Mitochondrial respiratory chain complex I
Mitochondrial respiratory chain complex I, also known as NADH:ubiquinone oxidoreductase, is the first and one of the largest enzyme complexes of the mitochondrial oxidative phosphorylation system.
Mitochondrial respiratory chain complex I, also known as NADH:ubiquinone oxidoreductase, is the first and one of the largest enzyme complexes of the mitochondrial oxidative phosphorylation system. It catalyzes electron transfer from NADH to ubiquinone and contributes to the proton gradient that drives ATP synthesis. Because of this central role in mitochondrial bioenergetics, complex I is a major determinant of cellular energy production, redox balance, and susceptibility to oxidative stress.
In biomedical research, complex I is frequently studied as both a functional readout of mitochondrial health and a therapeutic target. Altered complex I activity has been linked in the provided studies to renal fibrosis, neurodegeneration, endocrine resistance in breast cancer, immunotherapy response in esophageal squamous cell carcinoma, pediatric acute myeloid leukemia, and mitochondrial dysfunction in immune cells. The entity is also relevant in plant biology, where disruption of mitochondrial complex I-related pathways can affect growth and development.
Where the papers sit
9 papers from the last 6 months study Mitochondrial respiratory chain complex I directly · updated from PubMed 12 Oct 2026
Study type 0 clinical trials · 5 preclinical · 4 unclassified
Themes one subject
Those 9 are all about one subject.
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Mitochondrial Function and Disease
Mitochondrial function is examined across cancer, fibrosis, neurodegeneration, vascular calcification and fungal virulence. Complex I inhibition is explored both as a therapeutic strategy in lung cancer and as a context-dependent intervention in arterial calcification. Other studies emphasize restoring oxidative phosphorylation, including burdock seed aglycone in renal fibrosis and OXPHOS modulation in endocrine-resistant breast cancer. The shared focus is mitochondrial stress, metabolism and signaling, without a single broader direction across these applications.
Papers
The 9 papers from the last 6 months that study Mitochondrial respiratory chain complex I directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Mitochondrial Function and Disease (9)
- Inhibition of mitochondrial complex I by rotenone reduces arterial calcification in vitro. Biochemical and biophysical research communications · 30 Jul 2026 PMID 42531909
- Integrative Multi-Omics Analysis Reveals a Mitochondrial-Immune Axis Associated With Neoadjuvant Chemotherapy Response in High-Grade Serous Ovarian Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 20 Jul 2026 PMID 42474029
- Multi-omics analysis of arginine metabolism in ovarian cancer: A prognostic signature and GTF2F2-driven stromal remodeling. Translational oncology · 13 Jul 2026 PMID 42442222
- A β-carboline natural product induces oxidative stress in Fusarium graminearum and limits the virulence of multiple fungal phytopathogens. mBio · 10 Jul 2026 PMID 42429620
- Multi-omics reveals that burdock seed aglycone alleviates renal fibrosis by restoring mitochondrial oxidative phosphorylation function. Journal of proteomics · 11 Jun 2026 PMID 42276167
- Design, synthesis, and mechanistic study of novel isoflavone derivatives as mitochondrial complex I inhibitors for non-small cell lung cancer treatment. Bioorganic chemistry · 30 May 2026 PMID 42217500
- ICAM2 promotes endocrine resistance via dynein-mediated OXPHOS activation in ER-positive breast cancer. Cell death & disease · 18 May 2026 PMID 42151122
- Simple, Fast, and Highly Efficient One- or Two-Step Proteomic Preparation Enables Deep Profiling of Microgram-Level FF and FFPE Tissues. Analytical chemistry · 28 Apr 2026 PMID 42046375
- Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline. Signal transduction and targeted therapy · 19 Apr 2026 PMID 42002550
By study type
Preclinical: animal, cell and lab studies (5)
- Inhibition of mitochondrial complex I by rotenone reduces arterial calcification in vitro. Biochemical and biophysical research communications · 30 Jul 2026 PMID 42531909
- A β-carboline natural product induces oxidative stress in Fusarium graminearum and limits the virulence of multiple fungal phytopathogens. mBio · 10 Jul 2026 PMID 42429620
- Design, synthesis, and mechanistic study of novel isoflavone derivatives as mitochondrial complex I inhibitors for non-small cell lung cancer treatment. Bioorganic chemistry · 30 May 2026 PMID 42217500
- Simple, Fast, and Highly Efficient One- or Two-Step Proteomic Preparation Enables Deep Profiling of Microgram-Level FF and FFPE Tissues. Analytical chemistry · 28 Apr 2026 PMID 42046375
- Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline. Signal transduction and targeted therapy · 19 Apr 2026 PMID 42002550
Unclassified: not yet indexed with MeSH (4)
- Integrative Multi-Omics Analysis Reveals a Mitochondrial-Immune Axis Associated With Neoadjuvant Chemotherapy Response in High-Grade Serous Ovarian Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 20 Jul 2026 PMID 42474029
- Multi-omics analysis of arginine metabolism in ovarian cancer: A prognostic signature and GTF2F2-driven stromal remodeling. Translational oncology · 13 Jul 2026 PMID 42442222
- Multi-omics reveals that burdock seed aglycone alleviates renal fibrosis by restoring mitochondrial oxidative phosphorylation function. Journal of proteomics · 11 Jun 2026 PMID 42276167
- ICAM2 promotes endocrine resistance via dynein-mediated OXPHOS activation in ER-positive breast cancer. Cell death & disease · 18 May 2026 PMID 42151122
Written from 9 PubMed abstracts, each one listed by PMID above. Published: 2026-07-15. Last written: 2026-08-27 by GPT. Drafted by language models from published abstracts; not medical advice.