Phenylalanine

Where the papers sit

10 papers from the last 6 months study phenylalanine directly · updated from PubMed 5 Oct 2026

• Amino Acid Targeting and Metabolism

  Amino acids are being used both as targeting ligands and as metabolic signals. Phenylalanine- and tryptophan-based hydrazones link VEGF targeting to caspase-mediated apoptosis, while a LAT1 ligand enables lysosome-targeted degradation. Multi-omics work is positioning phenylalanine metabolism as a pancreatic cancer biomarker and therapeutic entry point. Nutritional studies instead connect amino acid mixtures with insulin and GLP-1 secretion, leaving clinical integration open.

  4 papers · 40%

• Peptide Hydrogel Self-Assembly

  Peptide hydrogels are moving toward tunable materials whose assembly, mechanics and cargo release can be programmed chemically. Aromatic interactions, halogenation and residue balance repeatedly control supramolecular networks and beta-sheet formation. Phenylalanine mutations alter tripeptide amyloid hydrogelation and cytotoxicity, while pH-responsive networks add environmental control. Cu(II)-induced assembly extends this approach to triggered drug release and functional gels.

  4 papers · 40%

• Others — Nanoparticle Biosensing and Exposure

  Nanoparticles support two distinct phenylalanine-related applications: electrochemical sensing and controlled exposure assessment. AuNP-directed orientation of phenylalanine dehydrogenase is being optimized for point-of-care biosensing through structural analysis. Nanoencapsulation of aspartame metabolites instead focuses on toxicokinetics, pharmacology and glucocorticoid-related responses. The shared emphasis is nanoparticle-enabled measurement or delivery, not a single biological question.

  2 papers · 20%