cGAS-STING/NF-κB signaling pathway
The cGAS-STING/NF-κB signaling pathway is an innate immune signaling axis that links detection of cytosolic DNA to inflammatory gene expression.
The cGAS-STING/NF-κB signaling pathway is an innate immune signaling axis that links detection of cytosolic DNA to inflammatory gene expression. In this pathway, Cyclic GMP-AMP synthase (Cgas) senses aberrant DNA in the cytoplasm and activates Sting, which then promotes downstream signaling events that can converge on NF-κB activation. NF-κB is a central transcription factor controlling the expression of proinflammatory cytokines, chemokines, and other mediators of immune and stress responses.
Biologically, this pathway is important in host defense, but excessive or chronic activation can contribute to inflammatory tissue injury, tumor-promoting inflammation, and neuroinflammatory processes. Because of this dual role, the cGAS-STING/NF-κB signaling pathway is increasingly studied as a therapeutic target in cancer, inflammatory disease, and disorders involving sterile inflammation. In the recent literature provided here, it appears in the context of inflammatory and vascular remodeling in triple-negative breast cancer, where pathway inhibition was associated with suppression of the inflammatory microenvironment.
Where the papers sit
10 papers from the last 6 months study cGAS-STING/NF-κB signaling pathway directly · updated from PubMed 12 Oct 2026
Study type 0 clinical trials · 1 human data · 8 preclinical · 1 unclassified
Themes 3 themes
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NF-κB-Driven Inflammation
NF-κB suppression is being pursued across neuroinflammation, psoriasis, acute lung injury and arthritis-linked depressive behavior. Natural products, phloretin nanoparticles, gold nanoparticles and a MyD88 molecular glue target cytokine-producing pathways at different levels. Reduced inflammatory signaling and tissue or behavioral injury recur as endpoints. Shared mechanisms are stronger than evidence for any single therapy.
5 papers · 50%
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NF-κB in Gastrointestinal Disease
NF-κB-centered control of inflammation is being linked to metabolic, intestinal and colon-cancer phenotypes. Herbal formulations and acupuncture are paired with Nrf2/HO-1, p300/CBP, Ras/PI3K/Akt/mTOR and HDAC1/SREBP-1c mechanisms. The work remains preclinical, measuring cytokines, lipogenesis, apoptosis and tumor burden. Whether these pathways yield durable clinical benefit is unresolved.
3 papers · 30%
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Cellular Senescence and Inflammation
Cellular senescence links mtDNA stress, cGAS-STING-NF-κB activation and tissue damage. Emodin is being tested against radiation-induced pulmonary fibrosis, while TMAO connects gut metabolites to osteogenic dysfunction. Both studies favor reducing senescence rather than directly stimulating repair. Translation beyond preclinical models remains open.
2 papers · 20%
Papers
The 10 papers from the last 6 months that study cGAS-STING/NF-κB signaling pathway directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
NF-κB-Driven Inflammation (5)
- Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice. PloS one · 26 Jun 2026 PMID 42361074
- Design, Synthesis, and Biological Evaluation of a MyD88-Targeted Molecular Glue d21 for the Treatment of Acute Lung Injury. Journal of medicinal chemistry · 12 Jun 2026 PMID 42284437
- Targeted dermal delivery of phloretin via thermoresponsive nanoparticles potently suppresses STAT3/NF-κB-driven psoriatic inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology · 14 May 2026 PMID 42134228
- Exosomes from joints mediate depressive-like behaviors in MIA arthritis mice. Brain research bulletin · 10 May 2026 PMID 42107473
- Glutathione-conjugated gold nanoparticles mitigate amyloid-beta-induced neuroinflammation and tauopathy through inhibition of NF-κB, the NLRP3 inflammasome axis in 3D human neural stem cell models. Experimental cell research · 17 Apr 2026 PMID 41997281
NF-κB in Gastrointestinal Disease (3)
- Robinin Attenuates Xenobiotic Enzymes, Inflammation, and Apoptosis on DMH-Induced Colon Cancer via Modulating Ras/PI3K/Akt/mTOR and NF-κB/Bax/Caspase-3 Signalling Pathways in Wistar Rats. Journal of biochemical and molecular toxicology · 28 Jun 2026 PMID 42365609
- Huanglian Wendan Decoction attenuates hepatic inflammation and lipogenesis via inhibition of the NF-κB/HDAC1/SREBP-1c axis. Journal of ethnopharmacology · 11 Jun 2026 PMID 42276391
- Acupuncture enhances warm kidney and spleen granules efficacy in diabetic diarrhea through synergistic p300/CBP inhibition and Nrf2/HO-1 pathway activation. Molecular immunology · 9 May 2026 PMID 42105678
Cellular Senescence and Inflammation (2)
- Emodin alleviates radiation-induced pulmonary fibrosis by targeting cellular senescence via the mtDNA-cGAS-STING axis. Biogerontology · 6 Jul 2026 PMID 42405973
- Gut Microbiota-Derived TMAO Drives MC3T3-E1 Senescence and Osteogenic Dysfunction via cGAS-STING-NF-κB Signaling: Implications for Age-Related Bone Loss. Calcified tissue international · 28 Jun 2026 PMID 42366244
By study type
Human data, design not indexed (1)
- Glutathione-conjugated gold nanoparticles mitigate amyloid-beta-induced neuroinflammation and tauopathy through inhibition of NF-κB, the NLRP3 inflammasome axis in 3D human neural stem cell models. Experimental cell research · 17 Apr 2026 PMID 41997281
Preclinical: animal, cell and lab studies (8)
- Emodin alleviates radiation-induced pulmonary fibrosis by targeting cellular senescence via the mtDNA-cGAS-STING axis. Biogerontology · 6 Jul 2026 PMID 42405973
- Gut Microbiota-Derived TMAO Drives MC3T3-E1 Senescence and Osteogenic Dysfunction via cGAS-STING-NF-κB Signaling: Implications for Age-Related Bone Loss. Calcified tissue international · 28 Jun 2026 PMID 42366244
- Robinin Attenuates Xenobiotic Enzymes, Inflammation, and Apoptosis on DMH-Induced Colon Cancer via Modulating Ras/PI3K/Akt/mTOR and NF-κB/Bax/Caspase-3 Signalling Pathways in Wistar Rats. Journal of biochemical and molecular toxicology · 28 Jun 2026 PMID 42365609
- Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice. PloS one · 26 Jun 2026 PMID 42361074
- Design, Synthesis, and Biological Evaluation of a MyD88-Targeted Molecular Glue d21 for the Treatment of Acute Lung Injury. Journal of medicinal chemistry · 12 Jun 2026 PMID 42284437
- Targeted dermal delivery of phloretin via thermoresponsive nanoparticles potently suppresses STAT3/NF-κB-driven psoriatic inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology · 14 May 2026 PMID 42134228
- Exosomes from joints mediate depressive-like behaviors in MIA arthritis mice. Brain research bulletin · 10 May 2026 PMID 42107473
- Acupuncture enhances warm kidney and spleen granules efficacy in diabetic diarrhea through synergistic p300/CBP inhibition and Nrf2/HO-1 pathway activation. Molecular immunology · 9 May 2026 PMID 42105678
Unclassified: not yet indexed with MeSH (1)
- Huanglian Wendan Decoction attenuates hepatic inflammation and lipogenesis via inhibition of the NF-κB/HDAC1/SREBP-1c axis. Journal of ethnopharmacology · 11 Jun 2026 PMID 42276391
Written from 10 PubMed abstracts, each one listed by PMID above. Published: 2026-06-16. Last written: 2026-08-26 by GPT. Drafted by language models from published abstracts; not medical advice.