D-dimer
D-dimer is a fibrin degradation product formed when cross-linked fibrin is broken down by plasmin during fibrinolysis.
D-dimer is a fibrin degradation product formed when cross-linked fibrin is broken down by plasmin during fibrinolysis. Clinically, it is used as a biomarker of coagulation activation and clot turnover, reflecting the presence of recent or ongoing thrombosis, disseminated intravascular coagulation, severe inflammation, and other states associated with increased fibrin formation and breakdown. Because it is generated only after factor XIII-mediated fibrin cross-linking and subsequent fibrinolysis, D-dimer is more specific for intravascular clot formation than fibrinogen alone, although it is not specific for any single disease.
In routine medicine, D-dimer is most often used in the evaluation of venous thromboembolism, including deep vein thrombosis and pulmonary embolism, and it is also studied in systemic lupus erythematosus, COVID-19, trauma, infection, malignancy, and other prothrombotic or inflammatory conditions. In these settings, D-dimer is typically interpreted alongside other coagulation and inflammation markers such as fibrinogen, thrombomodulin, thrombin-antithrombin complex, tissue plasminogen activator-inhibitor complex, C-reactive protein, ferritin, and prothrombin parameters. Elevated levels may indicate thrombotic risk, disease severity, or poor prognosis, but clinical interpretation depends strongly on the underlying context.
Where the papers sit
12 papers from the last 6 months study d-dimer directly · updated from PubMed 10 Oct 2026
Study type 1 clinical trial · 5 observational · 6 human data
Themes one subject
Those 12 are all about one subject.
-
Coagulation Biomarkers and Risk
D-dimer and related coagulation markers recur as indicators of thrombotic or bleeding risk in trauma, heart failure, COVID-19, acute myeloid leukemia, and critical illness. In severe trauma, serial platelet, fibrinogen, and D-dimer trajectories are assessed for venous thromboembolism and hemorrhagic progression, while COVID-19 studies link them to severity and oxygen needs. The field is moving toward multiplex assays, plasma proteomics, and explainable models combining coagulation with inflammatory markers. Clinical utility remains context-dependent, spanning prognosis, graft viability, infection prediction, and anticoagulant comparisons rather than one shared endpoint.
Papers
The 12 papers from the last 6 months that study d-dimer directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Coagulation Biomarkers and Risk (12)
- Association of D-dimer, fibrin degradation products, and coagulation parameters with progressive hemorrhagic injury following traumatic brain injury: A retrospective cohort study. Medicine · 9 Oct 2026 PMID 42854043
- The relationship between D-dimer and the risk for adverse outcomes in patients with heart failure. Laboratory medicine · 5 Oct 2026 PMID 42832500
- Perfusate Flavin Mononucleotide and D-Dimer as Viability Biomarkers in Australasia's First Hypothermic Machine Perfusion Programme for Liver Transplantation. Clinical transplantation · 1 Oct 2026 PMID 42817598
- An Integrated Cartridge-Based Multiplex Chemiluminescent Immunosensor Platform for the Simultaneous Quantification of Five Coagulation and Fibrinolysis Biomarkers. Analytical chemistry · 11 Aug 2026 PMID 42578868
- An explainable machine learning model for predicting in-hospital infection in patients with systemic lupus erythematosus. Renal failure · 5 Aug 2026 PMID 42557059
- Von Willebrand, factor VIII, and D-dimer levels as predictors of risk and clinical outcomes in acute myeloid leukemia. Clinical and experimental medicine · 20 Jul 2026 PMID 42474591
- Association between lactate dehydrogenase-to-albumin ratio and oxygen therapy requirement in hospitalized patients with COVID-19: A retrospective observational study. Medicine · 18 Jul 2026 PMID 42470040
- Multiplexed Sepsis Immunosorbent Assay Based on Flower-like CoFe2O4/MoS2 with Dual Substrate Affinity. Analytical chemistry · 26 Jun 2026 PMID 42360892
- Plasma proteomics reveal SERPINA1 and CD59 as candidate biomarkers for COVID-19 severity stratification and prognosis prediction. Annals of medicine · 21 Jun 2026 PMID 42323884
- The Trajectories of Platelet, Fibrinogen, and D-dimer in Severe Trauma Patients and Their Value in Predicting Venous Thromboembolism: A Retrospective Study. Dimensions of critical care nursing : DCCN · 28 May 2026 PMID 42207594
- Comparison of aspirin and rivaroxaban for the prevention of pulmonary embolism and deep vein thrombosis in high thrombotic risk patients with systemic lupus erythematosus: study protocol for a multicentre, prospective, randomised controlled trial. Lupus science & medicine · 20 May 2026 PMID 42161432
- Cross-talk between inflammation and coagulation in severe COVID-19: Association of leptin and classical pro-inflammatory markers with coagulation disorders in a single-center observational cohort study. Medicine · 1 May 2026 PMID 42065184
By study type
Clinical trials (1)
- Comparison of aspirin and rivaroxaban for the prevention of pulmonary embolism and deep vein thrombosis in high thrombotic risk patients with systemic lupus erythematosus: study protocol for a multicentre, prospective, randomised controlled trial. Lupus science & medicine · 20 May 2026 PMID 42161432
Observational studies and case reports (5)
- Association of D-dimer, fibrin degradation products, and coagulation parameters with progressive hemorrhagic injury following traumatic brain injury: A retrospective cohort study. Medicine · 9 Oct 2026 PMID 42854043
- Perfusate Flavin Mononucleotide and D-Dimer as Viability Biomarkers in Australasia's First Hypothermic Machine Perfusion Programme for Liver Transplantation. Clinical transplantation · 1 Oct 2026 PMID 42817598
- Association between lactate dehydrogenase-to-albumin ratio and oxygen therapy requirement in hospitalized patients with COVID-19: A retrospective observational study. Medicine · 18 Jul 2026 PMID 42470040
- The Trajectories of Platelet, Fibrinogen, and D-dimer in Severe Trauma Patients and Their Value in Predicting Venous Thromboembolism: A Retrospective Study. Dimensions of critical care nursing : DCCN · 28 May 2026 PMID 42207594
- Cross-talk between inflammation and coagulation in severe COVID-19: Association of leptin and classical pro-inflammatory markers with coagulation disorders in a single-center observational cohort study. Medicine · 1 May 2026 PMID 42065184
Human data, design not indexed (6)
- The relationship between D-dimer and the risk for adverse outcomes in patients with heart failure. Laboratory medicine · 5 Oct 2026 PMID 42832500
- An Integrated Cartridge-Based Multiplex Chemiluminescent Immunosensor Platform for the Simultaneous Quantification of Five Coagulation and Fibrinolysis Biomarkers. Analytical chemistry · 11 Aug 2026 PMID 42578868
- An explainable machine learning model for predicting in-hospital infection in patients with systemic lupus erythematosus. Renal failure · 5 Aug 2026 PMID 42557059
- Von Willebrand, factor VIII, and D-dimer levels as predictors of risk and clinical outcomes in acute myeloid leukemia. Clinical and experimental medicine · 20 Jul 2026 PMID 42474591
- Multiplexed Sepsis Immunosorbent Assay Based on Flower-like CoFe2O4/MoS2 with Dual Substrate Affinity. Analytical chemistry · 26 Jun 2026 PMID 42360892
- Plasma proteomics reveal SERPINA1 and CD59 as candidate biomarkers for COVID-19 severity stratification and prognosis prediction. Annals of medicine · 21 Jun 2026 PMID 42323884
Written from 12 PubMed abstracts, each one listed by PMID above. Published: 2026-08-13. Last written: 2026-08-27 by GPT. Drafted by language models from published abstracts; not medical advice.