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Quercetin hydrogel

Quercetin hydrogel is a quercetin-containing hydrogel formulation designed to deliver the flavonoid quercetin in a localized, sustained, or otherwise bioavailable form. quercetin itself is a naturally occurring polyphenolic flavonoid widely found in medicinal and edible plants and is studied for a range of biological activities, including anti-inflammatory, antioxidant, barrier-protective, and anticancer effects.

Where the papers sit

10 papers from the last 6 months study quercetin hydrogel directly · updated from PubMed 10 Oct 2026

Study type 0 clinical trials · 2 human data · 7 preclinical · 1 unclassified

Themes 3 themes

  • Quercetin Therapeutic Research

    Quercetin research here spans oral biofilms, reproductive toxicity, osteoarthritis, atherosclerosis and cancer. Localized sustained delivery is emphasized in the chlorhexidine-loaded PLGA nanoparticle study, while other work examines systemic metabolites or cellular senescence. Reported endpoints range from antimicrobial activity and sperm quality to chondrocyte aging and disease-associated macrophage states. The topics share the compound more than a biological question, so no common direction is established.

    5 papers · 50%

  • Cancer Growth Signaling

    Quercetin is being investigated as a regulator of growth signaling in hepatocellular and gastric cancer. The recurring mechanisms involve EGFR and IGF1 pathways, with STAT3 and ESR1 appearing in broader network-based analyses. Molecular docking, network pharmacology and cell assays are being used to connect these signals with reduced proliferation or tumor progression. Evidence remains predominantly mechanistic and preclinical, with pathway-specific anticancer effects still requiring validation.

    3 papers · 30%

  • Nanocarrier Cancer Apoptosis

    Combination nanocarriers are being developed to drive apoptosis in breast and colorectal cancer cells. One strategy co-delivers paclitaxel and quercetin through integrin αvβ3-targeted solid lipid nanoparticles, while another uses a quercetin-loaded orange-oil nanoemulsion. Apoptotic signaling and reduced cancer-cell viability are the shared endpoints. The work is moving toward localized combination delivery, but evidence remains limited to early cell-line studies.

    2 papers · 20%

Papers

The 10 papers from the last 6 months that study quercetin hydrogel directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.

By theme

Quercetin Therapeutic Research (5)
  1. Preparation and In Vitro Characterization of Quercetin and Chlorhexidine-loaded PLGA Nanoparticles for Oral Biofilm-Associated Pathologies. Clinical oral investigations · 26 Jun 2026 PMID 42360515
  2. Niosomal l-carnitine and quercetin improve sperm quality and testicular function in atrazine-induced reproductive toxicity in rats. Scientific reports · 22 Jun 2026 PMID 42332019
  3. Decoding chromatin regulator-LAIR1+ M2 like macrophage patterns in atherosclerosis and clinical outcomes of Lung adenocarcinoma patients: evidence from artificial intelligence-driven multi omics and in vitro validation. Clinical and experimental medicine · 19 Jun 2026 PMID 42319401
  4. UPLC-Q-TOF-MS/MS-based dynamic metabolite profile analysis of Huangkui capsule in serum, urine, and feces from normal and pseudo-germ-free rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 29 Apr 2026 PMID 42054904
  5. Integrative transcriptomics and single-cell analysis unravel the senescence-reversing mechanism of quercetin in osteoarthritic chondrocytes. Biochemical and biophysical research communications · 24 Apr 2026 PMID 42030882
Cancer Growth Signaling (3)
  1. A network pharmacology-based approach and molecular docking study to explore the therapeutic potential of a nutraceutical formula (Vernolac) in the treatment of cancer. PloS one · 1 Jul 2026 PMID 42384725
  2. Quercetin targets IGF1 signaling in gastric cancer: a synergy of network pharmacology, molecular simulations, and in vitro functional assays. Journal of computer-aided molecular design · 15 Jun 2026 PMID 42295420
  3. Quercetin suppresses the progression of HBV-associated hepatocellular carcinoma by modulating the EGFR signaling pathway. PloS one · 12 Jun 2026 PMID 42284354
Nanocarrier Cancer Apoptosis (2)
  1. Low-energy spontaneous fabrication of quercetin-loaded orange oil nanoemulsion for induction of colorectal cancer cell apoptosis. BMC complementary medicine and therapies · 17 Jun 2026 PMID 42304318
  2. Integrin αvβ3-Targeted SLNs for Co-Delivery of Paclitaxel and Quercetin in Triple-Negative Breast Cancer. ACS applied materials & interfaces · 10 Jun 2026 PMID 42267862

By study type

Human data, design not indexed (2)
  1. Low-energy spontaneous fabrication of quercetin-loaded orange oil nanoemulsion for induction of colorectal cancer cell apoptosis. BMC complementary medicine and therapies · 17 Jun 2026 PMID 42304318
  2. Integrative transcriptomics and single-cell analysis unravel the senescence-reversing mechanism of quercetin in osteoarthritic chondrocytes. Biochemical and biophysical research communications · 24 Apr 2026 PMID 42030882
Preclinical: animal, cell and lab studies (7)
  1. A network pharmacology-based approach and molecular docking study to explore the therapeutic potential of a nutraceutical formula (Vernolac) in the treatment of cancer. PloS one · 1 Jul 2026 PMID 42384725
  2. Preparation and In Vitro Characterization of Quercetin and Chlorhexidine-loaded PLGA Nanoparticles for Oral Biofilm-Associated Pathologies. Clinical oral investigations · 26 Jun 2026 PMID 42360515
  3. Niosomal l-carnitine and quercetin improve sperm quality and testicular function in atrazine-induced reproductive toxicity in rats. Scientific reports · 22 Jun 2026 PMID 42332019
  4. Quercetin targets IGF1 signaling in gastric cancer: a synergy of network pharmacology, molecular simulations, and in vitro functional assays. Journal of computer-aided molecular design · 15 Jun 2026 PMID 42295420
  5. Quercetin suppresses the progression of HBV-associated hepatocellular carcinoma by modulating the EGFR signaling pathway. PloS one · 12 Jun 2026 PMID 42284354
  6. Integrin αvβ3-Targeted SLNs for Co-Delivery of Paclitaxel and Quercetin in Triple-Negative Breast Cancer. ACS applied materials & interfaces · 10 Jun 2026 PMID 42267862
  7. UPLC-Q-TOF-MS/MS-based dynamic metabolite profile analysis of Huangkui capsule in serum, urine, and feces from normal and pseudo-germ-free rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 29 Apr 2026 PMID 42054904
Unclassified: not yet indexed with MeSH (1)
  1. Decoding chromatin regulator-LAIR1+ M2 like macrophage patterns in atherosclerosis and clinical outcomes of Lung adenocarcinoma patients: evidence from artificial intelligence-driven multi omics and in vitro validation. Clinical and experimental medicine · 19 Jun 2026 PMID 42319401