L-arginine

Where the papers sit

10 papers from the last 6 months study l-arginine directly · updated from PubMed 26 Sept 2026

• Nitric Oxide in Tissue Repair

  Nitric oxide–linked biomaterials are being developed to clear biofilms, temper macrophage inflammation, and repair diabetic wounds. Chitosan hydrogels and microneedle patches combine L-arginine or Zn2+/L-Arg with mupirocin, photothermal action, or carbon-dot targeting. The recurring endpoint is faster healing alongside antibacterial and immunomodulatory effects, rather than antimicrobial activity alone. A separate gut-derived arginine study extends the biology to POMC-ACTH-cortisol signaling and insomnia, leaving its connection to wound repair unresolved.

  5 papers · 50%

• Arginine in Cancer Care

  Arginine supplementation is being tested first as supportive care for treatment toxicity and fatigue, then as a targeted metabolic intervention in cancer. Vitamin C, glutamine, and β-hydroxy-β-methylbutyrate accompany arginine during carbon-ion radiotherapy or cancer-related fatigue studies, with dermatitis, oral mucositis, and treatment outcomes as key endpoints. MOF-based nanocarriers shift the emphasis toward coordinated immunometabolic and antitumor effects in triple-negative breast cancer. Whether delivery improves efficacy beyond nutritional supplementation remains open.

  3 papers · 30%

• Others — Arginine Biochemistry and Stroke Risk

  Arginine-related work here splits between biochemical control of antibody–Protein A binding and clinical prediction after ischemic stroke. One study examines how arginine alters Fc- and VH3-mediated interactions, whereas the other evaluates symmetric dimethylarginine in patients with atrial fibrillation and cardioembolic stroke. The shared thread is measurement or modulation of arginine-associated molecular interactions, not a common disease pathway. No unified therapeutic direction or clinical endpoint emerges from the pair.

  2 papers · 20%