PI3K/AKT/mTOR pathway
The PI3K/AKT/mTOR pathway is a central intracellular signaling cascade that regulates cell growth, survival, metabolism, protein synthesis, autophagy, and stress responses.
The PI3K/AKT/mTOR pathway is a central intracellular signaling cascade that regulates cell growth, survival, metabolism, protein synthesis, autophagy, and stress responses. It is commonly activated by upstream growth factors and other extracellular cues, leading to sequential signaling through phosphoinositide 3-kinase (Phosphatidylinositol 3-kinase (PI3K)), Protein kinase B (PKB), and mechanistic target of rapamycin (Mtor). Because of its broad control over proliferation and survival, dysregulation of this pathway is implicated in cancer, inflammatory disease, aging-related decline, and other disorders.
In biomedical research, the PI3K/AKT/mTOR pathway is frequently studied as both a mechanistic node and a therapeutic target. Its activity is often interpreted alongside related regulators such as PTEN, Protein kinase B (PKB), PRKAA1/AMPK, Sirtuin 1 (SIRT1), MAPK signaling pathway, and Yes-associated protein 1 (YAP1), reflecting its integration with other growth and stress-response networks. Pharmacologic modulation of this pathway is also relevant to agents such as everolimus and sirolimus, which are used as pathway-directed comparators or interventions in translational studies.
Where the papers sit
15 papers from the last 6 months study PI3K/AKT/mTOR pathway directly · updated from PubMed 12 Oct 2026
Study type 0 clinical trials · 1 human data · 8 preclinical · 6 unclassified
Themes one subject
Those 15 are all about one subject.
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PI3K-Linked Disease Biology
PI3K-linked signaling is being studied as a shared mechanism across cancer, fibrosis, metabolic injury and tissue repair. The recurring endpoints are apoptosis, autophagy, epithelial-to-mesenchymal transition, ferroptosis and extracellular-matrix remodeling. Computational predictions and natural-product studies are moving toward experimental validation and drug combinations, but the disease contexts remain diverse. No single therapeutic direction or molecular subtype dominates this body of work.
Papers
The 15 papers from the last 6 months that study PI3K/AKT/mTOR pathway directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
PI3K-Linked Disease Biology (15)
- From in silico prediction to experimental validation: Identification of drugs and novel synergistic combinations that inhibit growth of inflammatory breast cancer cells. PloS one · 16 Sept 2026 PMID 42748134
- Alpinia Oxyphylla-Shenqi Siwu Decoction protects against high glucose-induced retinal pigment epithelial cell injury involving the PI3K/AKT/mTOR pathway. International ophthalmology · 10 Sept 2026 PMID 42720704
- MXRA5 promotes the progression and metastasis of breast cancer via activation of the epithelial-to-mesenchymal transition pathway. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 27 Aug 2026 PMID 42657493
- Loss of LCN2 Function Ameliorates Glucocorticoid-Induced Muscle Atrophy via Remodeling the Extracellular Matrix. Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 18 Aug 2026 PMID 42610529
- Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy. Journal of controlled release : official journal of the Controlled Release Society · 6 Jul 2026 PMID 42409241
- Synergistic inhibition of the PI3K-AKT-mTOR signaling pathway in idiopathic pulmonary fibrosis by Sanleng-Ezhu: a multi-omics and experimental study. Functional & integrative genomics · 26 Jun 2026 PMID 42362788
- Antitumor effect of the AP5Z1 small-molecule inhibitor PGG in hepatocellular carcinoma. Medical oncology (Northwood, London, England) · 25 Jun 2026 PMID 42347921
- High intrapancreatic fat deposition accelerates pancreatic ductal adenocarcinoma growth and metastasis with enrollment of FABP5 upregulation. Scientific reports · 6 Jun 2026 PMID 42251134
- Integrative Database-Driven In Silico and In Vitro Study of Anemarrhena asphodeloides Bunge Highlighting Hippeastrine as a Regulator of the HSP90/PI3K/Akt/mTOR Axis in Oral Squamous Cell Carcinoma. Advanced biology · 30 May 2026 PMID 42216572
- Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway. Oncology reports · 15 May 2026 PMID 42138203
- Herb pair of Eucommiae Folium and Gardeniae Fructus enhanced hippocampal PACAP-mediated neuroplasticity via the non-classic downstream PI3K/AKT signaling to exert antidepressant effects. Journal of ethnopharmacology · 9 May 2026 PMID 42106016
- Cross-Organ Toxicity and Metabolic Responses to Food Chain-Transferred Nanoplastics: Mechanistic Insights from a Multiomics Perspective. ACS nano · 8 May 2026 PMID 42103696
- STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells. Hereditas · 1 May 2026 PMID 42067902
- Next-Generation Therapies for Meningioma: Overcoming Barriers and Expanding Treatment Options. Cancer investigation · 22 Apr 2026 PMID 42017452
- HMGCS1 as a potential mediator of resistance to EZH2 inhibition via ferroptosis mediated by PI3K/AKT/mTOR pathway in the pancreatic neuroendocrine neoplasms. Endocrine-related cancer · 21 Apr 2026 PMID 42013002
By study type
Human data, design not indexed (1)
- Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway. Oncology reports · 15 May 2026 PMID 42138203
Preclinical: animal, cell and lab studies (8)
- From in silico prediction to experimental validation: Identification of drugs and novel synergistic combinations that inhibit growth of inflammatory breast cancer cells. PloS one · 16 Sept 2026 PMID 42748134
- Alpinia Oxyphylla-Shenqi Siwu Decoction protects against high glucose-induced retinal pigment epithelial cell injury involving the PI3K/AKT/mTOR pathway. International ophthalmology · 10 Sept 2026 PMID 42720704
- Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy. Journal of controlled release : official journal of the Controlled Release Society · 6 Jul 2026 PMID 42409241
- Antitumor effect of the AP5Z1 small-molecule inhibitor PGG in hepatocellular carcinoma. Medical oncology (Northwood, London, England) · 25 Jun 2026 PMID 42347921
- Integrative Database-Driven In Silico and In Vitro Study of Anemarrhena asphodeloides Bunge Highlighting Hippeastrine as a Regulator of the HSP90/PI3K/Akt/mTOR Axis in Oral Squamous Cell Carcinoma. Advanced biology · 30 May 2026 PMID 42216572
- Herb pair of Eucommiae Folium and Gardeniae Fructus enhanced hippocampal PACAP-mediated neuroplasticity via the non-classic downstream PI3K/AKT signaling to exert antidepressant effects. Journal of ethnopharmacology · 9 May 2026 PMID 42106016
- Cross-Organ Toxicity and Metabolic Responses to Food Chain-Transferred Nanoplastics: Mechanistic Insights from a Multiomics Perspective. ACS nano · 8 May 2026 PMID 42103696
- HMGCS1 as a potential mediator of resistance to EZH2 inhibition via ferroptosis mediated by PI3K/AKT/mTOR pathway in the pancreatic neuroendocrine neoplasms. Endocrine-related cancer · 21 Apr 2026 PMID 42013002
Unclassified: not yet indexed with MeSH (6)
- MXRA5 promotes the progression and metastasis of breast cancer via activation of the epithelial-to-mesenchymal transition pathway. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 27 Aug 2026 PMID 42657493
- Loss of LCN2 Function Ameliorates Glucocorticoid-Induced Muscle Atrophy via Remodeling the Extracellular Matrix. Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 18 Aug 2026 PMID 42610529
- Synergistic inhibition of the PI3K-AKT-mTOR signaling pathway in idiopathic pulmonary fibrosis by Sanleng-Ezhu: a multi-omics and experimental study. Functional & integrative genomics · 26 Jun 2026 PMID 42362788
- High intrapancreatic fat deposition accelerates pancreatic ductal adenocarcinoma growth and metastasis with enrollment of FABP5 upregulation. Scientific reports · 6 Jun 2026 PMID 42251134
- STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells. Hereditas · 1 May 2026 PMID 42067902
- Next-Generation Therapies for Meningioma: Overcoming Barriers and Expanding Treatment Options. Cancer investigation · 22 Apr 2026 PMID 42017452
Written from 15 PubMed abstracts, each one listed by PMID above. Published: 2026-07-02. Last written: 2026-09-18 by GPT. Drafted by language models from published abstracts; not medical advice.