Legal act

Recent Findings on legal act

• A study of a Danshensu derivative, OZD-1, investigated protection against cerebral ischemia–reperfusion injury through the PI3K–AKT–CREB pathway. Inhibitor of this pathway abolished OZD-1-associated increases in phosphorylated PI3K, AKT, and CREB and reversed effects on cell viability, migration, and tube formation, supporting the pathway as a mediator of the observed cellular responses 42069160May.

• In a polycystic ovary syndrome model, vitamin D was studied in relation to lipid metabolism in granulosa cells through an FABP3-associated PI3K/AKT pathway. The investigators evaluated FABP3, FASN, ATGL, PPARγ, phosphorylated PI3K and AKT, cell viability and proliferation, free fatty acid levels, and perilipin-2 expression, linking AKT-associated signaling to metabolic and cellular phenotypes in granulosa cells 42302377Jun.

• Notopterygium franchetii polysaccharide fractions were assessed in insulin-resistant HepG2 cells. The ANP-1 fraction enhanced glucose uptake and glycogen synthesis while activating IRS1/PI3K/AKT signaling, identifying this pathway as part of the reported response to the polysaccharide preparation 42493156Jul.

• Brigatinib-based targeted drug conjugates were investigated for pancreatic ductal adenocarcinoma. Their reported antitumor profile included inhibition of the EGFR/AKT pathway and induction of DNA double-strand breaks, indicating that AKT-associated signaling was one component of the compounds’ anticancer mechanism 42456413Jul.

• Sini Decoction was examined in mice exposed to forced-swimming stress as a model of anxiety-related responses. Network pharmacology, molecular docking, and experimental validation implicated the PI3K/Akt signaling pathway; 6-gingerol and licochalcone B were reported to bind stably to core targets. Sini Decoction downregulated PI3K and Akt proteins, and this effect was reversed by a PI3K agonist 42044778Apr.

• In rheumatoid arthritis research, Zhiwang decoction was evaluated for effects on inflammation and macrophage polarization. The study examined CCN1 expression, macrophage M1 polarization, and PI3K/AKT phosphorylation, placing AKT-associated signaling within the proposed mechanism of the decoction’s anti-inflammatory effects 42081959May.

• Buyang Huanwu decoction was studied after ischemic stroke. The reported mechanism involved activation of an Akt/PAK5/SNPH axis, which was associated with enhanced mitochondrial recruitment and axonal remodeling during neurological recovery 42134501May.

• A FAK inhibitor candidate, compound 7g, was investigated in colorectal cancer harboring KRAS mutations. In HCT116 xenografts, 7g produced a reported tumor-growth inhibition value of 66.5% at 90 mg/kg compared with the control group. Mechanistic analyses associated the compound with apoptosis, G2/M cell-cycle arrest, and inhibition of the FAK–AKT signaling pathway 42379010Jun.

• (S)-Pyrrolo[1,2-a]pyrazine-3-carboxamide analogs were developed as dual Akt/JNK modulators and were evaluated for antiproliferative effects in MDA-MB-468 cells. The study therefore treated AKT as one of two pharmacological signaling targets in a breast-cancer cell model 42660647Aug.

• An asymmetric hydrogel containing artemisinin and Cu²⁺ was investigated for diabetic foot-ulcer healing through modulation of macrophage autophagy. The treatment was reported to activate macrophage autophagy through PI3K/AKT/mTOR and AMPK/mTOR pathways, connecting AKT signaling with the autophagic response in the wound-healing model 42409241Jul.

• Quantitative drug-sensitivity profiling in nasopharyngeal carcinoma identified capivasertib as a selective candidate relative to nonmalignant cells. Capivasertib, described as an AKT inhibitor, showed selective inhibition of nasopharyngeal carcinoma cell viability, with reported IC₅₀ values ranging from nanomolar to low-micromolar concentrations 42314829Jun.

• Taraxerol was studied in cerebral ischemia–reperfusion injury, with emphasis on inflammation and ferroptosis through the AKT/NF-κB pathway. The AKT agonist SC79 was used in oxygen–glucose deprivation/reoxygenation-treated PC12 cells to examine the regulatory contribution of this pathway 42640695Aug.

• KS79356, a kynureninase inhibitor, was evaluated in triple-negative breast cancer. The compound attenuated the TNF-α/NFκB–CD44–Akt signaling axis, with reported reductions in proliferation, invasion, and trans-endothelial migration and induction of both early and late apoptosis in TNBC cells 42667332Aug.

• Cottonseed oil was investigated in traumatic brain injury. Its reported neuroprotective effects were associated with activation of the AKT/GSK-3β pathway, reflected by increased AKT phosphorylation at Ser473 and inhibitory phosphorylation of GSK-3β at Ser9. The study consequently linked AKT signaling with suppression of neuroinflammatory responses in the injury model 42668334Aug.