Quercetin hydrogel
Quercetin hydrogel is a quercetin-containing hydrogel formulation designed to deliver the flavonoid quercetin in a localized, sustained, or otherwise bioavailable form. quercetin itself is a naturally occurring polyphenolic flavonoid widely found in medicinal and edible plants and is studied for a range of biological activities, including anti-inflammatory, antioxidant, barrier-protective, and anticancer effects.
Quercetin hydrogel is a quercetin-containing hydrogel formulation designed to deliver the flavonoid quercetin in a localized, sustained, or otherwise bioavailable form. quercetin itself is a naturally occurring polyphenolic flavonoid widely found in medicinal and edible plants and is studied for a range of biological activities, including anti-inflammatory, antioxidant, barrier-protective, and anticancer effects. In hydrogel form, quercetin is incorporated into a polymeric or self-assembling matrix to improve handling, retention at the target site, and therapeutic performance.
In biomedical research, quercetin hydrogel is of interest as a drug-delivery and tissue-repair platform rather than as a single molecular target. The available recent literature links quercetin-based interventions to cancer-related signaling pathways such as Insulin-like growth factor 1 (IGF-1) and EGFR, as well as to intestinal mucosal protection and wound healing. In the specific hydrogel study context, the formulation was investigated as a self-assembling system derived from Astragalus membranaceus and was reported to accelerate diabetic wound healing, suggesting a role in regenerative medicine and local therapy.
Where the papers sit
10 papers from the last 6 months study quercetin hydrogel directly · updated from PubMed 10 Oct 2026
Study type 0 clinical trials · 2 human data · 7 preclinical · 1 unclassified
Themes 3 themes
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Quercetin Therapeutic Research
Quercetin research here spans oral biofilms, reproductive toxicity, osteoarthritis, atherosclerosis and cancer. Localized sustained delivery is emphasized in the chlorhexidine-loaded PLGA nanoparticle study, while other work examines systemic metabolites or cellular senescence. Reported endpoints range from antimicrobial activity and sperm quality to chondrocyte aging and disease-associated macrophage states. The topics share the compound more than a biological question, so no common direction is established.
5 papers · 50%
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Cancer Growth Signaling
Quercetin is being investigated as a regulator of growth signaling in hepatocellular and gastric cancer. The recurring mechanisms involve EGFR and IGF1 pathways, with STAT3 and ESR1 appearing in broader network-based analyses. Molecular docking, network pharmacology and cell assays are being used to connect these signals with reduced proliferation or tumor progression. Evidence remains predominantly mechanistic and preclinical, with pathway-specific anticancer effects still requiring validation.
3 papers · 30%
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Nanocarrier Cancer Apoptosis
Combination nanocarriers are being developed to drive apoptosis in breast and colorectal cancer cells. One strategy co-delivers paclitaxel and quercetin through integrin αvβ3-targeted solid lipid nanoparticles, while another uses a quercetin-loaded orange-oil nanoemulsion. Apoptotic signaling and reduced cancer-cell viability are the shared endpoints. The work is moving toward localized combination delivery, but evidence remains limited to early cell-line studies.
2 papers · 20%
Papers
The 10 papers from the last 6 months that study quercetin hydrogel directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Quercetin Therapeutic Research (5)
- Preparation and In Vitro Characterization of Quercetin and Chlorhexidine-loaded PLGA Nanoparticles for Oral Biofilm-Associated Pathologies. Clinical oral investigations · 26 Jun 2026 PMID 42360515
- Niosomal l-carnitine and quercetin improve sperm quality and testicular function in atrazine-induced reproductive toxicity in rats. Scientific reports · 22 Jun 2026 PMID 42332019
- Decoding chromatin regulator-LAIR1+ M2 like macrophage patterns in atherosclerosis and clinical outcomes of Lung adenocarcinoma patients: evidence from artificial intelligence-driven multi omics and in vitro validation. Clinical and experimental medicine · 19 Jun 2026 PMID 42319401
- UPLC-Q-TOF-MS/MS-based dynamic metabolite profile analysis of Huangkui capsule in serum, urine, and feces from normal and pseudo-germ-free rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 29 Apr 2026 PMID 42054904
- Integrative transcriptomics and single-cell analysis unravel the senescence-reversing mechanism of quercetin in osteoarthritic chondrocytes. Biochemical and biophysical research communications · 24 Apr 2026 PMID 42030882
Cancer Growth Signaling (3)
- A network pharmacology-based approach and molecular docking study to explore the therapeutic potential of a nutraceutical formula (Vernolac) in the treatment of cancer. PloS one · 1 Jul 2026 PMID 42384725
- Quercetin targets IGF1 signaling in gastric cancer: a synergy of network pharmacology, molecular simulations, and in vitro functional assays. Journal of computer-aided molecular design · 15 Jun 2026 PMID 42295420
- Quercetin suppresses the progression of HBV-associated hepatocellular carcinoma by modulating the EGFR signaling pathway. PloS one · 12 Jun 2026 PMID 42284354
Nanocarrier Cancer Apoptosis (2)
- Low-energy spontaneous fabrication of quercetin-loaded orange oil nanoemulsion for induction of colorectal cancer cell apoptosis. BMC complementary medicine and therapies · 17 Jun 2026 PMID 42304318
- Integrin αvβ3-Targeted SLNs for Co-Delivery of Paclitaxel and Quercetin in Triple-Negative Breast Cancer. ACS applied materials & interfaces · 10 Jun 2026 PMID 42267862
By study type
Human data, design not indexed (2)
- Low-energy spontaneous fabrication of quercetin-loaded orange oil nanoemulsion for induction of colorectal cancer cell apoptosis. BMC complementary medicine and therapies · 17 Jun 2026 PMID 42304318
- Integrative transcriptomics and single-cell analysis unravel the senescence-reversing mechanism of quercetin in osteoarthritic chondrocytes. Biochemical and biophysical research communications · 24 Apr 2026 PMID 42030882
Preclinical: animal, cell and lab studies (7)
- A network pharmacology-based approach and molecular docking study to explore the therapeutic potential of a nutraceutical formula (Vernolac) in the treatment of cancer. PloS one · 1 Jul 2026 PMID 42384725
- Preparation and In Vitro Characterization of Quercetin and Chlorhexidine-loaded PLGA Nanoparticles for Oral Biofilm-Associated Pathologies. Clinical oral investigations · 26 Jun 2026 PMID 42360515
- Niosomal l-carnitine and quercetin improve sperm quality and testicular function in atrazine-induced reproductive toxicity in rats. Scientific reports · 22 Jun 2026 PMID 42332019
- Quercetin targets IGF1 signaling in gastric cancer: a synergy of network pharmacology, molecular simulations, and in vitro functional assays. Journal of computer-aided molecular design · 15 Jun 2026 PMID 42295420
- Quercetin suppresses the progression of HBV-associated hepatocellular carcinoma by modulating the EGFR signaling pathway. PloS one · 12 Jun 2026 PMID 42284354
- Integrin αvβ3-Targeted SLNs for Co-Delivery of Paclitaxel and Quercetin in Triple-Negative Breast Cancer. ACS applied materials & interfaces · 10 Jun 2026 PMID 42267862
- UPLC-Q-TOF-MS/MS-based dynamic metabolite profile analysis of Huangkui capsule in serum, urine, and feces from normal and pseudo-germ-free rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 29 Apr 2026 PMID 42054904
Unclassified: not yet indexed with MeSH (1)
- Decoding chromatin regulator-LAIR1+ M2 like macrophage patterns in atherosclerosis and clinical outcomes of Lung adenocarcinoma patients: evidence from artificial intelligence-driven multi omics and in vitro validation. Clinical and experimental medicine · 19 Jun 2026 PMID 42319401
Written from 10 PubMed abstracts, each one listed by PMID above. Published: 2026-06-16. Last written: 2026-08-26 by GPT. Drafted by language models from published abstracts; not medical advice.