Statin

Where the papers sit

16 papers from the last 6 months study statin directly · updated from PubMed 11 Oct 2026

• Cardiovascular Prevention and Adherence

  Cardiovascular prevention is moving toward sustained statin use, intensive treatment after ischemic stroke, and support for patients with diabetes or hypertension. Adherence trajectories and health-coach mobile interventions address the persistent gap between prescribing and long-term lipid control. Combination strategies include statins with dapagliflozin and immediate intensive statin therapy alongside dual antiplatelet treatment. Benefit remains balanced against uncommon adverse effects such as perioral neuropathic symptoms.

  8 papers · 50%

• Statin Safety and Clinical Outcomes

  Statin research is linking exposure to survival, disease progression, dementia, and pregnancy outcomes across several clinical populations. Observational analyses suggest lower progression and mortality in non-cirrhotic primary biliary cholangitis and possible survival associations in ALS. Other work tests whether combined statin and antihypertensive therapy alters dementia risk, while cohort data examine first-trimester exposure and pregnancy outcomes. The field remains dependent on propensity-adjusted and time-to-event analyses, with causality and subgroup safety still unresolved.

  4 papers · 25%

• Cholesterol Signaling and Cancer

  Cholesterol-dependent signaling is emerging as a target for tumor migration and treatment resistance. In melanoma, cholesterol-driven PIEZO1 activation supports amoeboid migration, while simvastatin may restore cisplatin sensitivity in cervical cancer through caveolin-1 and PI3K/AKT suppression. Boolean modeling and transcriptomics are being used to define how statin–ezetimibe combinations alter cholesterol synthesis and import. Human analyses additionally question whether statin exposure influences neuropathic pain, leaving cancer mechanisms and systemic effects at different stages of evidence.

  4 papers · 25%