Chronic kidney disease
Chronic kidney disease (CKD) is a persistent disorder of kidney structure or function, typically assessed using estimated glomerular filtration rate (eGFR) and albuminuria or proteinuria.
Chronic kidney disease (CKD) is a persistent disorder of kidney structure or function, typically assessed using estimated glomerular filtration rate (eGFR) and albuminuria or proteinuria. Progressive nephron injury can reduce glomerular filtration and promote renal fibrosis, ultimately leading to kidney failure and, in advanced cases, dialysis or end-stage renal failure. CKD is closely associated with type 2 diabetes, hypertension, obesity, cardiovascular disease, heart failure, anaemia, and abnormal lipid metabolism; its clinical burden varies across KDIGO-defined eGFR and albuminuria categories.
Current research emphasizes individualized prediction of CKD development and progression using combined clinical, metabolic, inflammatory, nutritional, and exposure-related data. Recent studies have examined prediction after radical nephrectomy, immune-inflammatory markers in older adults with obesity, atherogenicity in people with diabetes, and kidney injury after ifosfamide chemotherapy in children. Sodium glucose cotransporter-2 (SGLT2) inhibitors are an important treatment-related focus in populations with diabetes, CKD, or heart failure, although prescribing gaps remain. Other investigations are characterizing podocyte damage and testing antifibrotic mechanisms, including S1PR2 and the RhoA/ROCK pathway, to better define disease trajectories and potential therapeutic targets.
Where the papers sit
10 papers from the last 6 months study chronic kidney disease directly · updated from PubMed 1 Nov 2026
Study type 0 clinical trials · 4 observational · 3 human data · 1 preclinical · 2 unclassified
Themes 3 themes
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CKD Risk Prediction
Risk assessment is moving toward combining eGFR with inflammatory and hematologic markers rather than relying on kidney function alone. Platelet-to-lymphocyte ratio and hemoglobin-albumin-lymphocyte scores recur in patient and animal studies. Regression models target CKD after nephrectomy and after childhood ifosfamide exposure. Single-cell and spatial damage scores add a trajectory-based view, but external validation and clinical utility remain open.
5 papers · 50%
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CKD Care and Comorbidity
CKD management is being framed around metabolic, nutritional and primary-care comorbidity rather than kidney measures alone. Diabetes, obesity, anemia and hypertriglyceridemia recur across eGFR and albuminuria categories. Body-composition phenotypes are being linked to anemia and metabolic abnormalities, while prescribing data expose an SGLT2i treatment gap. The direction is toward integrated risk recognition and implementation, with real-world uptake still lagging evidence.
3 papers · 30%
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Diabetic Kidney Disease Trends
Diabetic kidney disease is increasingly tracked as a changing population burden across type 1 and type 2 diabetes. Long-term estimates from China, the USA and the UK emphasize geographic differences in prevalence and disability-adjusted life years. Atherogenic index measures add a metabolic-risk perspective for type 2 diabetes-associated kidney disease. The shared priority is earlier, more stratified prevention, although these studies remain observational.
2 papers · 20%
Papers
The 10 papers from the last 6 months that study chronic kidney disease directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
CKD Risk Prediction (5)
- Association between the hemoglobin albumin lymphocyte and platelet score and chronic kidney disease: Insights from patient data and animal models. PloS one · 14 Oct 2026 PMID 42873799
- Identification and validation of a chronic kidney disease prediction model after radical nephrectomy: a multicenter cohort retrospective study. Annals of medicine · 29 Sept 2026 PMID 42808223
- Association of immune-inflammatory markers with chronic kidney disease in older adults with obesity: a large-scale cross-sectional study. Renal failure · 24 Sept 2026 PMID 42785974
- Chronic Kidney Disease in Children Within Five Years After Ifosfamide Chemotherapy for Childhood Cancer: A Dutch Pediatric Oncology Cohort Study. Cancer medicine · 31 Aug 2026 PMID 42670233
- Cell-type-specific damage scores reveal kidney and liver disease trajectories in single-cell and spatial transcriptomics. Cell genomics · 20 Aug 2026 PMID 42624116
CKD Care and Comorbidity (3)
- Comprehensive trends in Chronic Kidney Disease prevalence and comorbidities across eGFR and albuminuria categories: a 20-year analysis of NHANES data. Renal failure · 15 Sept 2026 PMID 42736589
- The SGLT2i Treatment Gap in UK Primary Care: A Cross-Sectional RWE Study of Prescribing in Clinical Practice. Diabetes, obesity & metabolism · 11 Sept 2026 PMID 42723263
- Multidimensional nutritional and body-composition phenotypes and their associations with prevalent anaemia and metabolic abnormalities in CKD: protocol for an EHR-based retrospective baseline cross-sectional study with a prospective measurement extension. BMJ open · 24 Aug 2026 PMID 42637263
Diabetic Kidney Disease Trends (2)
- Trends in type 1 and type 2 diabetic kidney disease in China, the USA, and the UK, 1990-2023. Diabetes research and clinical practice · 3 Sept 2026 PMID 42692262
- The association between atherogenic index of plasma, cumulative atherogenic index of plasma and type 2 diabetes mellitus with chronic kidney disease among older Chinese adults: Findings from the CHARLS study. PloS one · 7 Aug 2026 PMID 42566486
By study type
Observational studies and case reports (4)
- Identification and validation of a chronic kidney disease prediction model after radical nephrectomy: a multicenter cohort retrospective study. Annals of medicine · 29 Sept 2026 PMID 42808223
- Association of immune-inflammatory markers with chronic kidney disease in older adults with obesity: a large-scale cross-sectional study. Renal failure · 24 Sept 2026 PMID 42785974
- Chronic Kidney Disease in Children Within Five Years After Ifosfamide Chemotherapy for Childhood Cancer: A Dutch Pediatric Oncology Cohort Study. Cancer medicine · 31 Aug 2026 PMID 42670233
- Multidimensional nutritional and body-composition phenotypes and their associations with prevalent anaemia and metabolic abnormalities in CKD: protocol for an EHR-based retrospective baseline cross-sectional study with a prospective measurement extension. BMJ open · 24 Aug 2026 PMID 42637263
Human data, design not indexed (3)
- Comprehensive trends in Chronic Kidney Disease prevalence and comorbidities across eGFR and albuminuria categories: a 20-year analysis of NHANES data. Renal failure · 15 Sept 2026 PMID 42736589
- Trends in type 1 and type 2 diabetic kidney disease in China, the USA, and the UK, 1990-2023. Diabetes research and clinical practice · 3 Sept 2026 PMID 42692262
- The association between atherogenic index of plasma, cumulative atherogenic index of plasma and type 2 diabetes mellitus with chronic kidney disease among older Chinese adults: Findings from the CHARLS study. PloS one · 7 Aug 2026 PMID 42566486
Preclinical: animal, cell and lab studies (1)
- Association between the hemoglobin albumin lymphocyte and platelet score and chronic kidney disease: Insights from patient data and animal models. PloS one · 14 Oct 2026 PMID 42873799
Unclassified: not yet indexed with MeSH (2)
- The SGLT2i Treatment Gap in UK Primary Care: A Cross-Sectional RWE Study of Prescribing in Clinical Practice. Diabetes, obesity & metabolism · 11 Sept 2026 PMID 42723263
- Cell-type-specific damage scores reveal kidney and liver disease trajectories in single-cell and spatial transcriptomics. Cell genomics · 20 Aug 2026 PMID 42624116
Written from 10 PubMed abstracts, each one listed by PMID above. Published: 2026-10-01. Drafted by language models from published abstracts; not medical advice.