Celastrol

Where the papers sit

9 papers from the last 6 months study celastrol directly · updated from PubMed 3 Nov 2026

• Inflammation and Metabolic Injury

  Targeted celastrol delivery is being paired with control of oxidative stress and inflammatory metabolism across liver, gut, kidney and brain injury. Oral polysaccharide assemblies and ginger exosome-like nanoparticles aim to cross intestinal barriers, while macrophage-membrane liposomes enable ROS-responsive release in acute kidney injury. In steatohepatitis, sinusoidal endothelial USP12/CD36 signaling links celastrol to lipid handling and macrophage-driven inflammation. Multi-omics and microbiome profiling in Alzheimer’s disease broaden the work toward system-level mechanisms, but the disease contexts remain diverse.

  5 papers · 55.6%

• Ferroptosis in Rheumatoid Arthritis

  Rheumatoid arthritis research is moving from symptomatic anti-inflammatory effects toward defined synovial targets and regulated cell-death pathways. FGFR1 is implicated in limiting synovial inflammation and joint destruction, while PTGS2-associated ferroptosis resistance in fibroblast-like synoviocytes provides a second mechanistic axis. Collagen-induced arthritis models support reductions in synovitis and structural damage. Whether these targets translate into durable disease modification in human arthritis remains open.

  2 papers · 22.2%

• Oxidative Therapy in Breast Cancer

  Triple-negative breast cancer work is combining celastrol’s oxidative stress effects with immune-checkpoint and growth-signaling control. Copper-doped Prussian blue nanoparticle hydrogels amplify oxidative stress and support multimodal treatment in tumor-bearing mice. A separate mechanism study links reduced TNBC proliferation and immune escape to the LKB1-AMPK-PD-L1/MYC axis. The field is moving toward integrated cytotoxic and immune-sensitizing strategies, but evidence remains preclinical.

  2 papers · 22.2%