Metabolic syndrome
Metabolic syndrome (MetS) is a clinical clustering of cardiometabolic abnormalities that commonly includes abdominal obesity, dyslipidemia, elevated blood pressure, and impaired glucose regulation.
Metabolic syndrome (MetS) is a clinical clustering of cardiometabolic abnormalities that commonly includes abdominal obesity, dyslipidemia, elevated blood pressure, and impaired glucose regulation. It is not a single disease but a risk state defined by the co-occurrence of these interrelated metabolic disturbances, which together increase the likelihood of type 2 diabetes, cardiovascular disease, and other complications. In the biomedical literature, MetS is often discussed in relation to insulin resistance, systemic inflammation, HDL cholesterol abnormalities, waist circumference, blood pressure, and broader cardiometabolic risk.
Biologically, MetS reflects disrupted energy and lipid handling, altered metabolic pathways, and chronic low-grade inflammation. It is frequently studied alongside obesity, hypertension, diabetes, hemoglobin A1c, serum uric acid, dyslipidemia, and metabolic dysfunction–associated steatotic liver disease, because these conditions can overlap mechanistically and clinically. Research on MetS therefore spans epidemiology, physiology, and biomarker studies, as well as prevention-oriented work involving diet, physical fitness, body weight, and environmental or occupational exposures.
Where the papers sit
10 papers from the last 6 months study metabolic syndrome directly · updated from PubMed 1 Oct 2026
Study type 0 clinical trials · 7 observational · 2 human data · 1 unclassified
Themes one subject · 1 new direction
Those 10 are all about one subject.
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Metabolic Syndrome Epidemiology
Risk profiling spans inflammation, body composition, diet, occupational exposures and medication burden. CRP and fibrinogen, metabolomic signatures, lean-mass ratios and heavy-metal exposure recur as candidate markers or correlates. Associations extend across people living with HIV, older adults, military personnel, people with epilepsy, pregnant patients and those at risk for MASLD. The literature remains broad and observational, without a single established causal pathway or consistent clinical intervention.
Metabolic syndrome may predict treatment response in epilepsy rather than simply mark adverse metabolic risk
Patients with epilepsy, including those with drug-resistant and well-controlled disease, were studied to test whether metabolic syndrome was associated with drug resistance 42629660Aug. The expected role was a metabolic and inflammatory comorbidity that might worsen epilepsy outcomes, but metabolic syndrome was more prevalent in well-controlled epilepsy than in drug-resistant epilepsy and predicted treatment response. This places metabolic syndrome in a treatment-response and prognostic role not used by the other papers, although the cross-sectional design does not establish causation.
Papers
The 10 papers from the last 6 months that study metabolic syndrome directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Metabolic Syndrome Epidemiology (10)
- Beyond traditional criteria: CRP and fibrinogen as biomarkers of metabolic syndrome in ART-treated people living with HIV and their association with HIF-1α rs11549465. PloS one · 8 Sept 2026 PMID 42709845
- Metabolic syndrome identifies a high-risk polypharmacy phenotype in older adults with syncope. Pharmacological research · 31 Aug 2026 PMID 42674124
- Appendicular-to-trunk lean mass ratio resolves the height-based normalization paradox in low muscle mass and metabolic syndrome: A population-based cross-sectional study. PloS one · 25 Aug 2026 PMID 42640971
- Is there an association between metabolic syndrome and drug resistance in patients with epilepsy? Medicine · 22 Aug 2026 PMID 42629660
- Work stress, dietary patterns and metabolic syndrome among military personnel in Ghana: a cross-sectional study. BMJ open · 10 Aug 2026 PMID 42575550
- Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome. American journal of physiology. Gastrointestinal and liver physiology · 7 Aug 2026 PMID 42563426
- Association between the inflammatory potential of the diet and incidence of metabolic syndrome in middle-aged adults. Clinical nutrition (Edinburgh, Scotland) · 11 Jun 2026 PMID 42275990
- The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction-associated steatotic liver disease. Science advances · 13 May 2026 PMID 42127175
- Associations of occupational exposure to multiple heavy metals and metabolic syndrome among metal foundry workers: a cross‑sectional study. BMC endocrine disorders · 12 May 2026 PMID 42115867
- Severe maternal morbidity in patients of advanced maternal age with and without metabolic syndrome. Archives of gynecology and obstetrics · 5 May 2026 PMID 42084631
By study type
Observational studies and case reports (7)
- Beyond traditional criteria: CRP and fibrinogen as biomarkers of metabolic syndrome in ART-treated people living with HIV and their association with HIF-1α rs11549465. PloS one · 8 Sept 2026 PMID 42709845
- Appendicular-to-trunk lean mass ratio resolves the height-based normalization paradox in low muscle mass and metabolic syndrome: A population-based cross-sectional study. PloS one · 25 Aug 2026 PMID 42640971
- Is there an association between metabolic syndrome and drug resistance in patients with epilepsy? Medicine · 22 Aug 2026 PMID 42629660
- Work stress, dietary patterns and metabolic syndrome among military personnel in Ghana: a cross-sectional study. BMJ open · 10 Aug 2026 PMID 42575550
- Association between the inflammatory potential of the diet and incidence of metabolic syndrome in middle-aged adults. Clinical nutrition (Edinburgh, Scotland) · 11 Jun 2026 PMID 42275990
- Associations of occupational exposure to multiple heavy metals and metabolic syndrome among metal foundry workers: a cross‑sectional study. BMC endocrine disorders · 12 May 2026 PMID 42115867
- Severe maternal morbidity in patients of advanced maternal age with and without metabolic syndrome. Archives of gynecology and obstetrics · 5 May 2026 PMID 42084631
Human data, design not indexed (2)
- Metabolic syndrome identifies a high-risk polypharmacy phenotype in older adults with syncope. Pharmacological research · 31 Aug 2026 PMID 42674124
- The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction-associated steatotic liver disease. Science advances · 13 May 2026 PMID 42127175
Unclassified: not yet indexed with MeSH (1)
- Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome. American journal of physiology. Gastrointestinal and liver physiology · 7 Aug 2026 PMID 42563426
Written from 10 PubMed abstracts, each one listed by PMID above. Published: 2026-08-13. Last written: 2026-09-10 by GPT. Drafted by language models from published abstracts; not medical advice.