C-X-C motif chemokine ligand 8 (CXCL8)

Where the papers sit

16 papers from the last 6 months study C-X-C motif chemokine ligand 8 (CXCL8) directly · updated from PubMed 3 Oct 2026

• Neutrophil Inflammatory Biology

  Neutrophil activation is being connected to NETosis, extracellular-matrix remodeling, endothelial injury, and inflammatory disease. MMP-9 and NET formation recur in studies of dry eye, tumor progression, sepsis, and neurologic disorders. Proteomics, radiogenomics, and microphysiological systems are being used to link these mechanisms with disease severity and treatment response. The main open question is when neutrophils are protective and when they amplify tissue damage.

  8 papers · 50%

• Inflammatory Cytokine Signaling

  Inflammatory cytokine signaling is being linked to cancer progression, treatment-related physiology, and acute tissue injury. IL-6 and CXCL8 recur alongside tumor microenvironment changes, obesity-associated inflammation, and myofibro-inflammatory cancer-associated fibroblasts. Strength training during chemotherapy and blood–cerebrospinal fluid profiling broaden the focus beyond tumors. The work is moving toward context-specific cytokine panels and integrated cellular profiling rather than single-marker interpretation.

  4 papers · 25%

• Cytokine Biomarkers of Severity

  Serum IL-6 and CXCL8 are being evaluated as accessible markers for disease screening, severity grading, and short-term outcome prediction. Studies span diabetic retinopathy, diabetic foot ulcers, community-acquired and Mycoplasma pneumonia, and early myocardial injury. Associations with CURB-65, sST2, Th/Ts ratios, and area under the curve support multimarker risk stratification. External validation and clinically useful thresholds remain necessary before routine adoption.

  4 papers · 25%