Glucose oxidase (GOD)
Glucose oxidase (GOx, also written GOX or GOD) is a flavoprotein enzyme that catalyzes the oxidation of glucose to D-gluconic acid with the concomitant production of hydrogen peroxide.
Glucose oxidase (GOx, also written GOX or GOD) is a flavoprotein enzyme that catalyzes the oxidation of glucose to D-gluconic acid with the concomitant production of hydrogen peroxide. Because this reaction is highly specific for glucose and generates measurable chemical outputs, glucose oxidase is widely used in biosensing, diagnostic assays, and glucose-responsive therapeutic systems. In biomedical research, it is especially valued as a catalytic component that can amplify signals or trigger downstream reactions through hydrogen peroxide generation and local acidification.
Beyond its analytical role, glucose oxidase is also used as a functional therapeutic enzyme in engineered delivery systems. Recent studies have explored its encapsulation in nanomaterials, metal-organic frameworks, silica nanocapsules, and polymer matrices to improve stability, enable cascade reactions, and support applications in wound healing, cancer therapy, and point-of-care diagnostics. Its activity is often paired with horseradish peroxidase, iron-based materials, or other catalytic components to create self-amplifying or cascade enzyme systems.
Where the papers sit
9 papers from the last 6 months study Glucose oxidase (GOD) directly · updated from PubMed 6 Oct 2026
Study type 0 clinical trials · 9 preclinical
Themes one subject
Those 9 are all about one subject.
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Glucose Oxidase Applications
Engineered glucose oxidase platforms are being applied across responsive drug delivery, infected-wound treatment, cancer therapy and biosensing. Recurring designs exploit glucose depletion and hydrogen peroxide generation for antimicrobial effects, immunogenic cell death and metabolic stress. Microparticles, hydrogels, microneedles and nanoconfined enzyme cascades aim to improve localization, stability and controlled activation. The cluster remains broad, with no single clinical direction established.
Papers
The 9 papers from the last 6 months that study Glucose oxidase (GOD) directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Glucose Oxidase Applications (9)
- Microfluidic-engineered glucose-responsive microparticle depot for smart insulin delivery. Drug delivery · 3 Sept 2026 PMID 42691154
- Efficient Antimicrobial Nanoenzymatic Functionalized Hydrogels for Diabetic Infected Wound Treatment. ACS biomaterials science & engineering · 6 Aug 2026 PMID 42561045
- Targeted intracellular glucose oxidase nanotherapy enables single-dose treatment of prostate cancer. International journal of pharmaceutics · 13 Jul 2026 PMID 42442513
- A TIGIT nanotrapping-guided STING-activatable immunometabolic strategy overcomes innate immune silence and T cell exhaustion in breast cancer. Journal of controlled release : official journal of the Controlled Release Society · 18 Jun 2026 PMID 42314987
- Enhanced Enzyme Cascade Reactions Through Coencapsulation in Biocompatible Silica Nanoconfinement. Chembiochem : a European journal of chemical biology · 26 May 2026 PMID 42186874
- Biomineralization nanozyme-based biodegradable microneedle for accelerating bacteria-infected diabetic wound healing. Mikrochimica acta · 21 May 2026 PMID 42168679
- pH-regulated ''ON/OFF″ glucose oxidase nanoparticles for synergistic therapy and amplification of immunogenic cell death. Free radical biology & medicine · 9 May 2026 PMID 42105793
- Metabolic PANoptosis orchestrated by porous silkworm-like PtFeCoTeMn high-entropy nanozyme for synergistic cancer therapy. Journal of colloid and interface science · 23 Apr 2026 PMID 42025037
- Single-Step Aerosol-Assisted Plasma Deposition of Biocomposite Glucose Oxidase/Poly(ethylene oxide) Films for Biosensing Applications. ACS applied materials & interfaces · 23 Apr 2026 PMID 42021452
By study type
Preclinical: animal, cell and lab studies (9)
- Microfluidic-engineered glucose-responsive microparticle depot for smart insulin delivery. Drug delivery · 3 Sept 2026 PMID 42691154
- Efficient Antimicrobial Nanoenzymatic Functionalized Hydrogels for Diabetic Infected Wound Treatment. ACS biomaterials science & engineering · 6 Aug 2026 PMID 42561045
- Targeted intracellular glucose oxidase nanotherapy enables single-dose treatment of prostate cancer. International journal of pharmaceutics · 13 Jul 2026 PMID 42442513
- A TIGIT nanotrapping-guided STING-activatable immunometabolic strategy overcomes innate immune silence and T cell exhaustion in breast cancer. Journal of controlled release : official journal of the Controlled Release Society · 18 Jun 2026 PMID 42314987
- Enhanced Enzyme Cascade Reactions Through Coencapsulation in Biocompatible Silica Nanoconfinement. Chembiochem : a European journal of chemical biology · 26 May 2026 PMID 42186874
- Biomineralization nanozyme-based biodegradable microneedle for accelerating bacteria-infected diabetic wound healing. Mikrochimica acta · 21 May 2026 PMID 42168679
- pH-regulated ''ON/OFF″ glucose oxidase nanoparticles for synergistic therapy and amplification of immunogenic cell death. Free radical biology & medicine · 9 May 2026 PMID 42105793
- Metabolic PANoptosis orchestrated by porous silkworm-like PtFeCoTeMn high-entropy nanozyme for synergistic cancer therapy. Journal of colloid and interface science · 23 Apr 2026 PMID 42025037
- Single-Step Aerosol-Assisted Plasma Deposition of Biocomposite Glucose Oxidase/Poly(ethylene oxide) Films for Biosensing Applications. ACS applied materials & interfaces · 23 Apr 2026 PMID 42021452
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-06-15. Last written: 2026-07-29 by GPT. Drafted by language models from published abstracts; not medical advice.