Hydrogen sulfide
Hydrogen sulfide (H₂S) is a small, endogenously produced sulfur-containing gas that functions as a biologically active signaling molecule and, at higher concentrations, a toxic gas.
Hydrogen sulfide (H₂S) is a small, endogenously produced sulfur-containing gas that functions as a biologically active signaling molecule and, at higher concentrations, a toxic gas. In biomedical research it is often discussed as a gasotransmitter alongside nitric oxide and carbon monoxide, with roles in redox regulation, mitochondrial function, inflammation, vascular biology, and cellular stress responses. Its effects are highly context-dependent: physiologic or controlled donor-mediated H₂S exposure can be cytoprotective, whereas excessive environmental exposure is hazardous.
In recent translational studies, hydrogen sulfide has been investigated both as a therapeutic agent and as a mechanistic target. The provided publication contexts show its use in controlled-release donor systems, tumor-responsive nanoplatforms, myocardial repair materials, wound-healing hydrogels, and neuroprotective or mitochondrial-protective interventions. It is also a practical target in industrial biodesulfurization, where microbial systems are used to remove H₂S from natural gas.
Where the papers sit
9 papers from the last 6 months study hydrogen sulfide directly · updated from PubMed 4 Oct 2026
Study type 0 clinical trials · 1 human data · 8 preclinical
Themes one subject · 1 new direction
Those 9 are all about one subject.
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Sulfide Sensing and Therapy
Sulfide-responsive sensing and controlled delivery are being paired with imaging, photodynamic or photoimmunotherapy, tissue repair, and ferroptosis-based treatment. Cardiac and joint disease studies emphasize localized H2S release and pathway modulation, including JAK2/STAT3 and redox mechanisms. Other work develops microbial gas desulfurization or analytical nanoprobes, underscoring technical breadth rather than a single translational trajectory. The shared direction is toward spatially controlled detection or generation, but efficacy and clinical relevance remain unestablished.
Hydrogen sulfide is used as a feedstock for industrial microbial sulfur removal rather than as a biological signal, therapeutic agent, or analytical target
The pilot-scale biodesulfurization of natural gas study treated hydrogen sulfide as a pollutant to be converted by an indigenous microbial community, rapidly enriching sulfur-oxidizing bacteria—especially Thioalkalimicrobium—and producing elemental sulfur as the main product 42261086Jun. This assigns hydrogen sulfide a role outside the set's biological signaling, disease-treatment, and detection applications: it becomes the substrate of an in situ industrial microbiological process, with microbial ecology and sulfur-product structure determining process optimization.
Papers
The 9 papers from the last 6 months that study hydrogen sulfide directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Sulfide Sensing and Therapy (9)
- A naphthalimide based fluorescent liposomal system for sequential copper(II) and hydrogen sulfide detection and its application in hydrogel beads and bioimaging. Dalton transactions (Cambridge, England : 2003) · 17 Jul 2026 PMID 42466947
- "Dual-lock"-controlled activatable nanotheranostics for chemiluminescence resonance energy transfer (CRET)-driven enhanced photoimmunotherapy. Journal of materials chemistry. B · 13 Jul 2026 PMID 42439123
- Sequential H2S-Triggered Redox Relay Nanoprobes for Self-Sustained Chem-Illuminating Cascade Photodynamic Therapy. Angewandte Chemie (International ed. in English) · 7 Jul 2026 PMID 42412407
- An Injectable "Gas-Electro" Bionic Hydrogel for Spatiotemporal Monitoring and Repair of Myocardial Infarction via Sustained H2S Release and Electrophysiological Repair. ACS applied materials & interfaces · 10 Jun 2026 PMID 42265838
- Pilot-scale biodesulfurization of natural gas: microbial ecology and community dynamics of an in situ enriched system. Journal of applied microbiology · 9 Jun 2026 PMID 42261086
- Network pharmacology and experimental validation reveal inhibition of the JAK2/STAT3 pathway by hydrogen sulfide in diabetic cardiomyopathy. International immunopharmacology · 8 Jun 2026 PMID 42259239
- An Engineered Microbial Nanohybrid for Enhanced Ferroptosis Immunotherapy via Hypoxia-Responsive Hydrogen Sulfide Generation and Mitophagy Inhibition. ACS nano · 5 Jun 2026 PMID 42246518
- Antibiotic-free control of infectious osteoarthritis by ROS-responsive hydrogen sulfide nanodepots. Acta biomaterialia · 22 May 2026 PMID 42173463
- Target-Induced Tandem Built-In Electric Fields in the Hollow SnS2/ZIS@ZnS Heterojunction for the Photoelectrochemical Immunoassay. Analytical chemistry · 22 Apr 2026 PMID 42018287
By study type
Human data, design not indexed (1)
- Target-Induced Tandem Built-In Electric Fields in the Hollow SnS2/ZIS@ZnS Heterojunction for the Photoelectrochemical Immunoassay. Analytical chemistry · 22 Apr 2026 PMID 42018287
Preclinical: animal, cell and lab studies (8)
- A naphthalimide based fluorescent liposomal system for sequential copper(II) and hydrogen sulfide detection and its application in hydrogel beads and bioimaging. Dalton transactions (Cambridge, England : 2003) · 17 Jul 2026 PMID 42466947
- "Dual-lock"-controlled activatable nanotheranostics for chemiluminescence resonance energy transfer (CRET)-driven enhanced photoimmunotherapy. Journal of materials chemistry. B · 13 Jul 2026 PMID 42439123
- Sequential H2S-Triggered Redox Relay Nanoprobes for Self-Sustained Chem-Illuminating Cascade Photodynamic Therapy. Angewandte Chemie (International ed. in English) · 7 Jul 2026 PMID 42412407
- An Injectable "Gas-Electro" Bionic Hydrogel for Spatiotemporal Monitoring and Repair of Myocardial Infarction via Sustained H2S Release and Electrophysiological Repair. ACS applied materials & interfaces · 10 Jun 2026 PMID 42265838
- Pilot-scale biodesulfurization of natural gas: microbial ecology and community dynamics of an in situ enriched system. Journal of applied microbiology · 9 Jun 2026 PMID 42261086
- Network pharmacology and experimental validation reveal inhibition of the JAK2/STAT3 pathway by hydrogen sulfide in diabetic cardiomyopathy. International immunopharmacology · 8 Jun 2026 PMID 42259239
- An Engineered Microbial Nanohybrid for Enhanced Ferroptosis Immunotherapy via Hypoxia-Responsive Hydrogen Sulfide Generation and Mitophagy Inhibition. ACS nano · 5 Jun 2026 PMID 42246518
- Antibiotic-free control of infectious osteoarthritis by ROS-responsive hydrogen sulfide nanodepots. Acta biomaterialia · 22 May 2026 PMID 42173463
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-07-01. Last written: 2026-08-27 by GPT. Drafted by language models from published abstracts; not medical advice.