Caspase-1 (CASP1)
CASP1 encodes caspase-1, a cysteine protease best known for its central role in inflammasome signaling and pyroptotic cell death.
CASP1 encodes caspase-1, a cysteine protease best known for its central role in inflammasome signaling and pyroptotic cell death. In canonical innate immune pathways, caspase-1 is activated downstream of inflammasome complexes such as NLRP3, where it processes the pro-forms of interleukin-1 beta (IL-1β) and IL-18 into their mature, bioactive cytokines and can also cleave Gasdermin D (GSDMD) to drive membrane pore formation and pyroptosis. Through these functions, CASP1 links pathogen sensing, sterile inflammation, and tissue injury responses.
Because of this position in inflammatory signaling, CASP1 is frequently studied in diseases characterized by excessive inflammasome activation, including neuroinflammation, inflammatory bowel disease, rheumatoid arthritis, ischemia-reperfusion injury, cancer-associated inflammatory cell death, and degenerative disorders. In recent work, CASP1 has also been examined as a therapeutic target in combination with pathways involving toll like receptor 4 (TLR4), NF-κB, TXNIP/NLRP3, mitophagy, and Sirt1/HIF-1α, as well as with compounds such as sulforaphane, kaempferol, quercetin, apigenin, salidroside, emodin, and amygdalin.
Where the papers sit
15 papers from the last 6 months study Caspase-1 (CASP1) directly · updated from PubMed 10 Oct 2026
Study type 0 clinical trials · 12 preclinical · 3 unclassified
Themes one subject
Those 15 are all about one subject.
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Inflammation and Cell Death
CASP1-linked inflammation and regulated cell death are being treated as shared drivers of tissue injury, cancer progression, and immune dysfunction. Most interventions suppress upstream TLR4/NF-κB or NLRP3 signaling, limiting CASP1, GSDMD-mediated pyroptosis, and inflammatory damage in liver, brain, kidney, vascular, and joint disease. Other studies activate immunogenic cell death or reprogram cytokines to improve treatment-resistant myeloma and ovarian cancer immunity. Evidence remains largely preclinical and mechanism-focused, with no single therapeutic strategy established.
Papers
The 15 papers from the last 6 months that study Caspase-1 (CASP1) directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Inflammation and Cell Death (15)
- Bellidifolin alleviates doxorubicin-induced hepatotoxicity: a study integrating network pharmacology, molecular docking, and experimental validation. Die Naturwissenschaften · 22 Sept 2026 PMID 42771163
- Activating a novel cell death pathway to target PI-resistant multiple myeloma and enhance immunogenic cell death. Apoptosis : an international journal on programmed cell death · 7 Sept 2026 PMID 42704369
- Anti-neuroinflammatory and neuroprotective effects of sweroside and swertiamarin from Swertia bimaculata in an in vitro microglial activation model. Biochemical and biophysical research communications · 31 Aug 2026 PMID 42673911
- CASP1 as a key autophagy-related gene in atherosclerosis: Identification by bioinformatics analysis and experimental validation. PloS one · 19 Aug 2026 PMID 42616740
- Splicing-mediated control of hnRNPD isoform switching by SRSF2 drives PD-L1-dependent immune evasion in gallbladder cancer. Oncogene · 20 Jul 2026 PMID 42477458
- Non-absorbable antibiotics worsen alcohol-associated liver disease in gastric acid-suppressed mice. Gut microbes · 9 Jul 2026 PMID 42421214
- Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury. International journal of molecular medicine · 19 Jun 2026 PMID 42318970
- Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells. Molecular medicine reports · 19 Jun 2026 PMID 42318962
- Identification of potential targets of kaempferol for the treatment of intervertebral disc degeneration based on network pharmacology and multi-omics analysis. Naunyn-Schmiedeberg's archives of pharmacology · 12 Jun 2026 PMID 42283840
- Oxyphenbutazone suppresses non-canonical inflammasome activation and protects against LPS-induced sepsis. International immunopharmacology · 18 May 2026 PMID 42150290
- Superparamagnetic iron oxide nanoparticle-driven 3-aroyl-1,4-diarylpyrrole nanocomposites (ARDAP@SPION-PEI) mediate renal cancer cell PANoptosis by regulating chromatin accessibility. Molecular biomedicine · 15 May 2026 PMID 42138776
- A novel mRNA-based multi-cytokine strategy to reprogram the peritoneal tumor microenvironment in ovarian cancer. Journal of nanobiotechnology · 12 May 2026 PMID 42116169
- An Integrated Approach Combining Chemical Profiling, Network Pharmacology, and In Vitro Validation to Uncover the Multitarget Mechanisms of Naokang II Decoction against Vascular Dementia. Journal of natural products · 8 May 2026 PMID 42099108
- The "Tianyu" Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 25 Apr 2026 PMID 42033182
- Amygdalin attenuates post-ischemic neuroinflammation by targeting TLR4/NF-κB signaling and NLRP3 inflammasome in cerebral ischemia-reperfusion injury. European journal of pharmacology · 21 Apr 2026 PMID 42013993
By study type
Preclinical: animal, cell and lab studies (12)
- Bellidifolin alleviates doxorubicin-induced hepatotoxicity: a study integrating network pharmacology, molecular docking, and experimental validation. Die Naturwissenschaften · 22 Sept 2026 PMID 42771163
- Activating a novel cell death pathway to target PI-resistant multiple myeloma and enhance immunogenic cell death. Apoptosis : an international journal on programmed cell death · 7 Sept 2026 PMID 42704369
- Anti-neuroinflammatory and neuroprotective effects of sweroside and swertiamarin from Swertia bimaculata in an in vitro microglial activation model. Biochemical and biophysical research communications · 31 Aug 2026 PMID 42673911
- CASP1 as a key autophagy-related gene in atherosclerosis: Identification by bioinformatics analysis and experimental validation. PloS one · 19 Aug 2026 PMID 42616740
- Non-absorbable antibiotics worsen alcohol-associated liver disease in gastric acid-suppressed mice. Gut microbes · 9 Jul 2026 PMID 42421214
- Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury. International journal of molecular medicine · 19 Jun 2026 PMID 42318970
- Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells. Molecular medicine reports · 19 Jun 2026 PMID 42318962
- Oxyphenbutazone suppresses non-canonical inflammasome activation and protects against LPS-induced sepsis. International immunopharmacology · 18 May 2026 PMID 42150290
- Superparamagnetic iron oxide nanoparticle-driven 3-aroyl-1,4-diarylpyrrole nanocomposites (ARDAP@SPION-PEI) mediate renal cancer cell PANoptosis by regulating chromatin accessibility. Molecular biomedicine · 15 May 2026 PMID 42138776
- An Integrated Approach Combining Chemical Profiling, Network Pharmacology, and In Vitro Validation to Uncover the Multitarget Mechanisms of Naokang II Decoction against Vascular Dementia. Journal of natural products · 8 May 2026 PMID 42099108
- The "Tianyu" Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis Pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 25 Apr 2026 PMID 42033182
- Amygdalin attenuates post-ischemic neuroinflammation by targeting TLR4/NF-κB signaling and NLRP3 inflammasome in cerebral ischemia-reperfusion injury. European journal of pharmacology · 21 Apr 2026 PMID 42013993
Unclassified: not yet indexed with MeSH (3)
- Splicing-mediated control of hnRNPD isoform switching by SRSF2 drives PD-L1-dependent immune evasion in gallbladder cancer. Oncogene · 20 Jul 2026 PMID 42477458
- Identification of potential targets of kaempferol for the treatment of intervertebral disc degeneration based on network pharmacology and multi-omics analysis. Naunyn-Schmiedeberg's archives of pharmacology · 12 Jun 2026 PMID 42283840
- A novel mRNA-based multi-cytokine strategy to reprogram the peritoneal tumor microenvironment in ovarian cancer. Journal of nanobiotechnology · 12 May 2026 PMID 42116169
Written from 15 PubMed abstracts, each one listed by PMID above. Published: 2026-06-16. Last written: 2026-09-24 by GPT. Drafted by language models from published abstracts; not medical advice.