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Bisphenol A

Bisphenol A (BPA; IUPAC name: 4,4'-(propane-2,2-diyl)diphenol) is a synthetic organic compound belonging to the bisphenol chemical family.

Where the papers sit

10 papers from the last 6 months study Bisphenol A directly · updated from PubMed 6 Oct 2026

Study type 0 clinical trials · 1 human data · 5 preclinical · 4 unclassified

Themes 3 themes · 1 new direction

  • Bisphenol a Toxicity Mechanisms

    Oxidative stress, inflammation and metabolic disruption recur across BPA-linked diabetes, airway injury, liver disease and thyroid carcinogenesis. Multi-omics and network toxicology are converging on targets such as NQO1 and the PTEN/PI3K/AKT axis. Immune-microenvironment damage, impaired repair and disulfidptosis extend the mechanisms beyond isolated organ toxicity. The work is moving toward pathway-based biomarkers and targeted protective interventions.

    6 papers · 60%

  • Computational Disease Biomarkers

    Transcriptomic signatures and computational prioritization are being used to connect cell-state changes with clinically relevant disease markers. T-cell depletion and monocyte-associated signals define the lupus analysis, while network and single-cell methods examine BPA-linked clear-cell renal cell carcinoma. Differential expression, machine learning and molecular docking recur as complementary tools. The evidence supports candidate discovery, but validation of diagnostic or prognostic value remains open.

    2 papers · 20%

  • Bisphenol a Detection Technologies

    BPA measurement is shifting toward rapid, portable and multimodal sensing rather than conventional laboratory readouts alone. Smartphone-assisted and spectrophotometric colorimetry use enzymeless nanosensors to improve practical detection. HCR amplification and CRISPR/Cas12a add logic-gate discrimination and dual-analyte capability, with kanamycin included as a target. Detection limits, readout reliability and performance in water or biological specimens remain the key tests.

    2 papers · 20%

NEW DIRECTION

Bisphenol A is presented as a protective treatment rather than a disease-promoting exposure

The murine spinal cord injury model studied in the BPA-treatment paper 42201472May departs from the other abstracts’ use of BPA as an environmental exposure that promotes disease, injury, or cancer. Instead, administering BPA after spinal cord injury improved locomotor recovery and reduced histopathological damage, with associated changes in oxidative-phosphorylation genes and arachidonic-acid metabolites. This gives BPA a distinct therapeutic and neuroprotective role in traumatic injury, rather than its usual pathogenic role in the set.

bisphenol A chemical structure

Papers

The 10 papers from the last 6 months that study Bisphenol A directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.

By theme

Bisphenol a Toxicity Mechanisms (6)
  1. Integrative Multi-Omics Analysis Identifies Key Molecular Targets Linking Bisphenol A Exposure to Gestational Diabetes Mellitus. Reproductive sciences (Thousand Oaks, Calif.) · 5 Aug 2026 PMID 42552472
  2. Integrative multi-omics reveals NQO1-mediated airway epithelial injury as a key mechanism of bisphenol A-induced COPD. Naunyn-Schmiedeberg's archives of pharmacology · 23 Jul 2026 PMID 42489718
  3. Bisphenol A exacerbates diabetic foot ulcers through disruption of immune microenvironment and repair processes: a multi-omics analysis of environmental exposure mechanisms. Drug and chemical toxicology · 15 Jun 2026 PMID 42298305
  4. Mitochondrial-Inflammatory Axis Dysregulation Triggers Disulfidptosis and the Multifaceted Protective Mechanism of Bisphenol A Following Spinal Cord Injury. Molecular neurobiology · 27 May 2026 PMID 42201472
  5. Integrating network toxicology with multi-omics approaches to elucidate molecular targets and pathway mechanisms in BPA-induced hepatocellular carcinoma. Molecular diversity · 12 May 2026 PMID 42118483
  6. Bisphenol A drives thyroid carcinogenesis through oxidative stress-lipid metabolic reprogramming via the PTEN/PI3K/AKT axis: Therapeutic reversal by a curcumin-modified quercetin nanomicelle system. Free radical biology & medicine · 15 Apr 2026 PMID 41985638
Computational Disease Biomarkers (2)
  1. Bioinformatics analysis identifies biomarkers associated with T-cell depletion in systemic lupus erythematosus. Medicine · 30 May 2026 PMID 42216358
  2. Employing network toxicology, molecular docking, machine learning, and single-cell analysis to analyze BPA exposure-induced ccRCC. Biochemical and biophysical research communications · 29 May 2026 PMID 42214919
Bisphenol a Detection Technologies (2)
  1. Dual-readout smartphone-assisted and spectrophotometric colorimetric nanosensor for enzymeless bisphenol A detection. Mikrochimica acta · 5 Oct 2026 PMID 42832064
  2. HCR-assisted CRISPR/Cas12a platform enables logic-gate and multimodal detection of kanamycin and bisphenol A. Analytical methods : advancing methods and applications · 3 Aug 2026 PMID 42544618

By study type

Human data, design not indexed (1)
  1. Bioinformatics analysis identifies biomarkers associated with T-cell depletion in systemic lupus erythematosus. Medicine · 30 May 2026 PMID 42216358
Preclinical: animal, cell and lab studies (5)
  1. Dual-readout smartphone-assisted and spectrophotometric colorimetric nanosensor for enzymeless bisphenol A detection. Mikrochimica acta · 5 Oct 2026 PMID 42832064
  2. HCR-assisted CRISPR/Cas12a platform enables logic-gate and multimodal detection of kanamycin and bisphenol A. Analytical methods : advancing methods and applications · 3 Aug 2026 PMID 42544618
  3. Employing network toxicology, molecular docking, machine learning, and single-cell analysis to analyze BPA exposure-induced ccRCC. Biochemical and biophysical research communications · 29 May 2026 PMID 42214919
  4. Mitochondrial-Inflammatory Axis Dysregulation Triggers Disulfidptosis and the Multifaceted Protective Mechanism of Bisphenol A Following Spinal Cord Injury. Molecular neurobiology · 27 May 2026 PMID 42201472
  5. Bisphenol A drives thyroid carcinogenesis through oxidative stress-lipid metabolic reprogramming via the PTEN/PI3K/AKT axis: Therapeutic reversal by a curcumin-modified quercetin nanomicelle system. Free radical biology & medicine · 15 Apr 2026 PMID 41985638
Unclassified: not yet indexed with MeSH (4)
  1. Integrative Multi-Omics Analysis Identifies Key Molecular Targets Linking Bisphenol A Exposure to Gestational Diabetes Mellitus. Reproductive sciences (Thousand Oaks, Calif.) · 5 Aug 2026 PMID 42552472
  2. Integrative multi-omics reveals NQO1-mediated airway epithelial injury as a key mechanism of bisphenol A-induced COPD. Naunyn-Schmiedeberg's archives of pharmacology · 23 Jul 2026 PMID 42489718
  3. Bisphenol A exacerbates diabetic foot ulcers through disruption of immune microenvironment and repair processes: a multi-omics analysis of environmental exposure mechanisms. Drug and chemical toxicology · 15 Jun 2026 PMID 42298305
  4. Integrating network toxicology with multi-omics approaches to elucidate molecular targets and pathway mechanisms in BPA-induced hepatocellular carcinoma. Molecular diversity · 12 May 2026 PMID 42118483