Salivary cortisol

Where the papers sit

10 papers from the last 6 months study salivary cortisol directly · updated from PubMed 5 Oct 2026

• Adrenal Insufficiency Management

  Adrenal insufficiency work is shifting toward better identification of stress-related cortisol deficiency and more tailored steroid replacement. Hydrocortisone, with or without fludrocortisone, is being tested in prednisolone-induced insufficiency and critical illness-related corticosteroid insufficiency. Refractory hyponatremia, especially after brain injury or pituitary surgery, remains a recurring clinical clue, but hypocortisolism explains only some postoperative cases. Multicentre protocols and biomarker-enrichment strategies aim to clarify CIRCI criteria and treatment benefit.

  4 papers · 40%

• Cortisol Sensor Development

  Wearable and point-of-care platforms are moving cortisol measurement toward continuous, real-time monitoring in sweat and other complex matrices. Molecularly imprinted polymers, aptamers, SERS, and electrochemical or fluorescent readouts recur as routes to higher sensitivity and selectivity. Gold and Prussian blue nanostructures expand detection range, while time-gated fluorescence addresses autofluorescence. Translation still hinges on stable operation and validation against clinical cortisol measurements.

  3 papers · 30%

• Others — Cortisol Biomarker Validation

  Cortisol biomarker measurement spans hair, peri-implant crevicular fluid, and urine, with assay validation central to interpretation. Chromogranin A, S100A12, dehydroepiandrosterone, and psychometric measures appear as accompanying indicators of stress, health, or disease. Urinary-free cortisol thresholds are being assessed for distinguishing ACTH-dependent Cushing syndrome, while other work focuses on biomarker changes across physiological or production stages. The cluster shares an emphasis on measurement validity but lacks a single clinical application or unified direction.

  3 papers · 30%