Body mass index
Body mass index (BMI) is a clinical metric used to estimate relative adiposity from an individual’s weight and height.
Body mass index (BMI) is a clinical metric used to estimate relative adiposity from an individual’s weight and height. It is calculated as weight in kilograms divided by height in meters squared (kg/m²). In clinical and epidemiologic practice, BMI is widely used to classify underweight, normal weight, overweight, and obesity, and it serves as a practical surrogate marker for excess body mass in large populations and routine care.
Although BMI does not directly measure body composition, fat distribution, or metabolic health, it is strongly associated with a range of medical outcomes, including type 2 diabetes, hypertension, cardiovascular disease, inflammation, and chronic kidney disease. Because of its simplicity and standardization, BMI is often used alongside other measures such as waist circumference, body composition, and waist-to-height ratio to refine risk assessment, especially in settings where obesity-related risk may vary across sex, age, and disease context.
Where the papers sit
21 papers from the last 6 months study body mass index directly · updated from PubMed 10 Oct 2026
Study type 1 clinical trial · 14 observational · 5 human data · 1 unclassified
Themes 4 themes · 1 paradigm shift
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Obesity-Related Disease Risk
Obesity and body-fat distribution recur as markers of diabetes risk, treatment outcomes and vascular or surgical complications. In youth, BMI normalization is associated with lower progression to type 1 diabetes, while pregnancy glucose and pre-pregnancy BMI jointly predict gestational diabetes. Waist circumference and relative fat mass are tested against BMI for diabetes classification, with metabolic measures often adding information. Cancer, pulmonary embolism and renal disease studies show that BMI effects vary by disease, treatment and life stage.
9 papers · 42.9%
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Adiposity and Health Risk
Anthropometric measures are being evaluated as predictors of mortality, multimorbidity, treatment response and adiposity itself. Cox models and restricted cubic splines recur to capture nonlinear risk across BMI and related indices. Metabolic-inflammatory indices such as CTI extend prediction beyond body size in lymphoma and other conditions. DXA comparisons show that BMI can misclassify adiposity, leaving the best measure for healthy aging and clinical risk assessment unresolved.
5 papers · 23.8%
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Weight and Chronic Health
BMI and related weight indices are associated with headache, infertility, disabling arthritis and cardiopulmonary function. Vitamin D appears as a possible mediator of headache risk, while waist-based measures are compared with BMI for reproductive outcomes. Higher BMI is examined alongside exercise capacity in chronic coronary syndrome rather than as an isolated risk marker. The largely cross-sectional evidence maps associations, but does not establish a consistent causal or treatment direction.
4 papers · 19%
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Body Size and Cancer Treatment
Nutritional status, inflammation and body size are being used to explain variation in cancer treatment response and delivery. Geriatric Nutritional Risk Index and neutrophil-to-lymphocyte ratio provide prognostic context for intensive treatment. BMI is linked to differing responses to anti-PD-1 therapy in colorectal cancer. Radiotherapy studies focus on whether body habitus affects setup accuracy, while the optimal integration of nutritional and inflammatory measures remains open.
3 papers · 14.3%
BMI alone is not a reliable stand-in for adiposity or health risk
The DXA-based study of healthy Caucasian women found that BMI classified 40.3% as obese, whereas direct fat-mass measurement classified 72% as obese, showing substantial adiposity misclassification 42484670Jul. The diabetes-classification study across 82 low- and middle-income countries found that waist circumference and relative fat mass classified diabetes more accurately than BMI in both men and women 42623543Aug. The UK Biobank study of multimorbidity trajectories likewise found that central adiposity added risk discrimination beyond BMI, particularly among people in the overweight category 42457618Jul. Together, these findings replace the assumption that BMI is an adequate general measure of adiposity-related risk with an account in which direct fatness and fat distribution measures can reveal risk that BMI misses, changing both obesity classification and risk prediction.
Papers
The 21 papers from the last 6 months that study body mass index directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Obesity-Related Disease Risk (9)
- Combined predictive value of early pregnancy fasting plasma glucose and pre-pregnancy body mass index for gestational diabetes mellitus. African journal of reproductive health · 17 Sept 2026 PMID 42751463
- Waist Circumference, Relative Fat Mass Index, and BMI as Classifiers of Diabetes Status: A Comparative, Cross-sectional Analysis in 82 Low- and Middle-Income Countries. Diabetes care · 20 Aug 2026 PMID 42623543
- A study on risk factors for the progression from T2DM to end-stage renal disease based on Mendelian randomization and logistic regression analysis. Renal failure · 5 Aug 2026 PMID 42556871
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association · 31 Jul 2026 PMID 42535262
- The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States. Pediatric blood & cancer · 29 Jul 2026 PMID 42527845
- Obesity in pediatric type 1 diabetes: an underestimated health problem. Diabetes research and clinical practice · 25 Jul 2026 PMID 42501805
- Obesity and outcomes after esophagectomy: A nationwide population-based cohort study. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society · 20 Jul 2026 PMID 42473743
- BMI Normalization Is Associated With Lower Risk of Progression to Type 1 Diabetes, Primarily in Youth. Diabetes care · 16 Jul 2026 PMID 42461847
- Body mass index in postmenopausal women with estrogen receptor-positive, HER2-negative early breast cancer: An exploratory analysis of the LORELEI trial. European journal of cancer (Oxford, England : 1990) · 17 Jun 2026 PMID 42308863
Adiposity and Health Risk (5)
- Prognostic associations of anthropometric indices with major health outcomes: A nationwide cohort study of 1.1 million adults. PloS one · 24 Sept 2026 PMID 42784581
- Metabolic-inflammatory index CTI identifies high-risk early-stage natural killer/T-cell lymphoma and informs a novel prognostic model. Biomarker research · 17 Sept 2026 PMID 42750067
- Clinical predictors of early treatment response across systemic therapies in psoriasis: a prospective cohort study. The Journal of dermatological treatment · 13 Aug 2026 PMID 42592795
- Body mass index for the assessment of adiposity in healthy aging Caucasian women: a dual-energy X-ray absorptiometry based study. Rheumatology international · 22 Jul 2026 PMID 42484670
- Classification and Severity Assessment of Obesity in Clinical Risk Prediction of Multimorbidity Trajectories. Clinical obesity · 15 Jul 2026 PMID 42457618
Weight and Chronic Health (4)
- Association between body mass index and cardiopulmonary function in patients with chronic coronary syndrome. Annals of medicine · 28 Sept 2026 PMID 42803415
- Relationship of weight-adjusted waist index and body mass index with infertility: A NHANES 2015 to 2018 cross-sectional study. Medicine · 7 Aug 2026 PMID 42566560
- Pandemic-era changes in obesity-associated disabling arthritis burden among United States adults: a repeated cross-sectional study. Clinical rheumatology · 16 Jul 2026 PMID 42461567
- Vitamin D concentrations and headache risk in children and adolescents aged 6 to 19 years: The mediating role of body mass index. Medicine · 1 May 2026 PMID 42065159
Body Size and Cancer Treatment (3)
- Pretreatment Geriatric Nutritional Risk Index in RADPLAT-treated Patients With Oral Squamous Cell Carcinoma: A Pilot Study. In vivo (Athens, Greece) · 28 Aug 2026 PMID 42665408
- Body mass index and dyslipidemia influence responses to anti-PD-1 immunotherapy in colorectal cancer. Annals of medicine · 25 Aug 2026 PMID 42638413
- Surface-Guided Radiotherapy for Vulvar Cancer in the Frog-Leg Position: Setup Accuracy and BMI Effects. Journal of applied clinical medical physics · 26 Jul 2026 PMID 42503572
By study type
Clinical trials (1)
- Body mass index in postmenopausal women with estrogen receptor-positive, HER2-negative early breast cancer: An exploratory analysis of the LORELEI trial. European journal of cancer (Oxford, England : 1990) · 17 Jun 2026 PMID 42308863
Observational studies and case reports (14)
- Association between body mass index and cardiopulmonary function in patients with chronic coronary syndrome. Annals of medicine · 28 Sept 2026 PMID 42803415
- Prognostic associations of anthropometric indices with major health outcomes: A nationwide cohort study of 1.1 million adults. PloS one · 24 Sept 2026 PMID 42784581
- Combined predictive value of early pregnancy fasting plasma glucose and pre-pregnancy body mass index for gestational diabetes mellitus. African journal of reproductive health · 17 Sept 2026 PMID 42751463
- Body mass index and dyslipidemia influence responses to anti-PD-1 immunotherapy in colorectal cancer. Annals of medicine · 25 Aug 2026 PMID 42638413
- Waist Circumference, Relative Fat Mass Index, and BMI as Classifiers of Diabetes Status: A Comparative, Cross-sectional Analysis in 82 Low- and Middle-Income Countries. Diabetes care · 20 Aug 2026 PMID 42623543
- Clinical predictors of early treatment response across systemic therapies in psoriasis: a prospective cohort study. The Journal of dermatological treatment · 13 Aug 2026 PMID 42592795
- Relationship of weight-adjusted waist index and body mass index with infertility: A NHANES 2015 to 2018 cross-sectional study. Medicine · 7 Aug 2026 PMID 42566560
- A study on risk factors for the progression from T2DM to end-stage renal disease based on Mendelian randomization and logistic regression analysis. Renal failure · 5 Aug 2026 PMID 42556871
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association · 31 Jul 2026 PMID 42535262
- The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States. Pediatric blood & cancer · 29 Jul 2026 PMID 42527845
- Surface-Guided Radiotherapy for Vulvar Cancer in the Frog-Leg Position: Setup Accuracy and BMI Effects. Journal of applied clinical medical physics · 26 Jul 2026 PMID 42503572
- Obesity in pediatric type 1 diabetes: an underestimated health problem. Diabetes research and clinical practice · 25 Jul 2026 PMID 42501805
- Obesity and outcomes after esophagectomy: A nationwide population-based cohort study. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society · 20 Jul 2026 PMID 42473743
- Pandemic-era changes in obesity-associated disabling arthritis burden among United States adults: a repeated cross-sectional study. Clinical rheumatology · 16 Jul 2026 PMID 42461567
Human data, design not indexed (5)
- Pretreatment Geriatric Nutritional Risk Index in RADPLAT-treated Patients With Oral Squamous Cell Carcinoma: A Pilot Study. In vivo (Athens, Greece) · 28 Aug 2026 PMID 42665408
- Body mass index for the assessment of adiposity in healthy aging Caucasian women: a dual-energy X-ray absorptiometry based study. Rheumatology international · 22 Jul 2026 PMID 42484670
- BMI Normalization Is Associated With Lower Risk of Progression to Type 1 Diabetes, Primarily in Youth. Diabetes care · 16 Jul 2026 PMID 42461847
- Classification and Severity Assessment of Obesity in Clinical Risk Prediction of Multimorbidity Trajectories. Clinical obesity · 15 Jul 2026 PMID 42457618
- Vitamin D concentrations and headache risk in children and adolescents aged 6 to 19 years: The mediating role of body mass index. Medicine · 1 May 2026 PMID 42065159
Unclassified: not yet indexed with MeSH (1)
- Metabolic-inflammatory index CTI identifies high-risk early-stage natural killer/T-cell lymphoma and informs a novel prognostic model. Biomarker research · 17 Sept 2026 PMID 42750067
Written from 21 PubMed abstracts, each one listed by PMID above. Published: 2026-08-07. Last written: 2026-09-26 by GPT. Drafted by language models from published abstracts; not medical advice.