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Hemoglobin A1c

Hemoglobin A1c (HbA1c) is a glycated form of hemoglobin that reflects the proportion of hemoglobin molecules in red blood cells that have undergone non-enzymatic glycation by circulating glucose.

Where the papers sit

23 papers from the last 6 months study Hemoglobin A1c directly · updated from PubMed 8 Oct 2026

Study type 4 clinical trials · 11 observational · 8 human data

Themes one subject · 1 new direction

Those 23 are all about one subject.

  • Diabetes Management and Glycemic Control

    Glycemic control remains the shared focus across diabetes care, lifestyle intervention, medication use, self-management, and clinical outcomes. HbA1c recurs as a measure of treatment response and risk alongside weight, glucose monitoring, complications, fetal growth, and mortality. The literature favors practical, patient-centered approaches, including food access, culturally tailored education, adherence support, and newer glucose-lowering therapies. No single intervention or disease subgroup dominates, leaving the overall direction broad rather than centered on one strategy.

    23 papers

NEW DIRECTION

HbA1c becomes a contextualized measurement requiring simultaneous total-hemoglobin assessment

The dual-target SERS immunosensor study of simultaneous hemoglobin and glycated hemoglobin detection in human whole blood treats HbA1c not simply as a standalone indicator of long-term glycemic control, but as one component of a paired measurement whose interpretation depends on total hemoglobin 42478624Jul. It argues that relying on the absolute HbA1c amount can misjudge glycemic status and therefore develops a point-of-care assay that captures HbA1c and hemoglobin together, changing the role of HbA1c from an independently interpreted analyte to a value requiring hematologic context.

Papers

The 23 papers from the last 6 months that study Hemoglobin A1c directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.

By theme

Diabetes Management and Glycemic Control (23)
  1. Association of diabetes medication adherence quality measure performance with A1c control among Medicare Advantage beneficiaries. Journal of managed care & specialty pharmacy · 29 Sept 2026 PMID 42808547
  2. Hemoglobin A1c and Weight Changes Associated With Grocery Delivery and Low-Carbohydrate Education in Adults With Type 2 Diabetes and Food Insecurity: Observational Quality Improvement Cohort Study. JMIR formative research · 21 Sept 2026 PMID 42766389
  3. Muscle strength and HbA1c in geriatric patients with and without diabetes: a retrospective observational cohort study. Journal of endocrinological investigation · 24 Aug 2026 PMID 42635904
  4. Patient empowerment and glycemic control among adults with type 2 diabetes in Madinah, Saudi Arabia: A cross-sectional study. Medicine · 15 Aug 2026 PMID 42601730
  5. Effects of gestational weight gain and HbA1C on fetal growth and birthweight in women with obesity. Acta obstetricia et gynecologica Scandinavica · 12 Aug 2026 PMID 42583737
  6. Efficacy and safety of once-weekly subcutaneous zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in type 2 diabetes: a multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial. Lancet (London, England) · 30 Jul 2026 PMID 42532080
  7. Efficacy of co-created, culturally-sensitive intervention for type 2 diabetes self-management education in immigrants in Italy: The DiabEthic randomized clinical trial. Diabetes research and clinical practice · 28 Jul 2026 PMID 42520979
  8. Obesity in pediatric type 1 diabetes: an underestimated health problem. Diabetes research and clinical practice · 25 Jul 2026 PMID 42501805
  9. Dual-Target Immunosensor Based on SERS for Simultaneous Sensing of Hemoglobin and Glycated Hemoglobin in Human Whole Blood. Analytical chemistry · 21 Jul 2026 PMID 42478624
  10. Effects of a "Food Is Medicine" Intervention on Glucose Control Among Medicaid-Insured Patients With Type 2 Diabetes: A Randomized Controlled Trial. Circulation · 21 Jul 2026 PMID 42478360
  11. Correlates of Glycemic Status Among American Indian Adults With Type 2 Diabetes in Rural Southeastern Oklahoma. Nursing research · 20 Jul 2026 PMID 42474381
  12. Analysis of risk factors for early elevated intraocular pressure after vitrectomy in patients with diabetes. Medicine · 18 Jul 2026 PMID 42470071
  13. Compliance With Foot Care Practices Among Patients With Diabetes Mellitus in Sudan. International wound journal · 30 Jun 2026 PMID 42380043
  14. Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes. Clinical chemistry · 25 Jun 2026 PMID 42348255
  15. Larks vs. owls: exploring chronotype, glycaemic control, and quality of life in paediatric type 1 diabetes. Journal of pediatric endocrinology & metabolism : JPEM · 25 Jun 2026 PMID 42345257
  16. Mortality among patients with diabetic foot ulcers and its relationship with Wagner classification and glucose regulation. The National medical journal of India · 22 Jun 2026 PMID 42325033
  17. HbA1c improvement in pregnant women with type 1 diabetes using the CamAPS FX automated insulin delivery (AID) system: Clinical and economic outcomes. Diabetic medicine : a journal of the British Diabetic Association · 22 Jun 2026 PMID 42324667
  18. Higher HbA1c Following Younger Age of Transfer From Pediatric to Adult Type 1 Diabetes Services: Data From the Australasian Diabetes Data Network (ADDN) Registry. Diabetes care · 28 May 2026 PMID 42207931
  19. The 1-hour plasma glucose as a specific marker for early-phase insulin secretory defects in young adults with obesity. Diabetes research and clinical practice · 25 May 2026 PMID 42184890
  20. Community pharmacy-led diabetes management using continuous glucose monitoring for suboptimally controlled type 2 diabetes: A pilot feasibility study. PloS one · 22 May 2026 PMID 42172231
  21. Assessing the efficacy, safety and utility of fully closed-loop insulin delivery compared to standard insulin therapy with a continuous glucose monitor in adults with type 2 diabetes (COYOTE study): a randomised parallel study protocol. BMJ open · 19 May 2026 PMID 42156154
  22. EurA1c: a review of 9 years performance of up to 5120 laboratories in 29 country and 26 manufacturer groups according to current and proposed criteria of the IFCC Model for Quality Targets in relation to the use of HbA1c for monitoring and diagnosis of diabetes. Clinical chemistry and laboratory medicine · 18 May 2026 PMID 42149090
  23. Examining HbA1c in Frail Older Adults: A Linked Data Cohort Study. Australasian journal on ageing · 21 Apr 2026 PMID 42010844

By study type

Clinical trials (4)
  1. Efficacy and safety of once-weekly subcutaneous zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in type 2 diabetes: a multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial. Lancet (London, England) · 30 Jul 2026 PMID 42532080
  2. Efficacy of co-created, culturally-sensitive intervention for type 2 diabetes self-management education in immigrants in Italy: The DiabEthic randomized clinical trial. Diabetes research and clinical practice · 28 Jul 2026 PMID 42520979
  3. Effects of a "Food Is Medicine" Intervention on Glucose Control Among Medicaid-Insured Patients With Type 2 Diabetes: A Randomized Controlled Trial. Circulation · 21 Jul 2026 PMID 42478360
  4. Assessing the efficacy, safety and utility of fully closed-loop insulin delivery compared to standard insulin therapy with a continuous glucose monitor in adults with type 2 diabetes (COYOTE study): a randomised parallel study protocol. BMJ open · 19 May 2026 PMID 42156154
Observational studies and case reports (11)
  1. Association of diabetes medication adherence quality measure performance with A1c control among Medicare Advantage beneficiaries. Journal of managed care & specialty pharmacy · 29 Sept 2026 PMID 42808547
  2. Hemoglobin A1c and Weight Changes Associated With Grocery Delivery and Low-Carbohydrate Education in Adults With Type 2 Diabetes and Food Insecurity: Observational Quality Improvement Cohort Study. JMIR formative research · 21 Sept 2026 PMID 42766389
  3. Muscle strength and HbA1c in geriatric patients with and without diabetes: a retrospective observational cohort study. Journal of endocrinological investigation · 24 Aug 2026 PMID 42635904
  4. Patient empowerment and glycemic control among adults with type 2 diabetes in Madinah, Saudi Arabia: A cross-sectional study. Medicine · 15 Aug 2026 PMID 42601730
  5. Effects of gestational weight gain and HbA1C on fetal growth and birthweight in women with obesity. Acta obstetricia et gynecologica Scandinavica · 12 Aug 2026 PMID 42583737
  6. Obesity in pediatric type 1 diabetes: an underestimated health problem. Diabetes research and clinical practice · 25 Jul 2026 PMID 42501805
  7. Analysis of risk factors for early elevated intraocular pressure after vitrectomy in patients with diabetes. Medicine · 18 Jul 2026 PMID 42470071
  8. Compliance With Foot Care Practices Among Patients With Diabetes Mellitus in Sudan. International wound journal · 30 Jun 2026 PMID 42380043
  9. Larks vs. owls: exploring chronotype, glycaemic control, and quality of life in paediatric type 1 diabetes. Journal of pediatric endocrinology & metabolism : JPEM · 25 Jun 2026 PMID 42345257
  10. Higher HbA1c Following Younger Age of Transfer From Pediatric to Adult Type 1 Diabetes Services: Data From the Australasian Diabetes Data Network (ADDN) Registry. Diabetes care · 28 May 2026 PMID 42207931
  11. Examining HbA1c in Frail Older Adults: A Linked Data Cohort Study. Australasian journal on ageing · 21 Apr 2026 PMID 42010844
Human data, design not indexed (8)
  1. Dual-Target Immunosensor Based on SERS for Simultaneous Sensing of Hemoglobin and Glycated Hemoglobin in Human Whole Blood. Analytical chemistry · 21 Jul 2026 PMID 42478624
  2. Correlates of Glycemic Status Among American Indian Adults With Type 2 Diabetes in Rural Southeastern Oklahoma. Nursing research · 20 Jul 2026 PMID 42474381
  3. Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes. Clinical chemistry · 25 Jun 2026 PMID 42348255
  4. Mortality among patients with diabetic foot ulcers and its relationship with Wagner classification and glucose regulation. The National medical journal of India · 22 Jun 2026 PMID 42325033
  5. HbA1c improvement in pregnant women with type 1 diabetes using the CamAPS FX automated insulin delivery (AID) system: Clinical and economic outcomes. Diabetic medicine : a journal of the British Diabetic Association · 22 Jun 2026 PMID 42324667
  6. The 1-hour plasma glucose as a specific marker for early-phase insulin secretory defects in young adults with obesity. Diabetes research and clinical practice · 25 May 2026 PMID 42184890
  7. Community pharmacy-led diabetes management using continuous glucose monitoring for suboptimally controlled type 2 diabetes: A pilot feasibility study. PloS one · 22 May 2026 PMID 42172231
  8. EurA1c: a review of 9 years performance of up to 5120 laboratories in 29 country and 26 manufacturer groups according to current and proposed criteria of the IFCC Model for Quality Targets in relation to the use of HbA1c for monitoring and diagnosis of diabetes. Clinical chemistry and laboratory medicine · 18 May 2026 PMID 42149090
bioLLM/wiki is a literature-navigation aid for people who read primary research. It is not a medical resource, and it is not a substitute for a clinician, a pharmacist or the source papers themselves. Because the articles are drafted by language models, they can be incomplete or wrong in ways that read fluently. Please see the editorial policy and medical disclaimer before relying on anything here.

Written from 23 PubMed abstracts, each one listed by PMID above. Published: 2026-08-06. Last written: 2026-09-23 by GPT. Drafted by language models from published abstracts; not medical advice.