726154
- Prevalence of anxiety and depression among in-patient and out-patient asthmatic patients in Jordan: A cross-sectional study. Medicine · 15 Aug 2026 PMID 42601735
- Patterns of Engagement With an AI Conversational Agent for Mental Health and Associations With Anxiety and Depression: Cross-Sectional Study. JMIR mental health · 10 Aug 2026 PMID 42574544
- The chain-mediating role of anxiety and depression in the relationship between symptom clusters and perceived cognitive function in nasopharyngeal carcinoma survivors: a cross-sectional study of 556 participants. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 29 Jul 2026 PMID 42527676
- Tinnitus, hyperacusis and somatic complaints in a diverse Norwegian clinical population: implications for assessment and rehabilitation. Annals of medicine · 5 Jul 2026 PMID 42402048
- Effects of Insomnia, Anxiety and Depression on Clinical Outcomes of Frozen Shoulder After Manipulation Under Anesthesia. Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 24 Jun 2026 PMID 42339703
- The Impact of Social Support on Anxiety and Depression in Colorectal Cancer Patients: The Mediating Role of Psychological Resilience. Journal of gastrointestinal cancer · 19 May 2026 PMID 42154392
- Comparing machine and deep learning models for pediatric anxiety classification using structured EHRs and area-based measures of health data. PloS one · 12 May 2026 PMID 42118733
- Building and validating a stigma prediction model for overweight and obese patients with polycystic ovary syndrome (PCOS): A observational study. Medicine · 1 May 2026 PMID 42065211
Human data, design not indexed (4)
- Health-related quality of life trajectories during analytical treatment interruptions in HIV cure-related studies and the influence of depression, anxiety, and resilience. HIV research & clinical practice · 6 Aug 2026 PMID 42559869
- Non-pharmacological interventions for anxiety and depression in Parkinson's disease. The Cochrane database of systematic reviews · 24 Jun 2026 PMID 42339755
- 'It is just a prediction; it's, like, not fact': youth attitudes towards risk prediction tools and personalised preventive interventions for depression and anxiety. BMJ mental health · 6 May 2026 PMID 42091201
- Multivariate Pattern Analysis Identifies Potential Intertrial Resting-State EEG Biomarkers in Fibromyalgia. The European journal of neuroscience · 27 Apr 2026 PMID 42045133
Preclinical: animal, cell and lab studies (1)
- Elucidation of the mechanisms and therapeutic effects of Sini Decoction on anxiety induced by forced swimming stress in mice. Journal of ethnopharmacology · 27 Apr 2026 PMID 42044778
Written from 23 PubMed abstracts, each one listed by PMID above. Published: 2026-06-15. Last written: 2026-09-13 by GPT. Drafted by language models from published abstracts; not medical advice.