TGFB1

Where the papers sit

10 papers from the last 6 months study TGFB1 directly · updated from PubMed 12 Oct 2026

• Pulmonary Fibrosis Biology

  Fibroblast activation and macrophage signaling are being connected to extracellular-matrix remodeling in pulmonary fibrosis. Bleomycin models implicate Atg5-dependent autophagy in myofibroblast accumulation and alveolar regeneration, while related fibroblast–macrophage work highlights thrombospondin-1 in fibroinflammatory niches. Therapeutic work is testing rearranged steroids and bispecific CHI3L1/PD-1 targeting. Whether these approaches reverse established fibrosis or mainly limit injury remains open.

  4 papers · 40%

• TGF-β1 Injury Signaling

  Small-molecule and herbal interventions are being evaluated to blunt TGF-β1/Smad-associated injury across diabetic and ocular tissues. Tanshinone IIA, salvianic acid A, salvianolic acid B and hydroxysafflor yellow A reduce cerebral injury, while fermented Astragalus is assessed in diabetic nephropathy. Selpercatinib adds a mechanistically distinct approach by suppressing TGF-β1-induced epithelial–mesenchymal transition in retinal pigment epithelium. The evidence remains preclinical and context-specific, with Smad2/3 signaling and tissue injury as recurring readouts.

  3 papers · 30%

• Others — TGFB1-Linked Tissue Studies

  Cardiac fibrosis, cartilage differentiation and allergic rhinitis are linked here mainly by TGFB1-related signaling, not by a shared disease context. Oleuropein is studied as a modulator of the TGF-β1/Smad pathway in diabetic cardiomyopathy. Separate biomaterial studies use HAMA hydrogels and bioprinting to guide periosteal-cell chondrogenesis, while EGR2 and TGFB1 are explored as allergic-rhinitis biomarkers. The set supports pathway-level investigation but offers no unified therapeutic direction.

  3 papers · 30%