Aryl hydrocarbon receptor (AHR)
AHR (aryl hydrocarbon receptor) is a ligand-activated transcription factor best known for sensing a wide range of endogenous Metabolites and environmental compounds.
AHR (aryl hydrocarbon receptor) is a ligand-activated transcription factor best known for sensing a wide range of endogenous Metabolites and environmental compounds. In biomedical research, it is commonly studied as a regulator of immune signaling, epithelial barrier function, xenobiotic response, and metabolic adaptation. Upon activation by agonists such as indole-derived microbial Metabolites or therapeutic small molecules, AHR can influence downstream pathways including NF-κB, MAPK, NLRP3-related inflammatory signaling, and lipid metabolism.
Recent studies have highlighted AHR as a mechanistic node linking the gut microbiota, mucosal integrity, inflammatory control, and tissue repair. In the contexts provided here, AHR was investigated in intestinal disease, skin inflammation, spinal cord injury, and cancer-related metabolic remodeling, often in combination with compounds such as tapinarof, indole-3-propionic acid, indole-3-carbinol, and irinotecan-associated nanomedicine strategies. These studies collectively support AHR as a biologically important target in inflammation-associated and metabolism-associated disease processes.
Where the papers sit
8 papers from the last 6 months study Aryl hydrocarbon receptor (AHR) directly · updated from PubMed 3 Nov 2026
Study type 0 clinical trials · 7 preclinical · 1 unclassified
Themes no clear themes
Those 8 do not share a common subject.
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AHR is linked here to weight gain, lung-cancer cell death, metabolic inflammation, skin and intestinal barriers, colitis, rheumatoid arthritis, and renal fibrosis. Reported mechanisms include heme-dependent death, C-X-C motif chemokine ligand 14, indolelactic acid, microbiota–mucin sulfation, and IDO1-KYN-AhR signaling. The findings range from dietary and microbial effects to drug sensitization and biomarker discovery. They share AHR-related biology but no single disease, mechanism, or translational direction.
Papers
The 8 papers from the last 6 months that study Aryl hydrocarbon receptor (AHR) directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
No clear themes (8)
- Validation of targets linked to weight gain in C57BL/6 mice and translational aspects in humans. Proceedings of the National Academy of Sciences of the United States of America · 22 Oct 2026 PMID 42905550
- Genome-wide CRISPR screen reveals CGS-15943 induced heme-dependent cell death mediated by aryl hydrocarbon receptor in lung cancer cells. Apoptosis : an international journal on programmed cell death · 10 Aug 2026 PMID 42573653
- 5-methoxytryptamine improves hepatic inflammation and insulin resistance in a macrophage C-X-C motif chemokine ligand 14 dependent manner. Molecular biomedicine · 28 Jun 2026 PMID 42365576
- Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor. Cell reports. Medicine · 23 Jun 2026 PMID 42335903
- Food-grade TiO2 impairs intestinal mucus barrier via disrupting the gut microbiota-ILA-mucin sulfation axis: novel insights and dietary intervention strategies. Journal of nanobiotechnology · 14 Jun 2026 PMID 42289709
- Enzymatic preparation of luteolin-rich olive (Olea europaea L.) leaf extract and its inhibitory effects on colitis. Bioorganic chemistry · 13 Jun 2026 PMID 42287884
- Erzhi pill enhances methotrexate efficacy in rheumatoid arthritis bone homeostasis via activation of the IDO1-KYN-AhR pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology · 28 May 2026 PMID 42208105
- Multi-omics identification of aging-related diagnostic genes and therapeutic targets in renal fibrosis. Clinica chimica acta; international journal of clinical chemistry · 8 May 2026 PMID 42102994
By study type
Preclinical: animal, cell and lab studies (7)
- Validation of targets linked to weight gain in C57BL/6 mice and translational aspects in humans. Proceedings of the National Academy of Sciences of the United States of America · 22 Oct 2026 PMID 42905550
- Genome-wide CRISPR screen reveals CGS-15943 induced heme-dependent cell death mediated by aryl hydrocarbon receptor in lung cancer cells. Apoptosis : an international journal on programmed cell death · 10 Aug 2026 PMID 42573653
- 5-methoxytryptamine improves hepatic inflammation and insulin resistance in a macrophage C-X-C motif chemokine ligand 14 dependent manner. Molecular biomedicine · 28 Jun 2026 PMID 42365576
- Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor. Cell reports. Medicine · 23 Jun 2026 PMID 42335903
- Enzymatic preparation of luteolin-rich olive (Olea europaea L.) leaf extract and its inhibitory effects on colitis. Bioorganic chemistry · 13 Jun 2026 PMID 42287884
- Erzhi pill enhances methotrexate efficacy in rheumatoid arthritis bone homeostasis via activation of the IDO1-KYN-AhR pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology · 28 May 2026 PMID 42208105
- Multi-omics identification of aging-related diagnostic genes and therapeutic targets in renal fibrosis. Clinica chimica acta; international journal of clinical chemistry · 8 May 2026 PMID 42102994
Unclassified: not yet indexed with MeSH (1)
- Food-grade TiO2 impairs intestinal mucus barrier via disrupting the gut microbiota-ILA-mucin sulfation axis: novel insights and dietary intervention strategies. Journal of nanobiotechnology · 14 Jun 2026 PMID 42289709
Written from 8 PubMed abstracts, each one listed by PMID above. Published: 2026-06-16. Last written: 2026-07-29 by GPT. Drafted by language models from published abstracts; not medical advice.