Microglia

Where the papers sit

10 papers from the last 6 months study microglia directly · updated from PubMed 1 Nov 2026

• Neuroinflammation and Neurorepair

  Oxidative stress and inflammatory microglial states are being targeted to limit brain injury and promote repair. Donepezil nanosystems aim to activate mitophagy, while ROS-responsive hydrogels stage immunomodulation after hemorrhage. Que-Mn nanozymes and recombinant CXCL16 address neuroinflammation in neuralgia and ischemic stroke. The recurring strategy is multimodal control of microglial phenotype, apoptosis, and redox injury across neurological disease.

  4 papers · 40%

• Microglial Activation Pathways

  Microglial activation is linked to neuropathic pain, pelvic pain, and Alzheimer’s disease through inflammatory and phagocytic mechanisms. Daphnetin acts through the Nrf2/NLRP3 inflammasome pathway, whereas sacral nerve modulation targets the spinal immune microenvironment. Transcriptomic phagocytosis signatures are being pursued as Alzheimer’s diagnostic markers. The field is moving toward mechanism-based modulation and molecular stratification, but the pain and dementia applications remain distinct.

  3 papers · 30%

• Others — Microglial Models and Injury

  Microglial identity, particle cytotoxicity, and postoperative delirium are examined through complementary cellular and human-tissue approaches. Hematopoietic stem-cell-derived microglia-like cells are being characterized in nonhuman primates, while amine-modified silica particles are assessed for toxicity. Live human brain multi-omics instead maps neuroinflammation after surgery. The studies share microglial characterization but do not establish a common therapeutic direction.

  3 papers · 30%