DL-homocysteine
DL-homocysteine is the racemic form of homocysteine, a sulfur-containing amino acid that occupies a central position in one-carbon metabolism and the methionine cycle.
DL-homocysteine is the racemic form of homocysteine, a sulfur-containing amino acid that occupies a central position in one-carbon metabolism and the methionine cycle. In biomedical research, homocysteine is widely treated as a clinically relevant metabolite because its circulating concentration can reflect disruptions in folate and vitamin B12-dependent pathways, altered methylation capacity, and broader metabolic stress. Elevated homocysteine has been associated in recent studies with cognitive decline, neuronal injury, endocrine-metabolic dysregulation, and other disease states.
Although DL-homocysteine itself is a chemical entity rather than a drug, it is frequently studied as a biomarker and mechanistic target in relation to diseases such as Alzheimer's disease, autism spectrum disorder with TORCH-related central nervous system injury, hepatocellular carcinoma, and vitamin B12 deficiency states. Its biological significance lies in its integration with methionine, folate, and DNA methylation biology, as well as its use as a measurable indicator of metabolic imbalance.
Where the papers sit
9 papers from the last 6 months study DL-homocysteine directly · updated from PubMed 12 Oct 2026
Study type 1 clinical trial · 6 observational · 2 human data
Themes one subject · 1 new direction
Those 9 are all about one subject.
-
Homocysteine in Human Health
Homocysteine is being studied mainly as a circulating biomarker across cardiovascular, renal, neurological, psychiatric and pregnancy-related conditions. Elevated or altered homocysteine, cysteine and methionine levels recur in associations with prognosis, cognitive decline, cardiac electrical abnormalities and neonatal outcomes. Folic acid, resistance training and electroconvulsive therapy represent different attempts to modify or interpret these biochemical patterns. The literature remains clinically exploratory, with no single intervention or mechanism unifying the findings.
Homocysteine becomes a signal-modulating reagent in an ultrasensitive cancer assay
The capillary-SERS sensor for serum homocysteine in hepatocellular carcinoma uses homocysteine not merely as a disease biomarker, prognostic variable, or treatment target, but as an active assay reagent that scavenges free radicals and suppresses nanozyme-driven TMB oxidation, thereby modulating the detection signal. This shifts homocysteine into an analytical reaction role: its presence is converted directly into a measurable SERS attenuation pattern that distinguishes hepatocellular carcinoma samples from healthy controls 42065546May.
Papers
The 9 papers from the last 6 months that study DL-homocysteine directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Homocysteine in Human Health (9)
- Changes in Glutathione and Homocysteine Concentrations in Treatment-Resistant Depression After Electroconvulsive Therapy. Medical science monitor : international medical journal of experimental and clinical research · 10 Sept 2026 PMID 42721112
- Association between plasma homocysteine levels and P-wave dispersion in pediatric patients with hyperhomocysteinemia. European journal of pediatrics · 6 Sept 2026 PMID 42701125
- Predictive value of homocysteine and blood lipid levels in late pregnancy for neonatal outcomes in women with hypertensive disorders of pregnancy. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2 Sept 2026 PMID 42682213
- Effects of folic acid combined with resistance training on body composition and blood biomarkers in adult males. Journal of the International Society of Sports Nutrition · 21 Aug 2026 PMID 42627860
- Homocysteine, cysteine and methionine are associated with 90-day prognosis in intracerebral hemorrhage patients. Annals of medicine · 21 Aug 2026 PMID 42626963
- Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study. Annals of medicine · 18 Aug 2026 PMID 42610309
- Biochemical Predictors in the Blood Serum of Children with TORCH Encephalopathy and Autism. Journal of molecular neuroscience : MN · 29 May 2026 PMID 42213276
- Methionine, Homocysteine, and Methylation Levels Predict Cognitive Decline in Alzheimer's Disease. CNS neuroscience & therapeutics · 27 May 2026 PMID 42201257
- Capillary-SERS sensor based on aptamer-mediated inhibition of nanozyme catalysis for ultrasensitive detection of homocysteine in serum from hepatocellular carcinoma patients. Analytical methods : advancing methods and applications · 1 May 2026 PMID 42065546
By study type
Clinical trials (1)
- Effects of folic acid combined with resistance training on body composition and blood biomarkers in adult males. Journal of the International Society of Sports Nutrition · 21 Aug 2026 PMID 42627860
Observational studies and case reports (6)
- Changes in Glutathione and Homocysteine Concentrations in Treatment-Resistant Depression After Electroconvulsive Therapy. Medical science monitor : international medical journal of experimental and clinical research · 10 Sept 2026 PMID 42721112
- Association between plasma homocysteine levels and P-wave dispersion in pediatric patients with hyperhomocysteinemia. European journal of pediatrics · 6 Sept 2026 PMID 42701125
- Predictive value of homocysteine and blood lipid levels in late pregnancy for neonatal outcomes in women with hypertensive disorders of pregnancy. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2 Sept 2026 PMID 42682213
- Homocysteine, cysteine and methionine are associated with 90-day prognosis in intracerebral hemorrhage patients. Annals of medicine · 21 Aug 2026 PMID 42626963
- Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study. Annals of medicine · 18 Aug 2026 PMID 42610309
- Methionine, Homocysteine, and Methylation Levels Predict Cognitive Decline in Alzheimer's Disease. CNS neuroscience & therapeutics · 27 May 2026 PMID 42201257
Human data, design not indexed (2)
- Biochemical Predictors in the Blood Serum of Children with TORCH Encephalopathy and Autism. Journal of molecular neuroscience : MN · 29 May 2026 PMID 42213276
- Capillary-SERS sensor based on aptamer-mediated inhibition of nanozyme catalysis for ultrasensitive detection of homocysteine in serum from hepatocellular carcinoma patients. Analytical methods : advancing methods and applications · 1 May 2026 PMID 42065546
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-06-15. Last written: 2026-09-12 by GPT. Drafted by language models from published abstracts; not medical advice.