Liposome
A liposome is a lipid-based vesicular nanocarrier consisting of an aqueous compartment enclosed by a lipid bilayer.
A liposome is a lipid-based vesicular nanocarrier consisting of an aqueous compartment enclosed by a lipid bilayer. Its membrane-like architecture and biocompatibility support the encapsulation and transport of both hydrophilic and lipophilic drugs, making liposomes one of the clinically validated nanocarrier platforms for pharmaceutical delivery. Liposome performance is influenced by properties such as particle size, lipid composition, cholesterol content, surface charge, encapsulation efficiency, and membrane stability.
Liposomes can be engineered with surface components that alter their biological interactions. In particular, PEGylated liposomes carry a polyethylene glycol corona whose chain length, surface density, and coating strategy affect stability, circulation lifetime, and interactions with biological systems. Functionalization with aptamers, hyaluronic acid, antibodies, or metallic nanoparticles can be used to modify cellular uptake, tissue distribution, trafficking, or targeting behavior. These properties have placed liposomes within several major areas of biomedical research, including blood–brain barrier drug delivery, cancer gene delivery, cellular uptake and biocompatibility, oxidative stress and inflammation, and the development of systems related to extracellular vesicles and exosomes.
Where the papers sit
9 papers from the last 6 months study liposome directly · updated from PubMed 21 Oct 2026
Study type 0 clinical trials · 2 human data · 7 preclinical
Themes one subject
Those 9 are all about one subject.
-
Advanced Liposome Drug Delivery
Liposome development is moving toward multifunctional, responsive delivery systems rather than simple drug encapsulation. EGFR-degrading PROTACs with calcium peroxide aim to combine tumor targeting with hypoxia relief, while pH-responsive systems co-deliver membrane-active peptides and PI3Kγ inhibitors to remodel the tumor microenvironment. Aptamers, anti-PEG antibodies and β-CMCD coatings address targeting, immune recognition and cellular retention. Supercritical CO2 production and hydrogel formulations extend this work toward scalable manufacturing and tissue repair.
Papers
The 9 papers from the last 6 months that study liposome directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Advanced Liposome Drug Delivery (9)
- EGFR-Degrading PROTACs and Calcium Peroxide Co-loaded Liposomes: Enabling EGFR Degradation and Hypoxia Alleviation as Dual Safeguards for NSCLC Therapy. ACS applied materials & interfaces · 1 Sept 2026 PMID 42679142
- Regulating the membrane-fusion effect of liposomes via the protonation of tertiary amines. Biomaterials science · 25 Aug 2026 PMID 42639698
- pH-Responsive liposomes co-delivering a membrane-active peptide and the PI3Kγ inhibitor to reconstruct the tumor microenvironment for enhanced antitumor immunotherapy. Biomaterials science · 17 Aug 2026 PMID 42605855
- Pilot scale transfer and optimization of an innovative supercritical CO2 PGSS method for the production of drug-encapsulating liposomes. International journal of pharmaceutics · 4 Aug 2026 PMID 42551720
- Anti-PEG Single-Chain Variable-Fragment Antibody-Assisted In Vivo Process Decoding of PEGylated Nanomedicines. ACS nano · 27 Jul 2026 PMID 42503863
- Dual-drug-loaded lipid-based formulation for colon cancer therapeutics: in vitro optimization and characterization. Drug development and industrial pharmacy · 17 Jul 2026 PMID 42467220
- Cooperative membrane retention: How does β-CMCD coating enhance cationic liposome association with cells? Biochemical and biophysical research communications · 16 Jul 2026 PMID 42462459
- Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy. Journal of controlled release : official journal of the Controlled Release Society · 6 Jul 2026 PMID 42409241
- Aptamer-Functionalized Liposome Delivery System Based on Multifunctional Microreactor Design. ACS applied materials & interfaces · 24 Jun 2026 PMID 42339546
By study type
Human data, design not indexed (2)
- Regulating the membrane-fusion effect of liposomes via the protonation of tertiary amines. Biomaterials science · 25 Aug 2026 PMID 42639698
- Dual-drug-loaded lipid-based formulation for colon cancer therapeutics: in vitro optimization and characterization. Drug development and industrial pharmacy · 17 Jul 2026 PMID 42467220
Preclinical: animal, cell and lab studies (7)
- EGFR-Degrading PROTACs and Calcium Peroxide Co-loaded Liposomes: Enabling EGFR Degradation and Hypoxia Alleviation as Dual Safeguards for NSCLC Therapy. ACS applied materials & interfaces · 1 Sept 2026 PMID 42679142
- pH-Responsive liposomes co-delivering a membrane-active peptide and the PI3Kγ inhibitor to reconstruct the tumor microenvironment for enhanced antitumor immunotherapy. Biomaterials science · 17 Aug 2026 PMID 42605855
- Pilot scale transfer and optimization of an innovative supercritical CO2 PGSS method for the production of drug-encapsulating liposomes. International journal of pharmaceutics · 4 Aug 2026 PMID 42551720
- Anti-PEG Single-Chain Variable-Fragment Antibody-Assisted In Vivo Process Decoding of PEGylated Nanomedicines. ACS nano · 27 Jul 2026 PMID 42503863
- Cooperative membrane retention: How does β-CMCD coating enhance cationic liposome association with cells? Biochemical and biophysical research communications · 16 Jul 2026 PMID 42462459
- Asymmetric hydrogel with "spear-shield" properties promotes diabetic foot ulcer healing by modulating macrophage autophagy. Journal of controlled release : official journal of the Controlled Release Society · 6 Jul 2026 PMID 42409241
- Aptamer-Functionalized Liposome Delivery System Based on Multifunctional Microreactor Design. ACS applied materials & interfaces · 24 Jun 2026 PMID 42339546
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-08-22. Last written: 2026-08-27 by GPT. Drafted by language models from published abstracts; not medical advice.