Gallic acid
Gallic acid is a naturally occurring phenolic acid widely distributed in plants and plant-derived foods.
Gallic acid is a naturally occurring phenolic acid widely distributed in plants and plant-derived foods. Chemically, it is a trihydroxybenzoic acid and is commonly discussed in biomedical research as a bioactive phytochemical with antioxidant, anti-inflammatory, antibacterial, and formulation-relevant properties. In the recent literature provided, gallic acid is treated less as a conventional drug target and more as a functional bioactive compound or delivery cargo whose physicochemical and biological properties can be leveraged in pharmaceutical and biomaterial systems.
Its biomedical interest stems from a combination of intrinsic activity and formulation challenges. Gallic acid is repeatedly associated with redox-modulating and antimicrobial effects, but its hydrophilic nature can limit membrane permeation and localized bioavailability, as noted in skin-delivery research. As a result, recent studies have focused on encapsulation, co-delivery, and surface-functionalized delivery platforms to improve intestinal adhesion, tissue retention, sustained release, and therapeutic performance in contexts such as oral supplementation, wound healing, atopic dermatitis, food preservation, and antibacterial materials.
Where the papers sit
12 papers from the last 6 months study gallic acid directly · updated from PubMed 9 Oct 2026
Study type 0 clinical trials · 12 preclinical
Themes one subject · 1 new direction
Those 12 are all about one subject.
-
Natural Product Bioactivity
Antioxidant, antimicrobial, antiviral, anti-inflammatory and anticancer activity dominate, with gallic acid appearing in herbal profiling, formulations and disease models. The work links chemical composition to biological effects and explores delivery approaches such as dissolving microneedles and co-crystals. Evidence remains largely analytical or preclinical, spanning biochemical assays, cell models and animals rather than clinical validation. Autophagy, oxidative stress and JAK2/STAT1 signaling recur, but no single disease or mechanism unifies the cluster.
Gallic acid is introduced as a pharmaceutical co-crystal-forming component rather than solely as a bioactive compound
The berberine–gallic acid co-crystal study on bacteriostasis against aquatic pathogens assigns gallic acid a materials-engineering role as a coformer in a defined pharmaceutical crystal, where hydrogen bonding and hydrophobic interactions help stabilize the berberine–gallic acid structure. This moves gallic acid outside the set’s usual roles as a therapeutic antioxidant, anti-inflammatory agent, antimicrobial constituent, or analytical marker, making it a component for designing the physicochemical and potentially pharmacological properties of another active ingredient 42044560Apr.
Papers
The 12 papers from the last 6 months that study gallic acid directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Natural Product Bioactivity (12)
- Antitumor efficacy and safety profile of gallic acid in the murine sarcoma 180 model. Medical oncology (Northwood, London, England) · 8 Oct 2026 PMID 42848110
- Mechanistic insights into gallic acid-induced autophagy in triple negative breast cancer through network pharmacology, molecular docking, and in vitro validation. Functional & integrative genomics · 2 Oct 2026 PMID 42825943
- UV-Spectrophotometric and RP-HPLC Method Development and Validation for Simultaneous Estimation of Gallic Acid, Quercetin, Luteolin, and Apigenin in Saraca asoca Extract. Biomedical chromatography : BMC · 12 Aug 2026 PMID 42584238
- The anti-respiratory syncytial virus activity of biochemicals from Pyrola incarnata. Antiviral research · 26 Jun 2026 PMID 42362061
- Dissolving microneedles loaded with chitosan oligosaccharides and gallic acid-modified ε-poly-L-lysine for the combined antibacterial and anti-inflammatory therapy of acne vulgaris. Journal of materials chemistry. B · 26 Jun 2026 PMID 42359722
- Neuroprotective effects of gallic acid in an MPP⁺-induced SH-sy5y cell model of parkinson's disease. Molecular biology reports · 19 Jun 2026 PMID 42319576
- UPLC Multiwavelength Quantification and PLS-DA Reveal Stir-Baking Degree-Dependent Marker Dynamics in Paeoniae Radix Alba. Biomedical chromatography : BMC · 14 Jun 2026 PMID 42289366
- Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Profiling, Antioxidant, Antibacterial, and Antidiabetic Properties of Fagonia cretica L.: Insights From In Vitro and In Silico Approaches. ChemistryOpen · 21 May 2026 PMID 42168772
- Chinese authentic herbal medicine Ganhuangcao from Southwest China mitigates influenza virus infection by inhibiting the host JAK2/STAT1 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology · 20 May 2026 PMID 42160896
- Profiling metabolites of Ficus natalensis hochst. fruit by UPLC-MS/MS and evaluation of anti-inflammatory activity. Scientific reports · 13 May 2026 PMID 42129402
- Organ-Specific Phytochemical Composition and Bioactivity Profiling of Chaerophyllum aksekiense: A Multiassay Antioxidant, Enzyme Inhibition, and Correlation-Based Evaluation. ChemistryOpen · 29 Apr 2026 PMID 42051056
- Co-crystals of berberine with two natural polyphenols: synthesis, crystal structure and bacteriostasis on aquatic pathogens. Bioorganic chemistry · 27 Apr 2026 PMID 42044560
By study type
Preclinical: animal, cell and lab studies (12)
- Antitumor efficacy and safety profile of gallic acid in the murine sarcoma 180 model. Medical oncology (Northwood, London, England) · 8 Oct 2026 PMID 42848110
- Mechanistic insights into gallic acid-induced autophagy in triple negative breast cancer through network pharmacology, molecular docking, and in vitro validation. Functional & integrative genomics · 2 Oct 2026 PMID 42825943
- UV-Spectrophotometric and RP-HPLC Method Development and Validation for Simultaneous Estimation of Gallic Acid, Quercetin, Luteolin, and Apigenin in Saraca asoca Extract. Biomedical chromatography : BMC · 12 Aug 2026 PMID 42584238
- The anti-respiratory syncytial virus activity of biochemicals from Pyrola incarnata. Antiviral research · 26 Jun 2026 PMID 42362061
- Dissolving microneedles loaded with chitosan oligosaccharides and gallic acid-modified ε-poly-L-lysine for the combined antibacterial and anti-inflammatory therapy of acne vulgaris. Journal of materials chemistry. B · 26 Jun 2026 PMID 42359722
- Neuroprotective effects of gallic acid in an MPP⁺-induced SH-sy5y cell model of parkinson's disease. Molecular biology reports · 19 Jun 2026 PMID 42319576
- UPLC Multiwavelength Quantification and PLS-DA Reveal Stir-Baking Degree-Dependent Marker Dynamics in Paeoniae Radix Alba. Biomedical chromatography : BMC · 14 Jun 2026 PMID 42289366
- Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Profiling, Antioxidant, Antibacterial, and Antidiabetic Properties of Fagonia cretica L.: Insights From In Vitro and In Silico Approaches. ChemistryOpen · 21 May 2026 PMID 42168772
- Chinese authentic herbal medicine Ganhuangcao from Southwest China mitigates influenza virus infection by inhibiting the host JAK2/STAT1 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology · 20 May 2026 PMID 42160896
- Profiling metabolites of Ficus natalensis hochst. fruit by UPLC-MS/MS and evaluation of anti-inflammatory activity. Scientific reports · 13 May 2026 PMID 42129402
- Organ-Specific Phytochemical Composition and Bioactivity Profiling of Chaerophyllum aksekiense: A Multiassay Antioxidant, Enzyme Inhibition, and Correlation-Based Evaluation. ChemistryOpen · 29 Apr 2026 PMID 42051056
- Co-crystals of berberine with two natural polyphenols: synthesis, crystal structure and bacteriostasis on aquatic pathogens. Bioorganic chemistry · 27 Apr 2026 PMID 42044560
Written from 12 PubMed abstracts, each one listed by PMID above. Published: 2026-06-16. Last written: 2026-08-27 by GPT. Drafted by language models from published abstracts; not medical advice.