Acute kidney injury
Acute kidney injury (AKI) is a rapid deterioration in kidney function that can impair glomerular filtration and disturb fluid, electrolyte, and metabolic homeostasis.
Acute kidney injury (AKI) is a rapid deterioration in kidney function that can impair glomerular filtration and disturb fluid, electrolyte, and metabolic homeostasis. It is commonly evaluated using changes in serum creatinine level, estimated glomerular filtration rate, urine output, and related markers such as proteinuria or urine albumin-to-creatinine ratio. AKI may occur in association with sepsis, diabetes, rhabdomyolysis, surgery, transplantation, drug exposure, or renal ischemia-reperfusion injury.
The publication contexts supplied here examine AKI as both a clinical outcome and a biologically heterogeneous syndrome. The mechanisms under investigation include altered hemodynamics, endothelial dysfunction, inflammation, oxidative stress, reactive oxygen species, mitochondrial injury, apoptosis, and ferroptosis. Experimental work has also explored whether mesenchymal stem/stromal cells and mitochondrial transfer can modify the oxidative stress–inflammation axis, while clinical studies have focused on risk prediction using albuminuria, perioperative variables, machine learning, and adverse-event databases.
Where the papers sit
10 papers from the last 6 months study acute kidney injury directly · updated from PubMed 3 Nov 2026
Study type 0 clinical trials · 7 observational · 1 human data · 2 preclinical
Themes one subject
Those 10 are all about one subject.
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Clinical Acute Kidney Injury Research
Risk stratification and early detection dominate, spanning plasma VGF, urine albumin-to-creatinine ratio, hemodynamic indices and machine-learning models. Perioperative surgery, cardiac bypass, transplantation, rhabdomyolysis and hyperchloremia recur as clinical settings or exposures. Mechanistic studies point to endothelial dysfunction, mitochondrial transfer, PGC1α and oxidative inflammation, while sildenafil and stem-cell approaches suggest prevention. The cluster remains clinically broad, with no single intervention or predictive marker established across settings.
Papers
The 10 papers from the last 6 months that study acute kidney injury directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Clinical Acute Kidney Injury Research (10)
- Plasma VGF as a Predictive Biomarker for Early Acute Kidney Injury in Critically Ill Elderly Patients: A Combined Clinical and Mendelian Randomization Study. Saudi medical journal · 19 Sept 2026 PMID 42761708
- Preoperative Urine Albumin-to-Creatinine Ratio Predicts Acute Kidney Injury After Coronary Artery Bypass Grafting. Saudi medical journal · 14 Aug 2026 PMID 42598516
- Delayed conception or sildenafil prevents endothelial dysfunction in pregnant rats after renal ischemia-reperfusion. American journal of physiology. Renal physiology · 30 Jul 2026 PMID 42530300
- Connexin 43-dependent mesenchymal stem cell mitochondrial transfer activates PGC1α disrupting oxidative-inflammation axis in ischemia-reperfusion injury. Signal transduction and targeted therapy · 20 Jul 2026 PMID 42476966
- Exploring Risks of Adverse Drug Events From Single Drug to Three-Drug Combination. Clinical and translational science · 18 Jul 2026 PMID 42471477
- Acute kidney injury in rhabdomyolysis defined by serum creatine kinase ≥1000 IU/L: association with creatine kinase levels. Postgraduate medical journal · 13 Jun 2026 PMID 42287721
- Predictive accuracy of a perioperative hemodynamic indices-based prediction model for moderate-to-severe acute kidney injury after orthotopic heart transplantation. Surgery · 9 Jun 2026 PMID 42264774
- Perioperative hyperchloremia is associated with acute kidney injury in elderly patients undergoing bipolar plasmakinetic transurethral resection of the prostate: a prospective observational study. World journal of urology · 26 May 2026 PMID 42189243
- Early Acute Kidney Injury in Allogeneic Hematopoietic Cell Transplantation: Incidence, Severity, and Associated Factors in a 634-Recipient Cohort. European journal of haematology · 21 May 2026 PMID 42167927
- Machine learning-based risk prediction model for postoperative acute kidney injury in surgical patients with chronic kidney disease (CKD): development, validation, and SHAP-based explainability. Renal failure · 20 May 2026 PMID 42157597
By study type
Observational studies and case reports (7)
- Plasma VGF as a Predictive Biomarker for Early Acute Kidney Injury in Critically Ill Elderly Patients: A Combined Clinical and Mendelian Randomization Study. Saudi medical journal · 19 Sept 2026 PMID 42761708
- Preoperative Urine Albumin-to-Creatinine Ratio Predicts Acute Kidney Injury After Coronary Artery Bypass Grafting. Saudi medical journal · 14 Aug 2026 PMID 42598516
- Exploring Risks of Adverse Drug Events From Single Drug to Three-Drug Combination. Clinical and translational science · 18 Jul 2026 PMID 42471477
- Acute kidney injury in rhabdomyolysis defined by serum creatine kinase ≥1000 IU/L: association with creatine kinase levels. Postgraduate medical journal · 13 Jun 2026 PMID 42287721
- Predictive accuracy of a perioperative hemodynamic indices-based prediction model for moderate-to-severe acute kidney injury after orthotopic heart transplantation. Surgery · 9 Jun 2026 PMID 42264774
- Perioperative hyperchloremia is associated with acute kidney injury in elderly patients undergoing bipolar plasmakinetic transurethral resection of the prostate: a prospective observational study. World journal of urology · 26 May 2026 PMID 42189243
- Early Acute Kidney Injury in Allogeneic Hematopoietic Cell Transplantation: Incidence, Severity, and Associated Factors in a 634-Recipient Cohort. European journal of haematology · 21 May 2026 PMID 42167927
Human data, design not indexed (1)
- Machine learning-based risk prediction model for postoperative acute kidney injury in surgical patients with chronic kidney disease (CKD): development, validation, and SHAP-based explainability. Renal failure · 20 May 2026 PMID 42157597
Preclinical: animal, cell and lab studies (2)
- Delayed conception or sildenafil prevents endothelial dysfunction in pregnant rats after renal ischemia-reperfusion. American journal of physiology. Renal physiology · 30 Jul 2026 PMID 42530300
- Connexin 43-dependent mesenchymal stem cell mitochondrial transfer activates PGC1α disrupting oxidative-inflammation axis in ischemia-reperfusion injury. Signal transduction and targeted therapy · 20 Jul 2026 PMID 42476966
Written from 10 PubMed abstracts, each one listed by PMID above. Published: 2026-09-02. Drafted by language models from published abstracts; not medical advice.