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Lactate

Lactate is a glycolysis-associated metabolite and an important clinical metric, studied both as a circulating indicator of physiological stress and as a regulator of cellular behavior.

Where the papers sit

15 papers from the last 6 months study lactate directly · updated from PubMed 3 Nov 2026

Study type 0 clinical trials · 2 observational · 5 human data · 4 preclinical · 4 unclassified

Themes one subject · 1 new direction

Those 15 are all about one subject.

  • Lactate Across Biology and Medicine

    Lactate research is expanding from a metabolic readout to a therapeutic and regulatory target. Cancer studies link lactate to immune suppression, PD-L1 stability and histone lactylation, while depletion strategies aim to restore antitumor or antimicrobial immunity. Clinical work uses lactate and lactate-to-albumin ratios for risk assessment in trauma, sepsis, pancreatitis and kidney disease. Sensors and rapid assays are advancing noninvasive or point-of-care measurement, while tissue studies test lactate-directed repair strategies.

    15 papers

NEW DIRECTION

Lactate depletion becomes an antibiotic-sensitizing mechanism in biofilm infection

Biofilm formation in implant-associated infections was assumed to make lactate relevant primarily as an immunosuppressive metabolite, but the LMVM nanotherapy study found that lactate oxidation also intensifies local hypoxia, redirects bacterial metabolism, activates metronidazole against tolerant subpopulations, and suppresses staphyloxanthin-dependent antioxidant defenses. This extends lactate targeting beyond immune-microenvironment reprogramming to direct metabolic control of antibiotic susceptibility in biofilms 42825697Oct.

Papers

The 15 papers from the last 6 months that study lactate directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.

By theme

Lactate Across Biology and Medicine (15)
  1. Lactate-Depleting Nanotherapy Reprograms the Immunometabolic Microenvironment to Overcome Biofilm Tolerance in Implant-Associated Infections. Advanced materials (Deerfield Beach, Fla.) · 2 Oct 2026 PMID 42825697
  2. Plasmon-enhanced molecularly imprinted photoelectrochemical sensor for non-invasive lactate monitoring in sweat. Chemical communications (Cambridge, England) · 23 Sept 2026 PMID 42775690
  3. Associations between serum lactate and renal dysfunction in diabetic kidney disease: An exploratory analysis integrating animal experiments, clinical cohorts, and bioinformatic approaches. PloS one · 15 Sept 2026 PMID 42743268
  4. Targeting the ChREBP/PKLR-lactate axis via Huachansu tablets restores CD8⁺T cell immunity in MASH-HCC. Pharmacological research · 14 Sept 2026 PMID 42735733
  5. Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytes. Bone research · 27 Aug 2026 PMID 42660868
  6. Polysaccharide Nanocomposite Hydrogel Prevents the Polarity Reversal of β-Glucan-Activated Macrophages by Lactate Oxidase-Based Lactate Depletion for Enhanced Immunotherapy. ACS applied materials & interfaces · 19 Aug 2026 PMID 42615169
  7. Prehospital point-of-care lactate for identification of severe injury in trauma team-activated patients: a prospective multicenter cohort study. European journal of trauma and emergency surgery : official publication of the European Trauma Society · 12 Aug 2026 PMID 42584683
  8. Conformal L012-Gold Nanoparticles/Laser-Induced Graphene Interfaces-Based Flexible Electrochemiluminescence Array for Multiplexed Detection of Sweat Metabolites. Analytical chemistry · 27 Jul 2026 PMID 42503751
  9. Targeting the mechanics-glycolysis-histone lactylation axis to rescue bone regeneration under insufficient mechanical stimulation. Acta biomaterialia · 24 Jul 2026 PMID 42498150
  10. Targeting the NAT1-ENO1-Lactate Axis Destabilizes PD-L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer. MedComm · 23 Jul 2026 PMID 42491336
  11. Missing Lactate Values in Critical Care Registries: A Multiple Imputation Framework for Cardiogenic Shock Research. Journal of clinical epidemiology · 22 Jul 2026 PMID 42486195
  12. Association Between Lactate-to-Albumin Ratio and 28-Day All-Cause Mortality in ICU-Admitted Acute Pancreatitis Patients: Development and Validation of a Machine Learning-Based Predictive Model Integrating Albumin-Corrected Indices. International journal of medical informatics · 8 Jun 2026 PMID 42259120
  13. Targeting the lactate-lactylation-glucose uptake axis: Cryptotanshinone reprograms metabolic-epigenetic crosstalk in gastric cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology · 3 Jun 2026 PMID 42235355
  14. Development of rapid diagnostic kit against sepsis: Barcode-based semi-quantitative measurement of C-reactive protein and lactate. Journal of pharmaceutical and biomedical analysis · 26 May 2026 PMID 42190402
  15. Interfacial impedance engineering in ionic hydrogels for integrated enzymatic and electrophysiological sensing. Biosensors & bioelectronics · 17 May 2026 PMID 42143895

By study type

Observational studies and case reports (2)
  1. Associations between serum lactate and renal dysfunction in diabetic kidney disease: An exploratory analysis integrating animal experiments, clinical cohorts, and bioinformatic approaches. PloS one · 15 Sept 2026 PMID 42743268
  2. Prehospital point-of-care lactate for identification of severe injury in trauma team-activated patients: a prospective multicenter cohort study. European journal of trauma and emergency surgery : official publication of the European Trauma Society · 12 Aug 2026 PMID 42584683
Human data, design not indexed (5)
  1. Plasmon-enhanced molecularly imprinted photoelectrochemical sensor for non-invasive lactate monitoring in sweat. Chemical communications (Cambridge, England) · 23 Sept 2026 PMID 42775690
  2. Conformal L012-Gold Nanoparticles/Laser-Induced Graphene Interfaces-Based Flexible Electrochemiluminescence Array for Multiplexed Detection of Sweat Metabolites. Analytical chemistry · 27 Jul 2026 PMID 42503751
  3. Association Between Lactate-to-Albumin Ratio and 28-Day All-Cause Mortality in ICU-Admitted Acute Pancreatitis Patients: Development and Validation of a Machine Learning-Based Predictive Model Integrating Albumin-Corrected Indices. International journal of medical informatics · 8 Jun 2026 PMID 42259120
  4. Development of rapid diagnostic kit against sepsis: Barcode-based semi-quantitative measurement of C-reactive protein and lactate. Journal of pharmaceutical and biomedical analysis · 26 May 2026 PMID 42190402
  5. Interfacial impedance engineering in ionic hydrogels for integrated enzymatic and electrophysiological sensing. Biosensors & bioelectronics · 17 May 2026 PMID 42143895
Preclinical: animal, cell and lab studies (4)
  1. Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytes. Bone research · 27 Aug 2026 PMID 42660868
  2. Polysaccharide Nanocomposite Hydrogel Prevents the Polarity Reversal of β-Glucan-Activated Macrophages by Lactate Oxidase-Based Lactate Depletion for Enhanced Immunotherapy. ACS applied materials & interfaces · 19 Aug 2026 PMID 42615169
  3. Targeting the mechanics-glycolysis-histone lactylation axis to rescue bone regeneration under insufficient mechanical stimulation. Acta biomaterialia · 24 Jul 2026 PMID 42498150
  4. Targeting the lactate-lactylation-glucose uptake axis: Cryptotanshinone reprograms metabolic-epigenetic crosstalk in gastric cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology · 3 Jun 2026 PMID 42235355
Unclassified: not yet indexed with MeSH (4)
  1. Lactate-Depleting Nanotherapy Reprograms the Immunometabolic Microenvironment to Overcome Biofilm Tolerance in Implant-Associated Infections. Advanced materials (Deerfield Beach, Fla.) · 2 Oct 2026 PMID 42825697
  2. Targeting the ChREBP/PKLR-lactate axis via Huachansu tablets restores CD8⁺T cell immunity in MASH-HCC. Pharmacological research · 14 Sept 2026 PMID 42735733
  3. Targeting the NAT1-ENO1-Lactate Axis Destabilizes PD-L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer. MedComm · 23 Jul 2026 PMID 42491336
  4. Missing Lactate Values in Critical Care Registries: A Multiple Imputation Framework for Cardiogenic Shock Research. Journal of clinical epidemiology · 22 Jul 2026 PMID 42486195
bioLLM/wiki is a literature-navigation aid for people who read primary research. It is not a medical resource, and it is not a substitute for a clinician, a pharmacist or the source papers themselves. Because the articles are drafted by language models, they can be incomplete or wrong in ways that read fluently. Please see the editorial policy and medical disclaimer before relying on anything here.

Written from 15 PubMed abstracts, each one listed by PMID above. Published: 2026-08-21. Last written: 2026-09-17 by GPT. Drafted by language models from published abstracts; not medical advice.