Doxycycline
Doxycycline is a broad-spectrum tetracycline-class antibiotic used in therapy for a range of bacterial infections and inflammatory conditions.
Doxycycline is a broad-spectrum tetracycline-class antibiotic used in therapy for a range of bacterial infections and inflammatory conditions. It acts primarily by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit, which makes it active against many Gram-positive and Gram-negative organisms as well as atypical pathogens. In clinical practice, doxycycline is also valued for its oral bioavailability, tissue penetration, and utility as an alternative when other antibiotics are unsuitable.
Beyond its antimicrobial role, doxycycline is frequently studied as a platform drug in drug-delivery systems and localized formulations. Recent research contexts also reflect interest in its anti-inflammatory and tissue-modulating properties, including applications in periodontal disease and experimental prevention strategies for sexually transmitted infections. Its use in children and in combination regimens continues to be evaluated, particularly where macrolides such as azithromycin are standard comparators.
Where the papers sit
11 papers from the last 6 months study doxycycline directly · updated from PubMed 3 Oct 2026
Study type 1 clinical trial · 1 observational · 2 human data · 5 preclinical · 2 unclassified
Themes 3 themes
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Preclinical Therapeutic Innovation
Local delivery systems and combination therapies are being developed to improve treatment of cancer, acne, and inflammatory disease. Microneedles and nanoparticles aim to concentrate therapy while engaging ROS, NF-κB, or immune pathways. In breast cancer, TBX20-associated doxorubicin resistance recurs through ABCC1 upregulation and suppressed mitophagy. The field remains preclinical, with efficacy and mechanism studied more often than durable clinical outcomes.
4 papers · 36.4%
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Antibiotic Prevention and Treatment
Doxycycline is being tested across sexually transmitted infection prevention, respiratory infection treatment, and opportunistic bacterial disease. Doxycycline post-exposure prophylaxis is gaining attention, while rising Neisseria gonorrhoeae resistance and azithromycin exposure complicate its durability. Formulations combining doxycycline with tenofovir alafenamide and elvitegravir extend prevention research toward localized delivery. Comparative treatment with macrolides for Mycoplasma pneumoniae and infection recognition in rituximab-treated patients remain important clinical questions.
4 papers · 36.4%
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Others — Heterogeneous Biomedical Studies
Long-term cancer survivorship, adenomyosis genetics, and controlled drug release occupy separate lines of investigation. Ewing sarcoma work focuses on late outcomes after historical treatment regimens. Adenomyosis research links exosome-related genes to quantitative-trait and tissue-expression data. Collagen gels provide a platform for sustained doxycycline release, but no shared biological question unites the cluster.
3 papers · 27.3%
Papers
The 11 papers from the last 6 months that study doxycycline directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Preclinical Therapeutic Innovation (4)
- TBX20 promotes doxorubicin resistance in breast cancer cells through enhanced ABCC1 expression and inhibition of mitophagy. PloS one · 17 Jul 2026 PMID 42467708
- Bioorthogonal Catalytic Microneedles Based on a Cytotoxic PEI Matrix for Synergistic Melanoma Therapy. ACS applied materials & interfaces · 30 Jun 2026 PMID 42378371
- Polyphenol-based nanoparticles enhancing doxycycline efficacy for acne therapy. Journal of materials chemistry. B · 26 Jun 2026 PMID 42358218
- Versatile Microneedle Platform for Localized Immunomodulatory Therapy of Periodontitis Targeting the Reactive Oxygen Species/NF-κB Pathway. ACS nano · 20 Apr 2026 PMID 42007801
Antibiotic Prevention and Treatment (4)
- Antimicrobial resistance in Neisseria gonorrhoeae among men who have sex with men: a 10-year analysis with implications for doxycycline post-exposure prophylaxis. Journal of clinical microbiology · 25 Sept 2026 PMID 42788724
- Neoehrlichiosis Causing Hemolytic Anemia in Patients Treated with Rituximab, Norway, 2024-2025. Emerging infectious diseases · 27 Aug 2026 PMID 42660584
- Efficacy and safety of Doxycycline versus Macrolides for Mycoplasma pneumoniae INfectiOn in Children (DOMINO): a protocol for a multicentre, randomised, open-label, superiority trial. BMJ open · 26 May 2026 PMID 42191206
- Formulation Development of Topical Inserts Containing Doxycycline and Doxycycline Combined with Tenofovir Alafenamide and Elvitegravir for the Prevention of Sexually Transmitted Infections. AAPS PharmSciTech · 6 May 2026 PMID 42091755
Others — Heterogeneous Biomedical Studies (3)
- Exosome-Related Pathogenic Genes in Adenomyosis: A Multi-Omics Mendelian Randomization Study. Omics : a journal of integrative biology · 18 Aug 2026 PMID 42610667
- Long-term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970-1999: A report from the Childhood Cancer Survivor Study. Cancer · 2 Jul 2026 PMID 42390889
- Doxycycline release from cyclodextrin oligomer-containing collagen gels. Journal of controlled release : official journal of the Controlled Release Society · 7 May 2026 PMID 42097227
By study type
Clinical trials (1)
- Efficacy and safety of Doxycycline versus Macrolides for Mycoplasma pneumoniae INfectiOn in Children (DOMINO): a protocol for a multicentre, randomised, open-label, superiority trial. BMJ open · 26 May 2026 PMID 42191206
Observational studies and case reports (1)
- Neoehrlichiosis Causing Hemolytic Anemia in Patients Treated with Rituximab, Norway, 2024-2025. Emerging infectious diseases · 27 Aug 2026 PMID 42660584
Human data, design not indexed (2)
- Long-term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970-1999: A report from the Childhood Cancer Survivor Study. Cancer · 2 Jul 2026 PMID 42390889
- Formulation Development of Topical Inserts Containing Doxycycline and Doxycycline Combined with Tenofovir Alafenamide and Elvitegravir for the Prevention of Sexually Transmitted Infections. AAPS PharmSciTech · 6 May 2026 PMID 42091755
Preclinical: animal, cell and lab studies (5)
- TBX20 promotes doxorubicin resistance in breast cancer cells through enhanced ABCC1 expression and inhibition of mitophagy. PloS one · 17 Jul 2026 PMID 42467708
- Bioorthogonal Catalytic Microneedles Based on a Cytotoxic PEI Matrix for Synergistic Melanoma Therapy. ACS applied materials & interfaces · 30 Jun 2026 PMID 42378371
- Polyphenol-based nanoparticles enhancing doxycycline efficacy for acne therapy. Journal of materials chemistry. B · 26 Jun 2026 PMID 42358218
- Doxycycline release from cyclodextrin oligomer-containing collagen gels. Journal of controlled release : official journal of the Controlled Release Society · 7 May 2026 PMID 42097227
- Versatile Microneedle Platform for Localized Immunomodulatory Therapy of Periodontitis Targeting the Reactive Oxygen Species/NF-κB Pathway. ACS nano · 20 Apr 2026 PMID 42007801
Unclassified: not yet indexed with MeSH (2)
- Antimicrobial resistance in Neisseria gonorrhoeae among men who have sex with men: a 10-year analysis with implications for doxycycline post-exposure prophylaxis. Journal of clinical microbiology · 25 Sept 2026 PMID 42788724
- Exosome-Related Pathogenic Genes in Adenomyosis: A Multi-Omics Mendelian Randomization Study. Omics : a journal of integrative biology · 18 Aug 2026 PMID 42610667
Written from 11 PubMed abstracts, each one listed by PMID above. Published: 2026-07-16. Last written: 2026-09-26 by GPT. Drafted by language models from published abstracts; not medical advice.