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Mechanistic target of rapamycin (mTOR)

The Mechanistic target of rapamycin kinase (Mtor) is a central serine/threonine kinase that integrates growth factor, nutrient, energy, and stress signals to regulate cell growth, metabolism, protein synthesis, autophagy, and survival.

Where the papers sit

24 papers from the last 6 months study Mechanistic target of rapamycin (mTOR) directly · updated from PubMed 12 Oct 2026

Study type 0 clinical trials · 3 observational · 2 human data · 16 preclinical · 3 unclassified

Themes one subject · 1 paradigm shift

Those 24 are all about one subject.

  • mTOR Signaling Across Diseases

    mTOR pathway dysregulation is being linked to cancer, cardiovascular disease, metabolic injury, fibrosis, infection and neurological complications. Autophagy, mitophagy, lipid or glutamine metabolism, inflammation and immune resistance recur as connecting mechanisms. Therapeutic work ranges from everolimus and direct mTOR inhibitors to metformin, urolithin A, artemisinin formulations and dual mTOR–GLS1 targeting. The evidence remains disease-specific, with no single clinical direction beyond broader exploration of mTOR modulation.

    24 papers

PARADIGM SHIFT

mTOR activation can support, rather than suppress, autophagy

The pancreatic ductal adenocarcinoma model treated with irinotecan and the asymmetric hydrogel model for diabetic foot ulcers instead show mTOR-associated autophagy activation: in pancreatic cancer, mTOR and autophagy remained coactivated through a JNK1–Beclin-1 pathway and sustained chemotherapy resistance, while in diabetic wounds, artemisinin and copper activated macrophage autophagy through PI3K/AKT/mTOR and AMPK/mTOR signaling. Together, these findings overturn the assumption that mTOR activation and autophagy are necessarily antagonistic; mTOR-directed strategies may need to account for context-dependent coactivation of autophagy rather than treating mTOR inhibition as its universal means of restoration. 42008004Apr 42409241Jul

Papers

The 24 papers from the last 6 months that study Mechanistic target of rapamycin (mTOR) directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.

By theme

mTOR Signaling Across Diseases (24)
  1. Clinical Characteristics and Outcomes of Patients with Lymphangioleiomyomatosis. Lung · 5 Oct 2026 PMID 42832099
  2. A novel mTORC1-NPC2 axis suppresses lipophagy and drives atherosclerotic plaque progression. Biochimica et biophysica acta. Molecular basis of disease · 9 Sept 2026 PMID 42716142
  3. Metabolic-epigenetic rewiring of CCR5hi monocytes sustains long-term trained immunity against lethal sepsis. Science advances · 21 Aug 2026 PMID 42627899
  4. Streptococcus anginosus-associated kynurenic acid drives PD-1 blockade resistance through an ITGA2-mTOR-CTSV axis in gastric cancer. Journal for immunotherapy of cancer · 6 Aug 2026 PMID 42562425
  5. Artemisinin liposomes regulates breast cancer metastasis and apoptosis through TIGIT/CD155 signal axis. Apoptosis : an international journal on programmed cell death · 27 Jul 2026 PMID 42507162
  6. Safety and efficacy of metformin for the treatment of pain: protocol for a systematic review. BMJ open · 17 Jul 2026 PMID 42468965
  7. A derivative of cytisine N-isoflavone from Sophora alopecuroides L., suppresses non-small cell lung cancer by targeting mTOR. European journal of pharmacology · 17 Jul 2026 PMID 42468678
  8. Urolithin A activates mitophagy via the AMPK-mTOR axis and modulates the gut-ceramide axis to ameliorate cardiac remodeling in HFpEF. Experimental & molecular medicine · 10 Jul 2026 PMID 42432192
  9. Molecular mechanisms of autophagy disorder in diabetic neuropathy: Focusing on signaling pathways and regulation of lipid metabolism. PloS one · 9 Jul 2026 PMID 42424320
  10. An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular Subgroups. Endocrine pathology · 9 Jul 2026 PMID 42424015
  11. Exosomes from diabetic perirenal adipose-derived MSCs promote inflammation and fibrosis in diabetic nephropathy via the miR-331-3p/TSC1/mTORC1 Axis. International immunopharmacology · 8 Jul 2026 PMID 42419147
  12. Everolimus and de novo malignancies after liver transplantation: A nationwide emulated trial using real-world data. JHEP reports : innovation in hepatology · 7 Jul 2026 PMID 42413767
  13. Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy. Journal of controlled release : official journal of the Controlled Release Society · 6 Jul 2026 PMID 42409241
  14. In Silico Discovery of mTOR Inhibitors as Potential Therapeutics for Feline Hypertrophic Cardiomyopathy. Journal of molecular modeling · 29 Jun 2026 PMID 42371166
  15. SMN haploinsufficiency exacerbates high glucose dialysate-induced peritoneal inflammation and fibrosis via mTOR/NFκB signaling pathway. Biochimica et biophysica acta. Molecular cell research · 19 Jun 2026 PMID 42320860
  16. Synergistic dual targeting of mTOR and GLS1 overcomes glutamine-driven resistance in triple-negative breast cancer. Pharmacological research · 11 Jun 2026 PMID 42276398
  17. Multi-mechanistic mitochondria-mediated N-methylated YKWYYRGAA-decorated nano-chitosan conjugate carrier for treatment of NRAS-mutant-harbouring lung carcinoma. Carbohydrate polymers · 2 Jun 2026 PMID 42230031
  18. Butyrate Regulates the Blood-Brain Barrier Transport and Intraendothelial Accumulation of Alzheimer's Disease Amyloid-Beta Peptides. Molecular pharmaceutics · 21 May 2026 PMID 42166642
  19. Platelet-rich plasma-primed bone marrow mesenchymal stem cell-derived exosomes inhibit neuronal apoptosis and autophagy, and promote nerve regeneration via the miR-29a-3p/PTEN/PI3K/Akt/mTOR axis after spinal cord injury. Journal of molecular histology · 21 May 2026 PMID 42165939
  20. Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway. International journal of molecular medicine · 15 May 2026 PMID 42138188
  21. Herb pair of Eucommiae Folium and Gardeniae Fructus enhanced hippocampal PACAP-mediated neuroplasticity via the non-classic downstream PI3K/AKT signaling to exert antidepressant effects. Journal of ethnopharmacology · 9 May 2026 PMID 42106016
  22. New Pathological Insights into Biomarkers for Multimodal Therapeutic Approach in Hepatic Neuroendocrine Tumors: A Detailed Case Report. In vivo (Athens, Greece) · 28 Apr 2026 PMID 42049452
  23. Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial. Nature medicine · 24 Apr 2026 PMID 42032072
  24. Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma. Cancer research · 20 Apr 2026 PMID 42008004

By study type

Observational studies and case reports (3)
  1. Clinical Characteristics and Outcomes of Patients with Lymphangioleiomyomatosis. Lung · 5 Oct 2026 PMID 42832099
  2. Everolimus and de novo malignancies after liver transplantation: A nationwide emulated trial using real-world data. JHEP reports : innovation in hepatology · 7 Jul 2026 PMID 42413767
  3. New Pathological Insights into Biomarkers for Multimodal Therapeutic Approach in Hepatic Neuroendocrine Tumors: A Detailed Case Report. In vivo (Athens, Greece) · 28 Apr 2026 PMID 42049452
Human data, design not indexed (2)
  1. Safety and efficacy of metformin for the treatment of pain: protocol for a systematic review. BMJ open · 17 Jul 2026 PMID 42468965
  2. An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular Subgroups. Endocrine pathology · 9 Jul 2026 PMID 42424015
Preclinical: animal, cell and lab studies (16)
  1. Metabolic-epigenetic rewiring of CCR5hi monocytes sustains long-term trained immunity against lethal sepsis. Science advances · 21 Aug 2026 PMID 42627899
  2. Streptococcus anginosus-associated kynurenic acid drives PD-1 blockade resistance through an ITGA2-mTOR-CTSV axis in gastric cancer. Journal for immunotherapy of cancer · 6 Aug 2026 PMID 42562425
  3. Artemisinin liposomes regulates breast cancer metastasis and apoptosis through TIGIT/CD155 signal axis. Apoptosis : an international journal on programmed cell death · 27 Jul 2026 PMID 42507162
  4. A derivative of cytisine N-isoflavone from Sophora alopecuroides L., suppresses non-small cell lung cancer by targeting mTOR. European journal of pharmacology · 17 Jul 2026 PMID 42468678
  5. Molecular mechanisms of autophagy disorder in diabetic neuropathy: Focusing on signaling pathways and regulation of lipid metabolism. PloS one · 9 Jul 2026 PMID 42424320
  6. Exosomes from diabetic perirenal adipose-derived MSCs promote inflammation and fibrosis in diabetic nephropathy via the miR-331-3p/TSC1/mTORC1 Axis. International immunopharmacology · 8 Jul 2026 PMID 42419147
  7. Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy. Journal of controlled release : official journal of the Controlled Release Society · 6 Jul 2026 PMID 42409241
  8. In Silico Discovery of mTOR Inhibitors as Potential Therapeutics for Feline Hypertrophic Cardiomyopathy. Journal of molecular modeling · 29 Jun 2026 PMID 42371166
  9. SMN haploinsufficiency exacerbates high glucose dialysate-induced peritoneal inflammation and fibrosis via mTOR/NFκB signaling pathway. Biochimica et biophysica acta. Molecular cell research · 19 Jun 2026 PMID 42320860
  10. Synergistic dual targeting of mTOR and GLS1 overcomes glutamine-driven resistance in triple-negative breast cancer. Pharmacological research · 11 Jun 2026 PMID 42276398
  11. Multi-mechanistic mitochondria-mediated N-methylated YKWYYRGAA-decorated nano-chitosan conjugate carrier for treatment of NRAS-mutant-harbouring lung carcinoma. Carbohydrate polymers · 2 Jun 2026 PMID 42230031
  12. Butyrate Regulates the Blood-Brain Barrier Transport and Intraendothelial Accumulation of Alzheimer's Disease Amyloid-Beta Peptides. Molecular pharmaceutics · 21 May 2026 PMID 42166642
  13. Platelet-rich plasma-primed bone marrow mesenchymal stem cell-derived exosomes inhibit neuronal apoptosis and autophagy, and promote nerve regeneration via the miR-29a-3p/PTEN/PI3K/Akt/mTOR axis after spinal cord injury. Journal of molecular histology · 21 May 2026 PMID 42165939
  14. Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway. International journal of molecular medicine · 15 May 2026 PMID 42138188
  15. Herb pair of Eucommiae Folium and Gardeniae Fructus enhanced hippocampal PACAP-mediated neuroplasticity via the non-classic downstream PI3K/AKT signaling to exert antidepressant effects. Journal of ethnopharmacology · 9 May 2026 PMID 42106016
  16. Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma. Cancer research · 20 Apr 2026 PMID 42008004
Unclassified: not yet indexed with MeSH (3)
  1. A novel mTORC1-NPC2 axis suppresses lipophagy and drives atherosclerotic plaque progression. Biochimica et biophysica acta. Molecular basis of disease · 9 Sept 2026 PMID 42716142
  2. Urolithin A activates mitophagy via the AMPK-mTOR axis and modulates the gut-ceramide axis to ameliorate cardiac remodeling in HFpEF. Experimental & molecular medicine · 10 Jul 2026 PMID 42432192
  3. Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial. Nature medicine · 24 Apr 2026 PMID 42032072
bioLLM/wiki is a literature-navigation aid for people who read primary research. It is not a medical resource, and it is not a substitute for a clinician, a pharmacist or the source papers themselves. Because the articles are drafted by language models, they can be incomplete or wrong in ways that read fluently. Please see the editorial policy and medical disclaimer before relying on anything here.

Written from 24 PubMed abstracts, each one listed by PMID above. Published: 2026-06-15. Last written: 2026-09-11 by GPT. Drafted by language models from published abstracts; not medical advice.