Mitogen-activated protein kinase 8 (MAPK8)
Mitogen-activated protein kinase 8 (MAPK8), commonly known as c-Jun N-terminal kinase 1 (JNK1), is a stress-responsive mitogen-activated protein kinase investigated as a regulator of inflammation, apoptosis, cellular stress responses, and epithelial–mesenchymal transition (EMT).
Mitogen-activated protein kinase 8 (MAPK8), commonly known as c-Jun N-terminal kinase 1 (JNK1), is a stress-responsive mitogen-activated protein kinase investigated as a regulator of inflammation, apoptosis, cellular stress responses, and epithelial–mesenchymal transition (EMT). In the studies summarized here, MAPK8/JNK1 appears within signaling networks involving NF-κB, p53, reactive oxygen species (ROS), transforming growth factor beta (TGF-β), and EGFR/SRC-mediated EMT. These associations place MAPK8 at the intersection of inflammatory signaling, cell-survival decisions, and tissue-remodeling processes.
MAPK8 has been examined both as a mechanistic readout and as a potential pharmacological target. Reported approaches include pathway inhibition, molecular docking and molecular dynamics, network-pharmacology target prediction, exosome-based intervention, and the design of hydrophobic-tag degraders. The supplied literature particularly extends themes of inflammation and apoptosis, airway inflammation and T-cell biology, and EGFR/SRC-mediated EMT. Related entities appearing in these contexts include NF-κB, caspase-3, BAX, BCL2 apoptosis regulator, endoplasmic reticulum stress, the unfolded protein response, ERN1, glucose-regulated protein 78, and oxidative stress.
Where the papers sit
9 papers from the last 6 months study Mitogen-activated protein kinase 8 (MAPK8) directly · updated from PubMed 14 Oct 2026
Study type 0 clinical trials · 2 human data · 5 preclinical · 2 unclassified
Themes one subject
Those 9 are all about one subject.
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JNK Signaling in Disease
JNK/MAPK8 signaling is treated as a stress-response hub linking inflammation, apoptosis, immune differentiation and epithelial–mesenchymal transition. Natural products and other small molecules modulate JNK alongside NF-κB, p53, ROS and unfolded-protein-response pathways in models of cancer, allergy, neurodegeneration and tissue injury. JNK1-directed PROTACs extend this approach toward targeted protein degradation and anti-EMT activity. Recurring endpoints are reduced inflammatory signaling, oxidative damage and cell death, but clinical translation remains open.
Papers
The 9 papers from the last 6 months that study Mitogen-activated protein kinase 8 (MAPK8) directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
JNK Signaling in Disease (9)
- Quercetin attenuates emamectin benzoate-induced myocardial PANoptosis in chickens: Critical role of the MAPK/NF-κB signaling pathway and mitochondrial dynamics. International immunopharmacology · 5 Sept 2026 PMID 42700512
- Novel VHL ligand-based PROTACs targeting JNK1: design, synthesis, and biological evaluation with potent anti-EMT activity. Bioorganic chemistry · 18 Aug 2026 PMID 42612267
- α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model. International journal of molecular medicine · 14 Aug 2026 PMID 42596835
- JNK and p53 cause human and mouse β cell death during excessive unfolded protein response. The Journal of clinical investigation · 3 Aug 2026 PMID 42544575
- Unveiling Large-Scale Kinase-Centric Protein-Protein Interactions through a Knowledge-Informed Workflow. Journal of chemical information and modeling · 10 Jul 2026 PMID 42427025
- Multi-omics combined analysis of turmeric volatile oil alleviating allergic rhinitis through the JNK/MAPK-Relb/NF-κB pathway. NPJ science of food · 17 Jun 2026 PMID 42310315
- Santamarine Synergizes With Cisplatin via ROS/JNK Axis to Selectively Induce Apoptosis and DNA Damage in Oral Cancer Cells In Vitro. Drug development research · 26 May 2026 PMID 42187533
- Multitarget pharmacological effects of Lawsone in mitigating Alzheimer's disease. European journal of pharmacology · 9 May 2026 PMID 42105996
- Integrated UPLC-QTOF-MS and Network Pharmacology for Predicting Active Constituents and Pharmacological Mechanisms of Yinxingye Tablets Against Oxidative Stress. Biomedical chromatography : BMC · 9 May 2026 PMID 42104588
By study type
Human data, design not indexed (2)
- Novel VHL ligand-based PROTACs targeting JNK1: design, synthesis, and biological evaluation with potent anti-EMT activity. Bioorganic chemistry · 18 Aug 2026 PMID 42612267
- Unveiling Large-Scale Kinase-Centric Protein-Protein Interactions through a Knowledge-Informed Workflow. Journal of chemical information and modeling · 10 Jul 2026 PMID 42427025
Preclinical: animal, cell and lab studies (5)
- α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model. International journal of molecular medicine · 14 Aug 2026 PMID 42596835
- JNK and p53 cause human and mouse β cell death during excessive unfolded protein response. The Journal of clinical investigation · 3 Aug 2026 PMID 42544575
- Santamarine Synergizes With Cisplatin via ROS/JNK Axis to Selectively Induce Apoptosis and DNA Damage in Oral Cancer Cells In Vitro. Drug development research · 26 May 2026 PMID 42187533
- Multitarget pharmacological effects of Lawsone in mitigating Alzheimer's disease. European journal of pharmacology · 9 May 2026 PMID 42105996
- Integrated UPLC-QTOF-MS and Network Pharmacology for Predicting Active Constituents and Pharmacological Mechanisms of Yinxingye Tablets Against Oxidative Stress. Biomedical chromatography : BMC · 9 May 2026 PMID 42104588
Unclassified: not yet indexed with MeSH (2)
- Quercetin attenuates emamectin benzoate-induced myocardial PANoptosis in chickens: Critical role of the MAPK/NF-κB signaling pathway and mitochondrial dynamics. International immunopharmacology · 5 Sept 2026 PMID 42700512
- Multi-omics combined analysis of turmeric volatile oil alleviating allergic rhinitis through the JNK/MAPK-Relb/NF-κB pathway. NPJ science of food · 17 Jun 2026 PMID 42310315
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-09-06. Last written: 2026-09-07 by GPT. Drafted by language models from published abstracts; not medical advice.