Wnt/β-catenin pathway
The Wnt/β-catenin pathway is a conserved cell-Signaling cascade that regulates embryonic development, tissue homeostasis, stem cell behavior, and cell fate decisions.
The Wnt/β-catenin pathway is a conserved cell-Signaling cascade that regulates embryonic development, tissue homeostasis, stem cell behavior, and cell fate decisions. In the canonical pathway, Wnt ligand stimulation stabilizes β-catenin, allowing it to accumulate and translocate to the nucleus, where it cooperates with transcriptional regulators such as TCF4 to drive expression of target genes including CCND1 and MYC proto-oncogene (MYC). When the pathway is not appropriately controlled, β-catenin signaling can become aberrantly activated and contribute to tumorigenesis, altered differentiation, fibrosis, and other disease processes.
In biomedical research, the pathway is frequently studied as both a mechanistic node and a therapeutic target. Recent studies in colorectal cancer, lung adenocarcinoma, breast cancer, skeletal aging, and fibrosis-associated models have examined how modulation of Wnt/β-catenin signaling intersects with inflammatory signaling, oxidative stress, ferroptosis, ER stress, ciliogenesis, and drug resistance. The pathway is also relevant in bone biology, where Wnt signaling supports bone health and inhibitors such as Sclerostin can influence skeletal deterioration.
Where the papers sit
15 papers from the last 6 months study wnt/β-catenin pathway directly · updated from PubMed 12 Oct 2026
Study type 0 clinical trials · 1 human data · 11 preclinical · 3 unclassified
Themes no clear themes · 1 new direction
Those 15 do not share a common subject.
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Canonical Wnt signaling is examined across unrelated disease contexts rather than a shared biological question. The reports address chemoresistant colorectal and thyroid cancer, glioblastoma immunotherapy, bone repair, spinal injury, neurodegeneration, obesity, hair biology and toxicology. Proposed interventions range from pathway inhibitors and natural products to scaffolds, electroacupuncture and nanoparticle delivery. The set provides no common endpoint or field-wide direction.
Wnt/β-catenin signaling is identified as a mediator linking food-chain-transferred nanoplastics to multiorgan fibrosis
Food-chain-transferred nanoplastics studied in a mealworm-to-mouse trophic-transfer model were found to activate Wnt and TGF-β signaling through dysregulation of genes including MTOR and FN1, thereby promoting fibrosis across organs 42103696May. Unlike the set’s uses of Wnt/β-catenin in cancer behavior, tissue repair, osteogenesis, skeletal aging, or metabolic regulation, this study assigns the pathway a distinct role in systemic environmental-toxicity-driven fibrotic disease, shifting it from a local disease or therapeutic mechanism to a mediator of cross-organ toxic injury.
Papers
The 15 papers from the last 6 months that study wnt/β-catenin pathway directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
No clear themes (15)
- Pharmacological inhibition of the canonical Wnt/β-catenin signaling pathway sensitizes 5-fluorouracil-resistant colorectal cancer cells. Molecular biology reports · 4 Sept 2026 PMID 42696229
- All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma. Signal transduction and targeted therapy · 25 Aug 2026 PMID 42642387
- A β-TCP/PMMA composite bone cement promotes osteogenic differentiation of osteoporotic rBMSCs via Wnt/β-catenin pathway. 3 Biotech · 9 Aug 2026 PMID 42571078
- Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling. Oncology reports · 24 Jul 2026 PMID 42495777
- Electroacupuncture-modulated DHCR24 facilitates spinal cord injury recovery by attenuating apoptosis and neuroinflammation via the Wnt signaling pathway. Metabolic brain disease · 2 Jul 2026 PMID 42390651
- Ionic liquid-coated Eudragit RS nanoparticles for topical delivery of honokiol to remodel the hair follicle microenvironment in androgenic alopecia. International journal of pharmaceutics · 17 Jun 2026 PMID 42309201
- Glycogen Synthase Kinase-3β Inhibition Ameliorates Synaptic and Mitochondrial Dysfunction in a Sporadic Alzheimer's Disease-Like Model. Molecular neurobiology · 17 Jun 2026 PMID 42307791
- Anti-obesity mechanisms of adzuki bean saponin: a multi-omics and experimental study. NPJ science of food · 5 Jun 2026 PMID 42248912
- Comprehensive multi-omics analysis identifies cancer subtypes and prognostic signatures of hepatitis B virus-associated hepatocellular carcinoma. NPJ precision oncology · 4 Jun 2026 PMID 42243437
- Flowerbed-Inspired Mg-Loaded Scaffold Accelerates Critical-Sized Bone-Defect Repair by Reprogramming the Microenvironment. ACS nano · 28 May 2026 PMID 42204979
- MicroRNA networks associated with skeletal aging and WNT pathway modulation. Calcified tissue international · 25 May 2026 PMID 42183846
- Cross-Organ Toxicity and Metabolic Responses to Food Chain-Transferred Nanoplastics: Mechanistic Insights from a Multiomics Perspective. ACS nano · 8 May 2026 PMID 42103696
- Transcriptomic alterations upon nuclear XIAP overexpression reveal IGFBP6/Wnt as a regulatory axis in breast cancer cell survival and chemoresistance. European journal of pharmacology · 2 May 2026 PMID 42069172
- PRDX4 Potentially Serves as an Independent Marker for Early Recurrence of Oral Squamous Cell Carcinoma. Anticancer research · 28 Apr 2026 PMID 42049339
- Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling. Cell reports. Medicine · 24 Apr 2026 PMID 42030933
By study type
Human data, design not indexed (1)
- PRDX4 Potentially Serves as an Independent Marker for Early Recurrence of Oral Squamous Cell Carcinoma. Anticancer research · 28 Apr 2026 PMID 42049339
Preclinical: animal, cell and lab studies (11)
- Pharmacological inhibition of the canonical Wnt/β-catenin signaling pathway sensitizes 5-fluorouracil-resistant colorectal cancer cells. Molecular biology reports · 4 Sept 2026 PMID 42696229
- All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma. Signal transduction and targeted therapy · 25 Aug 2026 PMID 42642387
- Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling. Oncology reports · 24 Jul 2026 PMID 42495777
- Electroacupuncture-modulated DHCR24 facilitates spinal cord injury recovery by attenuating apoptosis and neuroinflammation via the Wnt signaling pathway. Metabolic brain disease · 2 Jul 2026 PMID 42390651
- Ionic liquid-coated Eudragit RS nanoparticles for topical delivery of honokiol to remodel the hair follicle microenvironment in androgenic alopecia. International journal of pharmaceutics · 17 Jun 2026 PMID 42309201
- Glycogen Synthase Kinase-3β Inhibition Ameliorates Synaptic and Mitochondrial Dysfunction in a Sporadic Alzheimer's Disease-Like Model. Molecular neurobiology · 17 Jun 2026 PMID 42307791
- Flowerbed-Inspired Mg-Loaded Scaffold Accelerates Critical-Sized Bone-Defect Repair by Reprogramming the Microenvironment. ACS nano · 28 May 2026 PMID 42204979
- MicroRNA networks associated with skeletal aging and WNT pathway modulation. Calcified tissue international · 25 May 2026 PMID 42183846
- Cross-Organ Toxicity and Metabolic Responses to Food Chain-Transferred Nanoplastics: Mechanistic Insights from a Multiomics Perspective. ACS nano · 8 May 2026 PMID 42103696
- Transcriptomic alterations upon nuclear XIAP overexpression reveal IGFBP6/Wnt as a regulatory axis in breast cancer cell survival and chemoresistance. European journal of pharmacology · 2 May 2026 PMID 42069172
- Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling. Cell reports. Medicine · 24 Apr 2026 PMID 42030933
Unclassified: not yet indexed with MeSH (3)
- A β-TCP/PMMA composite bone cement promotes osteogenic differentiation of osteoporotic rBMSCs via Wnt/β-catenin pathway. 3 Biotech · 9 Aug 2026 PMID 42571078
- Anti-obesity mechanisms of adzuki bean saponin: a multi-omics and experimental study. NPJ science of food · 5 Jun 2026 PMID 42248912
- Comprehensive multi-omics analysis identifies cancer subtypes and prognostic signatures of hepatitis B virus-associated hepatocellular carcinoma. NPJ precision oncology · 4 Jun 2026 PMID 42243437
Written from 15 PubMed abstracts, each one listed by PMID above. Published: 2026-06-15. Last written: 2026-08-26 by GPT. Drafted by language models from published abstracts; not medical advice.