Paracetamol
Paracetamol, also known as acetaminophen and abbreviated as APAP in many biomedical studies, is a widely used over-the-counter analgesic and antipyretic.
Paracetamol, also known as acetaminophen and abbreviated as APAP in many biomedical studies, is a widely used over-the-counter analgesic and antipyretic. It is commonly employed for the relief of fever and mild to moderate pain, and it is frequently studied in the context of drug safety because of its well-known potential for dose-dependent liver injury. In toxicology and hepatology research, paracetamol is one of the standard agents used to model acute liver injury, liver necrosis, oxidative stress, reactive oxygen species generation, mitochondrial damage, and downstream hepatocyte apoptosis.
At the mechanistic level, paracetamol toxicity is often linked to depletion of glutathione, disruption of mitochondrial function, inflammatory signaling, and activation of stress-response pathways such as HIF-1α, Keap1-Nrf2, NF-κB, NLRP3 inflammasome, and JAK2/STAT3 signaling. These pathways are frequently explored in experimental systems involving hepatocyte, Kupffer cell, and liver organoid models, as well as in studies of protective interventions against acute liver injury and fibrosis. Beyond toxicology, paracetamol is also used as a pharmaceutical reference compound in formulation development and analytical chemistry.
- Mechanistic Insights into Drug Release from PLGA- and PLA-Based Implants. PMID 42969695
Where the papers sit
14 papers from the last 6 months study paracetamol directly
Study type 1 clinical trial · 4 human data · 8 preclinical · 1 unclassified
Themes one subject · 1 new direction
Those 14 are all about one subject.
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Acetaminophen Applications
Acetaminophen is being studied across toxicity, metabolism, formulation, sensing, and industrial quality control. Liver organoids, spheroids, systems pharmacology, and volunteer studies refine understanding of overdose and oxidative metabolism. Nanofibers, implants, and mesoporous carriers pursue controlled delivery, while Raman, hyperspectral, and electrochemical platforms improve assay speed. The cluster has no single research trajectory beyond broad product and safety characterization.
Acetaminophen is shown to act as a modulator of probiotic gut-bacterial growth and metabolism
The subject of the study is Lactococcus lactis subsp. lactis in monoculture and in co-culture with Clostridium butyricum within synthetic gut microbiota communities 42579196Aug. Whereas the other papers treat paracetamol as an analyte, formulation component, overdose toxicant, or exposure used to model host-organ injury, this study finds that acetaminophen alters bacterial growth dynamics and metabolite production. This extends paracetamol’s role from a drug acting on or being measured in host systems to a direct modifier of microbial-community behavior.
Papers
The 14 papers from the last 6 months that study paracetamol directly, newest first, by theme and by study type. Study types come from PubMed publication types and MeSH headings.
By theme
Acetaminophen Applications (14)
- Mechanistic Insights into Drug Release from PLGA- and PLA-Based Implants. Molecular pharmaceutics · 2 Nov 2026 PMID 42969695
- Effect of Moringa Oleifera Leaf Extract on Paracetamol Induced Liver Damage in Wistar Albino Male Rats. Mymensingh medical journal : MMJ · 30 Sept 2026 PMID 42811846
- High-Throughput eSWIR Hyperspectral Imaging for Pharmaceutical Classification at Industrial Line Speeds. AAPS PharmSciTech · 23 Sept 2026 PMID 42778720
- A systems pharmacology model for paracetamol overdose and treatment. Journal of pharmacokinetics and pharmacodynamics · 22 Sept 2026 PMID 42771058
- An advanced carbon/bismuth oxide nanoparticle-based filament for multifunctional 3D-printed electrochemical sensors toward paracetamol and lead in pharmaceutical, clinical, and environmental electroanalysis. Mikrochimica acta · 14 Sept 2026 PMID 42734674
- Hand-Held Raman Spectroscopy for Paracetamol Assay in Solution for Infusion: Expanding the Capabilities of Process Analytical Technologies. The AAPS journal · 9 Sept 2026 PMID 42711472
- Systematic Investigation on Particle and Pore Size Effects of Mesoporous Silica on Molecular Mobility and Physical Stability of Overloaded Amorphous Acetaminophen. Molecular pharmaceutics · 7 Sept 2026 PMID 42704139
- Exploring the Translation of Organ-on-a-Chip Technology for Human-Relevant Diagnostic Biomarkers. Journal of proteome research · 4 Sept 2026 PMID 42695873
- Impact of acetaminophen on the growth kinetics and metabolite production of probiotic lactic acid bacteria. Biotechnology letters · 11 Aug 2026 PMID 42579196
- MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC-Derived Liver Organoids. Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Jul 2026 PMID 42504825
- Automation of 3D liver spheroid generation and acetaminophen dose-response on the MO:BOT enhances assay robustness and precision. Scientific reports · 21 Jul 2026 PMID 42481604
- Fast-dissolving cyclodextrin nanofibers loaded with acetylsalicylic acid, paracetamol and caffeine combination for the pain treatment. International journal of pharmaceutics · 21 Jul 2026 PMID 42480728
- Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers. Clinical pharmacology and therapeutics · 14 Jul 2026 PMID 42446031
- Multi-compartmental Ni-MOF@C microcapsules for enhanced electrochemical detection of paracetamol and levofloxacin. Analytica chimica acta · 13 May 2026 PMID 42128565
By study type
Clinical trials (1)
- Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers. Clinical pharmacology and therapeutics · 14 Jul 2026 PMID 42446031
Human data, design not indexed (4)
- A systems pharmacology model for paracetamol overdose and treatment. Journal of pharmacokinetics and pharmacodynamics · 22 Sept 2026 PMID 42771058
- An advanced carbon/bismuth oxide nanoparticle-based filament for multifunctional 3D-printed electrochemical sensors toward paracetamol and lead in pharmaceutical, clinical, and environmental electroanalysis. Mikrochimica acta · 14 Sept 2026 PMID 42734674
- Exploring the Translation of Organ-on-a-Chip Technology for Human-Relevant Diagnostic Biomarkers. Journal of proteome research · 4 Sept 2026 PMID 42695873
- Automation of 3D liver spheroid generation and acetaminophen dose-response on the MO:BOT enhances assay robustness and precision. Scientific reports · 21 Jul 2026 PMID 42481604
Preclinical: animal, cell and lab studies (8)
- Mechanistic Insights into Drug Release from PLGA- and PLA-Based Implants. Molecular pharmaceutics · 2 Nov 2026 PMID 42969695
- Effect of Moringa Oleifera Leaf Extract on Paracetamol Induced Liver Damage in Wistar Albino Male Rats. Mymensingh medical journal : MMJ · 30 Sept 2026 PMID 42811846
- High-Throughput eSWIR Hyperspectral Imaging for Pharmaceutical Classification at Industrial Line Speeds. AAPS PharmSciTech · 23 Sept 2026 PMID 42778720
- Hand-Held Raman Spectroscopy for Paracetamol Assay in Solution for Infusion: Expanding the Capabilities of Process Analytical Technologies. The AAPS journal · 9 Sept 2026 PMID 42711472
- Systematic Investigation on Particle and Pore Size Effects of Mesoporous Silica on Molecular Mobility and Physical Stability of Overloaded Amorphous Acetaminophen. Molecular pharmaceutics · 7 Sept 2026 PMID 42704139
- Impact of acetaminophen on the growth kinetics and metabolite production of probiotic lactic acid bacteria. Biotechnology letters · 11 Aug 2026 PMID 42579196
- Fast-dissolving cyclodextrin nanofibers loaded with acetylsalicylic acid, paracetamol and caffeine combination for the pain treatment. International journal of pharmaceutics · 21 Jul 2026 PMID 42480728
- Multi-compartmental Ni-MOF@C microcapsules for enhanced electrochemical detection of paracetamol and levofloxacin. Analytica chimica acta · 13 May 2026 PMID 42128565
Unclassified: not yet indexed with MeSH (1)
- MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC-Derived Liver Organoids. Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Jul 2026 PMID 42504825
Written from 14 PubMed abstracts, each one listed by PMID above. Published: 2026-08-13. Last written: 2026-09-25 by GPT. Drafted by language models from published abstracts; not medical advice.